Author results

6H15
  • Download 6h15
  • View 6h15
Molmil generated image of 6h15
STRUCTURE OF LRP6 P3E3P4E4 IN COMPLEX WITH VHH L-P2-B10
Descriptor:Low-density lipoprotein receptor-related protein 6, VHH L-P2-B10, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gros, P., van Scherpenzeel, R.C.
Deposit date:2018-07-11
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Nat Commun, 10, 2019
6H16
  • Download 6h16
  • View 6h16
Molmil generated image of 6h16
STRUCTURE OF LRP6 P3E3P4E4 IN COMPLEX WITH VHH L-P2-D07
Descriptor:Low-density lipoprotein receptor-related protein 6, VHH L-P2-D07, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gros, P., van Scherpenzeel, R.C.
Deposit date:2018-07-11
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Nat Commun, 10, 2019
6CPM
  • Download 6cpm
  • View 6cpm
Molmil generated image of 6cpm
STRUCTURE OF THE USP15 DEUBIQUITINASE DOMAIN IN COMPLEX WITH A THIRD-GENERATION INHIBITORY UBV
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.1d, CALCIUM ION, ...
Authors:Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
Deposit date:2018-03-13
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6CRN
  • Download 6crn
  • View 6crn
Molmil generated image of 6crn
STRUCTURE OF THE USP15 DEUBIQUITINASE DOMAIN IN COMPLEX WITH A HIGH-AFFINITY FIRST-GENERATION UBV
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.2, ZINC ION
Authors:Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
Deposit date:2018-03-19
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6DJ9
  • Download 6dj9
  • View 6dj9
Molmil generated image of 6dj9
STRUCTURE OF THE USP15 DUSP DOMAIN IN COMPLEX WITH A HIGH-AFFINITY UBIQUITIN VARIANT (UBV)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin Variant UbV 15.D
Authors:Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
Deposit date:2018-05-24
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6ML1
  • Download 6ml1
  • View 6ml1
Molmil generated image of 6ml1
STRUCTURE OF THE USP15 DEUBIQUITINASE DOMAIN IN COMPLEX WITH AN AFFINITY-MATURED INHIBITORY UBV
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15,Ubiquitin carboxyl-terminal hydrolase 15,Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.1a, Proteolyzed N-terminal tag of Ubv.15.1a construct, ...
Authors:Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
Deposit date:2018-09-26
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6HCY
  • Download 6hcy
  • View 6hcy
Molmil generated image of 6hcy
HUMAN STEAP4 BOUND TO NADP, FAD, HEME AND FE(III)-NTA.
Descriptor:Metalloreductase STEAP4, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Oosterheert, W., van Bezouwen, L.S., Rodenburg, R.N.P., Forster, F., Mattevi, A., Gros, P.
Deposit date:2018-08-17
Release date:2018-10-24
Last modified:2018-10-31
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.
Nat Commun, 9, 2018
6HD1
  • Download 6hd1
  • View 6hd1
Molmil generated image of 6hd1
HUMAN STEAP4 BOUND TO NADPH, FAD AND HEME.
Descriptor:Metalloreductase STEAP4, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Oosterheert, W., van Bezouwen, L.S., Rodenburg, R.N.P., Forster, F., Mattevi, A., Gros, P.
Deposit date:2018-08-17
Release date:2018-10-24
Last modified:2018-10-31
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.
Nat Commun, 9, 2018
5O4G
  • Download 5o4g
  • View 5o4g
Molmil generated image of 5o4g
HER2 IN COMPLEX WITH FAB MF3958
Descriptor:Receptor tyrosine-protein kinase erbB-2, MF3958 FAB light chain, MF3958 FAB heavy chain, ...
Authors:De Nardis, C., Gros, P.
Deposit date:2017-05-29
Release date:2018-05-16
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
5O4O
  • Download 5o4o
  • View 5o4o
Molmil generated image of 5o4o
HER3 IN COMPLEX WITH FAB MF3178
Descriptor:MF3178 FAB light chain, MF3178 FAB heavy chain, Receptor tyrosine-protein kinase erbB-3, ...
Authors:De Nardis, C., Gros, P.
Deposit date:2017-05-30
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
5O7P
  • Download 5o7p
  • View 5o7p
Molmil generated image of 5o7p
HER3 IN COMPLEX WITH FAB MF3178
Descriptor:Receptor tyrosine-protein kinase erbB-3, MF3178 FAB light chain, MF3178 FAB heavy chain, ...
Authors:De Nardis, C., Gros, P.
Deposit date:2017-06-09
Release date:2018-05-16
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
6FCZ
  • Download 6fcz
  • View 6fcz
Molmil generated image of 6fcz
MODEL OF GC1Q-FC COMPLEX BASED ON 7A EM MAP
Descriptor:Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, ...
Authors:Ugurlar, D., Howes, S.C., de Kreuk, B.J.K., de Jong, R.N., Beurskens, F.J., Koster, A.J., Parren, P.W.H.I., Sharp, T.H., Gros, P., Koning, R.I.
Deposit date:2017-12-21
Release date:2018-02-28
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.
Science, 359, 2018
5NSC
  • Download 5nsc
  • View 5nsc
Molmil generated image of 5nsc
FC DEKK HETERODIMER VARIANT
Descriptor:Putative uncharacterized protein DKFZp686C11235, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:De Nardis, C., Hendriks, L.J.A., Poirier, E., Arvinte, T., Gros, P., Bakker, A.B.H., de Kruif, J.
Deposit date:2017-04-26
Release date:2017-07-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.
J. Biol. Chem., 292, 2017
5NSG
  • Download 5nsg
  • View 5nsg
Molmil generated image of 5nsg
FC DEDE HOMODIMER VARIANT
Descriptor:Putative uncharacterized protein DKFZp686C11235, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:De Nardis, C., Hendriks, L.J.A., Poirier, E., Arvinte, T., Gros, P., Bakker, A.B.H., de Kruif, J.
Deposit date:2017-04-26
Release date:2017-07-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.
J. Biol. Chem., 292, 2017
5O32
  • Download 5o32
  • View 5o32
Molmil generated image of 5o32
THE STRUCTURE OF COMPLEMENT COMPLEX
Descriptor:Complement C3, Complement factor H,Complement factor H, Complement factor I, ...
Authors:Xue, X., Wu, J., Forneris, F., Gros, P.
Deposit date:2017-05-23
Release date:2017-06-28
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (4.206209 Å)
Cite:Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
5O35
  • Download 5o35
  • View 5o35
Molmil generated image of 5o35
STRUCTURE OF COMPLEMENT PROTEINS COMPLEX
Descriptor:Complement C3, Complement factor H,Complement factor H, N-ACETYL-D-GLUCOSAMINE
Authors:Xue, X., Wu, J., Forneris, F., Gros, P.
Deposit date:2017-05-23
Release date:2017-06-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
5FO7
  • Download 5fo7
  • View 5fo7
Molmil generated image of 5fo7
CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B AT 2.8 ANGSTROM RESOLUTION
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, N-ACETYL-D-GLUCOSAMINE
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO8
  • Download 5fo8
  • View 5fo8
Molmil generated image of 5fo8
CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH MCP (CCP1-4)
Descriptor:COMPLEMENT C3, MEMBRANE COFACTOR PROTEIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO9
  • Download 5fo9
  • View 5fo9
Molmil generated image of 5fo9
CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH CR1 (CCP15- 17)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT RECEPTOR TYPE 1, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FOA
  • Download 5foa
  • View 5foa
Molmil generated image of 5foa
CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH DAF (CCP2-4)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (4.188 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FOB
  • Download 5fob
  • View 5fob
Molmil generated image of 5fob
CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH SMALLPOX INHIBITOR OF COMPLEMENT (SPICE)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, SMALLPOX INHIBITOR OF COMPLEMENT SPICE, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
4CDJ
  • Download 4cdj
  • View 4cdj
Molmil generated image of 4cdj
STRUCTURE OF ZNRF3 ECTODOMAIN
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE ZNRF3, 1,2-ETHANEDIOL, FORMIC ACID
Authors:Peng, W.C., de Lau, W., Madoori, P.K., Forneris, F., Granneman, J.C.M., Clevers, H., Gros, P.
Deposit date:2013-11-01
Release date:2014-01-08
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structures of Wnt-Antagonist Znrf3 and its Complex with R-Spondin 1 and Implications for Signaling.
Plos One, 8, 2013
4CDK
  • Download 4cdk
  • View 4cdk
Molmil generated image of 4cdk
STRUCTURE OF ZNRF3-RSPO1
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE ZNRF3, R-SPONDIN-1
Authors:Peng, W.C., de Lau, W., Madoori, P.K., Forneris, F., Granneman, J.C.M., Clevers, H., Gros, P.
Deposit date:2013-11-01
Release date:2014-01-08
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Wnt-Antagonist Znrf3 and its Complex with R-Spondin 1 and Implications for Signaling.
Plos One, 8, 2013
4CBN
  • Download 4cbn
  • View 4cbn
Molmil generated image of 4cbn
CRYSTAL STRUCTURE OF COMPLEMENT FACTOR D MUTANT R202A AFTER CONVENTIONAL REFINEMENT
Descriptor:COMPLEMENT FACTOR D, GLYCEROL
Authors:Forneris, F., Burnley, B.T., Gros, P.
Deposit date:2013-10-15
Release date:2013-12-18
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ensemble Refinement Shows Conformational Flexibility in Crystal Structures of Human Complement Factor D
Acta Crystallogr.,Sect.D, 70, 2014
4CBO
  • Download 4cbo
  • View 4cbo
Molmil generated image of 4cbo
CRYSTAL STRUCTURE OF COMPLEMENT FACTOR D MUTANT R202A AFTER ENSEMBLE REFINEMENT
Descriptor:COMPLEMENT FACTOR D, GLYCEROL
Authors:Forneris, F., Burnley, B.T., Gros, P.
Deposit date:2013-10-15
Release date:2013-12-18
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ensemble Refinement Shows Conformational Flexibility in Crystal Structures of Human Complement Factor D
Acta Crystallogr.,Sect.D, 70, 2014