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1QA4
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BU of 1qa4 by Molmil
HIV-1 NEF ANCHOR DOMAIN, NMR, 2 STRUCTURES
Descriptor: Protein Nef
Authors:Geyer, M, Kalbitzer, H.R.
Deposit date:1999-04-12
Release date:1999-05-26
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein.
J.Mol.Biol., 289, 1999
2RGF
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BU of 2rgf by Molmil
RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES
Descriptor: RALGEF-RBD
Authors:Geyer, M, Herrmann, C, Wittinghofer, A, Kalbitzer, H.R.
Deposit date:1997-02-13
Release date:1998-03-04
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling.
Nat.Struct.Biol., 4, 1997
1QA5
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BU of 1qa5 by Molmil
MYRISTOYLATED HIV-1 NEF ANCHOR DOMAIN, NMR, 2 STRUCTURES
Descriptor: PROTEIN (MYRISTOYLATED HIV-1 NEF ANCHOR DOMAIN (MYRISTATE-GLY2 TO TRP57))
Authors:Geyer, M, Kalbitzer, H.R.
Deposit date:1999-04-12
Release date:1999-05-26
Last modified:2022-12-21
Method:SOLUTION NMR
Cite:Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein.
J.Mol.Biol., 289, 1999
4ORZ
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BU of 4orz by Molmil
HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain
Descriptor: Protein Nef, Tyrosine-protein kinase HCK, single domain antibody sdAb19
Authors:Geyer, M, Lulf, S.
Deposit date:2014-02-12
Release date:2014-03-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody.
Retrovirology, 11, 2014
1ZTN
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BU of 1ztn by Molmil
INACTIVATION GATE OF POTASSIUM CHANNEL RAW3, NMR, 8 STRUCTURES
Descriptor: Potassium voltage-gated channel subfamily C member 4
Authors:Antz, C, Geyer, M, Fakler, B, Schott, M, Frank, R, Guy, H.R, Ruppersberg, J.P, Kalbitzer, H.R.
Deposit date:1996-11-15
Release date:1997-06-05
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:NMR structure of inactivation gates from mammalian voltage-dependent potassium channels.
Nature, 385, 1997
7NXJ
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BU of 7nxj by Molmil
Crystal structure of human Cdk13/Cyclin K in complex with the inhibitor THZ531
Descriptor: Cyclin-K, Cyclin-dependent kinase 13, N-[4-[(3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidin-1-yl]carbonylphenyl]-4-(dimethylamino)butanamide
Authors:Anand, K, Greifenberg, A.K, Kaltheuner, I.H, Geyer, M.
Deposit date:2021-03-18
Release date:2021-05-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.
Eur.J.Med.Chem., 221, 2021
7NXK
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BU of 7nxk by Molmil
Crystal structure of human Cdk12/Cyclin K in complex with the inhibitor BSJ-01-175
Descriptor: (E)-N-[4-[(1R,3R)-3-[[5-chloranyl-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide, Cyclin-K, Cyclin-dependent kinase 12
Authors:Anand, K, Dust, S, Kaltheuner, I.H, Geyer, M.
Deposit date:2021-03-18
Release date:2021-05-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma.
Eur.J.Med.Chem., 221, 2021
3DAD
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BU of 3dad by Molmil
Crystal structure of the N-terminal regulatory domains of the formin FHOD1
Descriptor: FH1/FH2 domain-containing protein 1
Authors:Schulte, A, Stolp, B, Schonichen, A, Pylypenko, O, Rak, A, Fackler, O.T, Geyer, M.
Deposit date:2008-05-29
Release date:2008-09-16
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Human Formin FHOD1 Contains a Bipartite Structure of FH3 and GTPase-Binding Domains Required for Activation.
Structure, 16, 2008
3RBB
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BU of 3rbb by Molmil
HIV-1 NEF protein in complex with engineered HCK SH3 domain
Descriptor: 1,2-ETHANEDIOL, Protein Nef, Tyrosine-protein kinase HCK
Authors:Horenkamp, F.A, Schulte, A, Weyand, M, Geyer, M.
Deposit date:2011-03-29
Release date:2011-04-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly.
Traffic, 12, 2011
8P81
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BU of 8p81 by Molmil
Crystal structure of human Cdk12/Cyclin K in complex with inhibitor SR-4835
Descriptor: Cyclin-K, Cyclin-dependent kinase 12, ~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine
Authors:Anand, K, Schmitz, M, Geyer, M.
Deposit date:2023-05-31
Release date:2023-11-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation.
J.Biol.Chem., 300, 2023
8PYR
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BU of 8pyr by Molmil
Crystal structure of the dual T-loop phosphorylated Cdk7/CycH/Mat1 complex
Descriptor: 1,2-ETHANEDIOL, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
Authors:Anand, K, Duster, R, Geyer, M.
Deposit date:2023-07-26
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis of Cdk7 activation by dual T-loop phosphorylation.
Biorxiv, 2024
2L1A
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BU of 2l1a by Molmil
Solution NMR structure of the N-terminal GTPase-like domain of dictyostelium discoideum Fomin C
Descriptor: Formin-C
Authors:Dames, S.A, Schoenichen, A, Stephan, G, Geyer, M.
Deposit date:2010-07-27
Release date:2011-08-17
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structure, dynamics, lipid binding, and physiological relevance of the putative GTPase-binding domain of Dictyostelium formin C.
J.Biol.Chem., 286, 2011
3REA
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BU of 3rea by Molmil
HIV-1 Nef protein in complex with engineered Hck-SH3 domain
Descriptor: Protein Nef, Tyrosine-protein kinase HCK
Authors:Schulte, A, Blankenfeldt, W, Geyer, M.
Deposit date:2011-04-04
Release date:2011-06-01
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
PLoS ONE, 6, 2011
3S9G
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BU of 3s9g by Molmil
Structure of human Hexim1 (delta stammer) coiled coil domain
Descriptor: Protein HEXIM1
Authors:Bigalke, J.M, Blankenfeldt, W, Geyer, M.
Deposit date:2011-06-01
Release date:2011-10-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and Dynamics of a Stabilized Coiled-Coil Domain in the P-TEFb Regulator Hexim1.
J.Mol.Biol., 414, 2011
7PZC
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BU of 7pzc by Molmil
Cryo-EM structure of the NLRP3 decamer bound to the inhibitor CRID3
Descriptor: 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ...
Authors:Hochheiser, I.V, Pilsl, M, Hagelueken, G, Engel, C, Geyer, M.
Deposit date:2021-10-12
Release date:2022-01-26
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.
Nature, 604, 2022
5EFQ
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BU of 5efq by Molmil
Crystal structure of human Cdk13/Cyclin K in complex with ADP-aluminum fluoride
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Cyclin-K, ...
Authors:Hoenig, D, Greifenberg, A.K, Anand, K, Geyer, M.
Deposit date:2015-10-24
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Functional Analysis of the Cdk13/Cyclin K Complex.
Cell Rep, 14, 2016
8CMU
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BU of 8cmu by Molmil
High resolution structure of the coagulation Factor XIII A2B2 heterotetramer complex.
Descriptor: Coagulation factor XIII A chain, Coagulation factor XIII B chain
Authors:Singh, S, Urgular, D, Hagelueken, G, Geyer, M, Biswas, A.
Deposit date:2023-02-21
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (2.41 Å)
Cite:The cryo-EM structure of the plasma coagulation Factor XIII complex at 2.68 Angstrom resolution.
To Be Published
8CMT
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BU of 8cmt by Molmil
Structure of the plasma coagulation Factor XIII A2B2 heterotetrameric complex.
Descriptor: Coagulation factor XIII A chain, Coagulation factor XIII B chain
Authors:Singh, S, Ugurlar, D, Hagelueken, G, Geyer, M, Biswas, A.
Deposit date:2023-02-21
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:The cryo-EM structure of plasma coagulation Factor XIII heterotetrameric complex at 2.68 Angstrom resolution.
To Be Published
3BW6
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BU of 3bw6 by Molmil
Crystal structure of the longin domain of yeast Ykt6
Descriptor: SULFATE ION, Synaptobrevin homolog YKT6
Authors:Pylypenko, O, Schonichen, A, Ludwig, D, Ungermann, C, Goody, R.S, Rak, A, Geyer, M.
Deposit date:2008-01-08
Release date:2008-04-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding.
J.Mol.Biol., 377, 2008
7BAI
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BU of 7bai by Molmil
Structure of RIG-I CTD (I875A) bound to p-RNA
Descriptor: Antiviral innate immune response receptor RIG-I, RNA (5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3'), ZINC ION
Authors:Anand, K, Hagelueken, G, Fusshoeller, D, Geyer, M.
Deposit date:2020-12-15
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:A conserved isoleucine in the RNA sensor RIG-I controls immune tolerance to mitochondrial RNA
To Be Published
7BAH
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BU of 7bah by Molmil
Structure of RIG-I CTD bound to OH-RNA
Descriptor: Antiviral innate immune response receptor RIG-I, RNA (5'-R(*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3'), ZINC ION
Authors:Anand, K, Hagelueken, G, Fusshoeller, D, Geyer, M.
Deposit date:2020-12-15
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:A conserved isoleucine in the RNA sensor RIG-I controls immune tolerance to mitochondrial RNA
To Be Published
4NST
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BU of 4nst by Molmil
Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ...
Authors:Boesken, C.A, Farnung, L, Anand, K, Geyer, M.
Deposit date:2013-11-29
Release date:2014-03-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure and substrate specificity of human Cdk12/Cyclin K.
Nat Commun, 5, 2014
1ZTO
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BU of 1zto by Molmil
INACTIVATION GATE OF POTASSIUM CHANNEL RCK4, NMR, 8 STRUCTURES
Descriptor: POTASSIUM CHANNEL PROTEIN RCK4
Authors:Antz, C, Geyer, M, Fakler, B, Schott, M, Frank, R, Guy, H.R, Ruppersberg, J.P, Kalbitzer, H.R.
Deposit date:1996-11-15
Release date:1997-06-05
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:NMR structure of inactivation gates from mammalian voltage-dependent potassium channels.
Nature, 385, 1997
7PZD
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BU of 7pzd by Molmil
Cryo-EM structure of the NLRP3 PYD filament
Descriptor: NACHT, LRR and PYD domains-containing protein 3
Authors:Hochheiser, I.V, Hagelueken, G, Behrmann, H, Behrmann, E, Geyer, M.
Deposit date:2021-10-12
Release date:2022-04-20
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation.
Sci Adv, 8, 2022
7O7K
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BU of 7o7k by Molmil
Crystal structure of the human DYRK1A kinase domain bound to abemaciclib
Descriptor: 1,2-ETHANEDIOL, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ...
Authors:Kaltheuner, I.H, Anand, K, Geyer, M.
Deposit date:2021-04-13
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.
Nat Commun, 12, 2021

 

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