2RGF
RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES
Summary for 2RGF
| Entry DOI | 10.2210/pdb2rgf/pdb |
| Descriptor | RALGEF-RBD (1 entity in total) |
| Functional Keywords | ras-binding domain, ralgef, ralgds, ras, rbd |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 11136.64 |
| Authors | Geyer, M.,Herrmann, C.,Wittinghofer, A.,Kalbitzer, H.R. (deposition date: 1997-02-13, release date: 1998-03-04, Last modification date: 2024-05-22) |
| Primary citation | Geyer, M.,Herrmann, C.,Wohlgemuth, S.,Wittinghofer, A.,Kalbitzer, H.R. Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling. Nat.Struct.Biol., 4:694-699, 1997 Cited by PubMed Abstract: The solution structure of the Ras-binding domain (RBD) of Ral guanine-nucleotide exchange factor RalGEF was solved by NMR spectroscopy. The overall structure is similar to that of Raf-RBD, another effector of Ras, although the sequence identity is only 13%. 15N chemical shifts changes in the complex of RalGEF-RBD with Ras indicate an interaction similar to the intermolecular beta-sheet observed for the complex between Ras and Raf-RBD. PubMed: 9302994DOI: 10.1038/nsb0997-694 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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