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6S0B
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CRYSTAL STRUCTURE OF PROPERDIN IN COMPLEX WITH THE CTC DOMAIN OF C3/C3B
Descriptor:Properdin, Complement C3, ALPHA-D-MANNOSE, ...
Authors:van den Bos, R.M., Pearce, N.M., Gros, P.
Deposit date:2019-06-14
Release date:2019-09-04
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.312 Å)
Cite:Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
Front Immunol, 10, 2019
6S0A
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CRYSTAL STRUCTURE OF PROPERDIN (TSR DOMAINS N12 & 456)
Descriptor:Properdin, ALPHA-D-MANNOSE, ALPHA-L-FUCOSE, ...
Authors:van den Bos, R.M., Pearce, N.M., Gros, P.
Deposit date:2019-06-14
Release date:2019-09-04
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
Front Immunol, 10, 2019
6S08
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CRYSTAL STRUCTURE OF PROPERDIN (TSR DOMAINS N1 & 456)
Descriptor:Properdin, ALPHA-D-MANNOSE, TRIETHYLENE GLYCOL, ...
Authors:van den Bos, R.M., Pearce, N.M., Gros, P.
Deposit date:2019-06-14
Release date:2019-09-04
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b.
Front Immunol, 10, 2019
6ML1
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STRUCTURE OF THE USP15 DEUBIQUITINASE DOMAIN IN COMPLEX WITH AN AFFINITY-MATURED INHIBITORY UBV
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15,Ubiquitin carboxyl-terminal hydrolase 15,Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.1a, Proteolyzed N-terminal tag of Ubv.15.1a construct, ...
Authors:Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
Deposit date:2018-09-26
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6HD1
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HUMAN STEAP4 BOUND TO NADPH, FAD AND HEME.
Descriptor:Metalloreductase STEAP4, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Oosterheert, W., van Bezouwen, L.S., Rodenburg, R.N.P., Forster, F., Mattevi, A., Gros, P.
Deposit date:2018-08-17
Release date:2018-10-24
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.
Nat Commun, 9, 2018
6HCY
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HUMAN STEAP4 BOUND TO NADP, FAD, HEME AND FE(III)-NTA.
Descriptor:Metalloreductase STEAP4, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Oosterheert, W., van Bezouwen, L.S., Rodenburg, R.N.P., Forster, F., Mattevi, A., Gros, P.
Deposit date:2018-08-17
Release date:2018-10-24
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction.
Nat Commun, 9, 2018
6H16
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STRUCTURE OF LRP6 P3E3P4E4 IN COMPLEX WITH VHH L-P2-D07
Descriptor:Low-density lipoprotein receptor-related protein 6, VHH L-P2-D07, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gros, P., van Scherpenzeel, R.C.
Deposit date:2018-07-11
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Nat Commun, 10, 2019
6H15
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STRUCTURE OF LRP6 P3E3P4E4 IN COMPLEX WITH VHH L-P2-B10
Descriptor:Low-density lipoprotein receptor-related protein 6, VHH L-P2-B10, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Gros, P., van Scherpenzeel, R.C.
Deposit date:2018-07-11
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.
Nat Commun, 10, 2019
6FCZ
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MODEL OF GC1Q-FC COMPLEX BASED ON 7A EM MAP
Descriptor:Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, ...
Authors:Ugurlar, D., Howes, S.C., de Kreuk, B.J.K., de Jong, R.N., Beurskens, F.J., Koster, A.J., Parren, P.W.H.I., Sharp, T.H., Gros, P., Koning, R.I.
Deposit date:2017-12-21
Release date:2018-02-28
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.
Science, 359, 2018
6DJ9
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STRUCTURE OF THE USP15 DUSP DOMAIN IN COMPLEX WITH A HIGH-AFFINITY UBIQUITIN VARIANT (UBV)
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin Variant UbV 15.D
Authors:Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
Deposit date:2018-05-24
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6CRN
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STRUCTURE OF THE USP15 DEUBIQUITINASE DOMAIN IN COMPLEX WITH A HIGH-AFFINITY FIRST-GENERATION UBV
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.2, ZINC ION
Authors:Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
Deposit date:2018-03-19
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
6CPM
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STRUCTURE OF THE USP15 DEUBIQUITINASE DOMAIN IN COMPLEX WITH A THIRD-GENERATION INHIBITORY UBV
Descriptor:Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.1d, CALCIUM ION, ...
Authors:Singer, A.U., Teyra, J., Boehmelt, G., Lenter, M., Sicheri, F., Sidhu, S.S.
Deposit date:2018-03-13
Release date:2019-01-23
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
5O7P
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HER3 IN COMPLEX WITH FAB MF3178
Descriptor:Receptor tyrosine-protein kinase erbB-3, MF3178 FAB light chain, MF3178 FAB heavy chain, ...
Authors:De Nardis, C., Gros, P.
Deposit date:2017-06-09
Release date:2018-05-16
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
5O4O
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HER3 IN COMPLEX WITH FAB MF3178
Descriptor:MF3178 FAB light chain, MF3178 FAB heavy chain, Receptor tyrosine-protein kinase erbB-3, ...
Authors:De Nardis, C., Gros, P.
Deposit date:2017-05-30
Release date:2018-05-16
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
5O4G
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HER2 IN COMPLEX WITH FAB MF3958
Descriptor:Receptor tyrosine-protein kinase erbB-2, MF3958 FAB light chain, MF3958 FAB heavy chain, ...
Authors:De Nardis, C., Gros, P.
Deposit date:2017-05-29
Release date:2018-05-16
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.
Cancer Cell, 33, 2018
5O35
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STRUCTURE OF COMPLEMENT PROTEINS COMPLEX
Descriptor:Complement C3, Complement factor H,Complement factor H, N-ACETYL-D-GLUCOSAMINE
Authors:Xue, X., Wu, J., Forneris, F., Gros, P.
Deposit date:2017-05-23
Release date:2017-06-28
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
5O32
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THE STRUCTURE OF COMPLEMENT COMPLEX
Descriptor:Complement C3, Complement factor H,Complement factor H, Complement factor I, ...
Authors:Xue, X., Wu, J., Forneris, F., Gros, P.
Deposit date:2017-05-23
Release date:2017-06-28
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (4.206209 Å)
Cite:Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017
5NSG
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FC DEDE HOMODIMER VARIANT
Descriptor:Putative uncharacterized protein DKFZp686C11235, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:De Nardis, C., Hendriks, L.J.A., Poirier, E., Arvinte, T., Gros, P., Bakker, A.B.H., de Kruif, J.
Deposit date:2017-04-26
Release date:2017-07-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.
J. Biol. Chem., 292, 2017
5NSC
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FC DEKK HETERODIMER VARIANT
Descriptor:Putative uncharacterized protein DKFZp686C11235, Fc-III peptide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:De Nardis, C., Hendriks, L.J.A., Poirier, E., Arvinte, T., Gros, P., Bakker, A.B.H., de Kruif, J.
Deposit date:2017-04-26
Release date:2017-07-05
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.
J. Biol. Chem., 292, 2017
5FOB
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH SMALLPOX INHIBITOR OF COMPLEMENT (SPICE)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, SMALLPOX INHIBITOR OF COMPLEMENT SPICE, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FOA
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH DAF (CCP2-4)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (4.188 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO9
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH CR1 (CCP15- 17)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT RECEPTOR TYPE 1, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO8
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH MCP (CCP1-4)
Descriptor:COMPLEMENT C3, MEMBRANE COFACTOR PROTEIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO7
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B AT 2.8 ANGSTROM RESOLUTION
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, N-ACETYL-D-GLUCOSAMINE
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
4CDK
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STRUCTURE OF ZNRF3-RSPO1
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE ZNRF3, R-SPONDIN-1
Authors:Peng, W.C., de Lau, W., Madoori, P.K., Forneris, F., Granneman, J.C.M., Clevers, H., Gros, P.
Deposit date:2013-11-01
Release date:2014-01-08
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Wnt-Antagonist Znrf3 and its Complex with R-Spondin 1 and Implications for Signaling.
Plos One, 8, 2013