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5WGG
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BU of 5wgg by Molmil
Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides
Descriptor: CALCIUM ION, CteA, IRON/SULFUR CLUSTER, ...
Authors:Grove, T.L, Himes, P, Bowers, A, Bonanno, J.B, Almo, S.C.
Deposit date:2017-07-14
Release date:2017-07-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.036 Å)
Cite:Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides.
J. Am. Chem. Soc., 139, 2017
5WHY
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BU of 5why by Molmil
Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides
Descriptor: CALCIUM ION, IRON/SULFUR CLUSTER, Radical SAM domain protein, ...
Authors:Grove, T.L, Himes, P, Bowers, A, Bonanno, J.B, Almo, S.C.
Deposit date:2017-07-18
Release date:2017-07-26
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.692 Å)
Cite:Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides.
J. Am. Chem. Soc., 139, 2017
8VPO
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BU of 8vpo by Molmil
X-Ray Crystal Structure of TigE from Paramaledivibacter caminithermalis
Descriptor: GLYCEROL, IRON/SULFUR CLUSTER, Radical SAM core domain-containing protein
Authors:Grove, T.L, Lachowicz, J.C, Zizola, C.
Deposit date:2024-01-16
Release date:2024-02-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases.
Acs Chem.Biol., 19, 2024
6XIG
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BU of 6xig by Molmil
X-ray crystal structure of MqnE from Pedobacter heparinus
Descriptor: Aminodeoxyfutalosine synthase, D(-)-TARTARIC ACID, IRON/SULFUR CLUSTER
Authors:Grove, T.L, Bonanno, J.B, Almo, S.C.
Deposit date:2020-06-19
Release date:2020-07-15
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis.
Biochemistry, 59, 2020
6XI9
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BU of 6xi9 by Molmil
X-ray crystal structure of MqnE from Pedobacter heparinus in complex with aminofutalosine and methionine
Descriptor: 9-[7-(3-carboxyphenyl)-5,6-dideoxy-beta-D-ribo-heptodialdo-1,4-furanosyl]-9H-purin-6-amine, Aminodeoxyfutalosine synthase, CHLORIDE ION, ...
Authors:Grove, T.L, Bonanno, J.B, Almo, S.C.
Deposit date:2020-06-19
Release date:2020-07-15
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis.
Biochemistry, 59, 2020
7N7I
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BU of 7n7i by Molmil
X-ray crystal structure of Viperin-like enzyme from Trichoderma virens
Descriptor: IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE, URIDINE 5'-TRIPHOSPHATE, ...
Authors:Grove, T.L, Almo, S.C, Bonanno, J.B, Lachowicz, J.C, Gizzi, A.G.
Deposit date:2021-06-10
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life.
Biochemistry, 60, 2021
7N7H
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BU of 7n7h by Molmil
X-ray crystal structure of Viperin-like enzyme from Nematostella vectensis
Descriptor: CYTIDINE-5'-TRIPHOSPHATE, IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE, ...
Authors:Grove, T.L, Almo, S.C, Bonanno, J.B, Lachowicz, J.C, Gizzi, A.G.
Deposit date:2021-06-10
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life.
Biochemistry, 60, 2021
3RF9
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BU of 3rf9 by Molmil
X-ray structure of RlmN from Escherichia coli
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, IRON/SULFUR CLUSTER, Ribosomal RNA large subunit methyltransferase N
Authors:Boal, A.K, Grove, T.L, McLaughlin, M.I, Yennawar, N, Booker, S.J, Rosenzweig, A.C.
Deposit date:2011-04-05
Release date:2011-05-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for methyl transfer by a radical SAM enzyme.
Science, 332, 2011
6P78
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BU of 6p78 by Molmil
queuine lyase from Clostridium spiroforme bound to SAM and queuine
Descriptor: 2-amino-5-({[(1S,4S,5S)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, IRON/SULFUR CLUSTER, Queuine lyase, ...
Authors:Almo, S.C, Grove, T.L.
Deposit date:2019-06-05
Release date:2019-09-18
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.726 Å)
Cite:Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens.
Proc.Natl.Acad.Sci.USA, 116, 2019
8W1Q
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BU of 8w1q by Molmil
Aerobic crystal structure of iron-bound FlcD from Pseudomonas aeruginosa
Descriptor: FE (II) ION, GLYCEROL, MAGNESIUM ION, ...
Authors:Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R.
Deposit date:2024-02-17
Release date:2024-07-31
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme.
Acs Cent.Sci., 10, 2024
9B9M
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BU of 9b9m by Molmil
Crystal structure of iron-bound FlcD from Pseudomonas aeruginosa
Descriptor: FE (II) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C
Authors:Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R.
Deposit date:2024-04-02
Release date:2024-07-31
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme.
Acs Cent.Sci., 10, 2024
9B9O
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BU of 9b9o by Molmil
Crystal structure of FlcD from Pseudomonas aeruginosa bond to iron(II) and substrate
Descriptor: (2R)-2-{[(2Z)-2-(hydroxyimino)ethyl]sulfanyl}butanedioic acid, FE (II) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C
Authors:Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R.
Deposit date:2024-04-02
Release date:2024-07-31
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme.
Acs Cent.Sci., 10, 2024
9B9N
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BU of 9b9n by Molmil
Crystal structure of FlcD from Pseudomonas aeruginosa bound to iron (II) and substrate
Descriptor: (2R)-2-{[(2Z)-2-(hydroxyimino)ethyl]sulfanyl}butanedioic acid, FE (III) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C
Authors:Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R.
Deposit date:2024-04-02
Release date:2024-07-31
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme.
Acs Cent.Sci., 10, 2024
6C8V
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BU of 6c8v by Molmil
X-ray structure of PqqE from Methylobacterium extorquens
Descriptor: Coenzyme PQQ synthesis protein E, FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER
Authors:Gizzi, A.S, Grove, T.L, Bonanno, J.B, Almo, S.C.
Deposit date:2018-01-25
Release date:2018-02-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE.
Biochemistry, 57, 2018
3RFA
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BU of 3rfa by Molmil
X-ray structure of RlmN from Escherichia coli in complex with S-adenosylmethionine
Descriptor: IRON/SULFUR CLUSTER, Ribosomal RNA large subunit methyltransferase N, S-ADENOSYLMETHIONINE
Authors:Boal, A.K, Grove, T.L, McLaughlin, M.I, Yennawar, N, Booker, S.J, Rosenzweig, A.C.
Deposit date:2011-04-05
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for methyl transfer by a radical SAM enzyme.
Science, 332, 2011
8VCW
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BU of 8vcw by Molmil
X-Ray Crystal Structure of the biotin synthase from B. obeum
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, Biotin synthase, ...
Authors:Lachowicz, J.C, Grove, T.L.
Deposit date:2023-12-14
Release date:2024-01-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Discovery of a Biotin Synthase That Utilizes an Auxiliary 4Fe-5S Cluster for Sulfur Insertion.
J.Am.Chem.Soc., 146, 2024
8VDW
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BU of 8vdw by Molmil
X-Ray Crystal Structure of the biotin synthase from V. parvula
Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, Biotin synthase, Fe4 H S5, ...
Authors:Lachowicz, J.C, Grove, T.L.
Deposit date:2023-12-18
Release date:2024-01-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.807 Å)
Cite:Discovery of a Biotin Synthase That Utilizes an Auxiliary 4Fe-5S Cluster for Sulfur Insertion.
J.Am.Chem.Soc., 146, 2024
4ZK6
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BU of 4zk6 by Molmil
Crystallographic Capture of Quinolinate Synthase (NadA) from Pyrococcus horikoshii in its Substrates and Product-Bound States
Descriptor: ACETATE ION, CHLORIDE ION, IRON/SULFUR CLUSTER, ...
Authors:Esakova, O.A, Grove, T.L, Saunders, A.H, Yennawar, N.H, Booker, S.J.
Deposit date:2015-04-29
Release date:2016-06-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid.
J.Am.Chem.Soc., 138, 2016
5HR6
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BU of 5hr6 by Molmil
X-ray crystal structure of C118A RlmN with cross-linked tRNA purified from Escherichia coli
Descriptor: 5'-DEOXYADENOSINE, IRON/SULFUR CLUSTER, MAGNESIUM ION, ...
Authors:Schwalm, E.L, Grove, T.L, Booker, S.J, Boal, A.K.
Deposit date:2016-01-22
Release date:2016-04-13
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA.
Science, 352, 2016
5HR7
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BU of 5hr7 by Molmil
X-ray crystal structure of C118A RlmN from Escherichia coli with cross-linked in vitro transcribed tRNA
Descriptor: 5'-DEOXYADENOSINE, Dual-specificity RNA methyltransferase RlmN, IRON/SULFUR CLUSTER, ...
Authors:Schwalm, E.L, Grove, T.L, Booker, S.J, Boal, A.K.
Deposit date:2016-01-22
Release date:2016-04-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA.
Science, 352, 2016
3EPM
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BU of 3epm by Molmil
Crystal structure of Caulobacter crescentus ThiC
Descriptor: 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE, SULFATE ION, Thiamine biosynthesis protein thiC, ...
Authors:Li, S, Chatterjee, A, Zhang, Y, Grove, T.L, Lee, M, Krebs, C, Booker, S.J, Begley, T.P, Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-10-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.793 Å)
Cite:Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
Nat.Chem.Biol., 4, 2008
3EPO
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BU of 3epo by Molmil
Crystal structure of Caulobacter crescentus ThiC complexed with HMP-P
Descriptor: (4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL DIHYDROGEN PHOSPHATE, Thiamine biosynthesis protein thiC
Authors:Li, S, Chatterjee, A, Zhang, Y, Grove, T.L, Lee, M, Krebs, C, Booker, S.J, Begley, T.P, Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-10-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
Nat.Chem.Biol., 4, 2008
3EPN
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BU of 3epn by Molmil
Crystal structure of Caulobacter crescentus ThiC complexed with imidazole ribonucleotide
Descriptor: 1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole, Thiamine biosynthesis protein thiC
Authors:Li, S, Chatterjee, A, Zhang, Y, Grove, T.L, Lee, M, Krebs, C, Booker, S.J, Begley, T.P, Ealick, S.E.
Deposit date:2008-09-29
Release date:2008-10-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
Nat.Chem.Biol., 4, 2008
7MJV
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BU of 7mjv by Molmil
MiaB in the complex with s-adenosylmethionine and RNA
Descriptor: FE3-S4 CLUSTER, IRON/SULFUR CLUSTER, MAGNESIUM ION, ...
Authors:Esakova, O.A, Grove, T.L, Yennawar, N.H, Arcinas, A.J, Wang, B, Krebs, C, Almo, S.C, Booker, S.J.
Deposit date:2021-04-20
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB.
Nature, 597, 2021
7MJY
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BU of 7mjy by Molmil
MiaB in the complex with s-adenosyl-L-homocysteine and RNA
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, FE3-S4 CLUSTER, ...
Authors:Esakova, O.A, Grove, T.L, Yennawar, N.H, Arcinas, A.J, Wang, B, Krebs, C, Almo, S.C, Booker, S.J.
Deposit date:2021-04-20
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB.
Nature, 597, 2021

 

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