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2OY0
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CRYSTAL STRUCTURE OF THE WEST NILE VIRUS METHYLTRANSFERASE
Descriptor:Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, H.M., Zhao, Y.W., Guo, Y., Shi, P.Y.
Deposit date:2007-02-21
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and Function of Flavivirus NS5 Methyltransferase.
J.Virol., 81, 2007
3E3R
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CRYSTAL STRUCTURE AND BIOCHEMICAL CHARACTERIZATION OF RECOMBINANT HUMAN CALCYPHOSINE DELINEATES A NOVEL EF-HAND-CONTAINING PROTEIN FAMILY
Descriptor:Calcyphosin, CALCIUM ION
Authors:Dong, H.
Deposit date:2008-08-07
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family
J.Mol.Biol., 383, 2008
3LKZ
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STRUCTURAL AND FUNCTIONAL ANALYSES OF A CONSERVED HYDROPHOBIC POCKET OF FLAVIVIRUS METHYLTRANSFERASE
Descriptor:Non-structural protein 5, SINEFUNGIN, GLYCEROL
Authors:Liu, L.H., Li, H.M.
Deposit date:2010-01-28
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase.
J.Biol.Chem., 285, 2010
2L0J
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SOLID STATE NMR STRUCTURE OF THE M2 PROTON CHANNEL FROM INFLUENZA A VIRUS IN HYDRATED LIPID BILAYER
Descriptor:Matrix protein 2
Authors:Sharma, M., Yi, M., Dong, H., Qin, H., Peterson, E., Busath, D.D., Zhou, H.X., Cross, T.A.
Deposit date:2010-07-08
Release date:2010-11-03
Last modified:2011-07-13
Method:SOLID-STATE NMR
Cite:Insight into the mechanism of the influenza a proton channel from a structure in a lipid bilayer.
Science, 330, 2010
3MWP
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NUCLEOPROTEIN STRUCTURE OF LASSA FEVER VIRUS
Descriptor:Nucleoprotein, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.795 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
3MWT
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CRYSTAL STRUCTURE OF LASSA FEVER VIRUS NUCLEOPROTEIN IN COMPLEX WITH MN2+
Descriptor:Nucleoprotein, MANGANESE (II) ION, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (1.982 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
3MX2
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LASSA FEVER VIRUS NUCLEOPROTEIN COMPLEXED WITH DTTP
Descriptor:Nucleoprotein, THYMIDINE-5'-TRIPHOSPHATE, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (1.983 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
3MX5
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LASSA FEVER VIRUS NUCLEOPROTEIN COMPLEXED WITH UTP
Descriptor:Nucleoprotein, URIDINE 5'-TRIPHOSPHATE, ZINC ION
Authors:Qi, X., Lan, S., Wang, W., Schelde, L.M., Dong, H., Wallat, G., Liang, Y., Ly, H., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2010-05-06
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
3P8Z
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DENGUE METHYLTRANSFERASE BOUND TO A SAM-BASED INHIBITOR
Descriptor:Non-structural protein 5, (S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Noble, C.G., Yap, L.J., Lescar, J.
Deposit date:2010-10-15
Release date:2010-12-08
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
3P97
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO THE SUBSTRATE S-ADENOSYL METHIONINE
Descriptor:Non-structural protein 5, S-ADENOSYLMETHIONINE
Authors:Noble, C.G., Yap, L.J., Lescar, J.
Deposit date:2010-10-16
Release date:2010-12-08
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
3N6L
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THE CRYSTAL STRUCUTRE OF RNA-DEPENDENT RNA POLYMERASE OF EV71 VIRUS
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION
Authors:Wu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3N6M
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CRYSTAL STRUCTURE OF EV71 RDRP IN COMPLEX WITH GTP
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Wu, Y., Lou, Z.Y., Miao, Y., Yu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3N6N
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CRYSTAL STRUCTURE OF EV71 RDRP IN COMPLEX WITH BR-UTP
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION, 5-bromouridine 5'-(tetrahydrogen triphosphate)
Authors:Wu, Y., Lou, Z.Y., Miao, Y., Yu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3Q6S
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THE CRYSTAL STRUCTURE OF THE HETEROCHROMATIN PROTEIN 1 BETA CHROMOSHADOW DOMAIN COMPLEXED WITH A PEPTIDE FROM SHUGOSHIN 1
Descriptor:Chromobox protein homolog 1, Shugoshin-like 1
Authors:Brautigam, C.A., Chaudhary, J., Yu, H.
Deposit date:2011-01-03
Release date:2011-12-14
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.
Mol Biol Cell, 22, 2011
4G9Z
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LASSA NUCLEOPROTEIN WITH DSRNA REVEALS NOVEL MECHANISM FOR IMMUNE SUPPRESSION
Descriptor:RNA (5'-R(P*GP*CP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*C)-3'), Nucleoprotein, ...
Authors:Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C., Scottish Structural Proteomics Facility (SSPF)
Deposit date:2012-07-24
Release date:2013-04-03
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
4IDU
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CRYSTAL STRUCTURE OF SCHMALLENBERG VIRUS NUCLEOPROTEIN
Descriptor:SBV nucleoprotein
Authors:Dong, H., Li, P., Elliott, R.M., Dong, C.
Deposit date:2012-12-13
Release date:2013-04-24
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Structure of Schmallenberg orthobunyavirus nucleoprotein suggests a novel mechanism of genome encapsidation
J.Virol., 87, 2013
4IDX
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HEXAMERIC CRYSTAL STRUCTURE OF SCHMALLENBERG VIRUS NUCLEOPROTEIN
Descriptor:Nucleocapsid protein
Authors:Dong, H., Dong, C.
Deposit date:2012-12-13
Release date:2013-04-24
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Structure of Schmallenberg orthobunyavirus nucleoprotein suggests a novel mechanism of genome encapsidation
J.Virol., 87, 2013
4GV3
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STRUCTURES OF LASSA AND TACARIBE VIRAL NUCLEOPROTEINS WITH OR WITHOUT 5 TRIPHOSPHATE DSRNA SUBSTRATE REVEAL A UNIQUE 3 -5 EXORIBONUCLEASE MECHANISM TO SUPPRESS TYPE I INTERFERON PRODUCTION
Descriptor:RNA (5'-R(*(GTP)P*GP*GP*C)-3'), RNA (5'-R(P*CP*GP*CP*CP*C)-3'), Nucleoprotein, ...
Authors:Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
4GV6
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STRUCTURES OF LASSA AND TACARIBE VIRAL NUCLEOPROTEINS WITH OR WITHOUT 5 TRIPHOSPHATE DSRNA SUBSTRATE REVEAL A UNIQUE 3 -5 EXORIBONUCLEASE MECHANISM TO SUPPRESS TYPE I INTERFERON PRODUCTION
Descriptor:RNA (5'-R(*(GTP)P*GP*GP*C)-3'), RNA (5'-R(P*CP*GP*CP*CP*C)-3'), Nucleoprotein, ...
Authors:Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
4GV9
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LASSA NUCLEOPROTEIN C-TERMINAL DOMAIN IN COMPLEX WITH TRIPHOSPHATED DSRNA SOAKING FOR 5 MIN
Descriptor:RNA (5'-R(*(GTP)P*GP*GP*C)-3'), RNA (5'-R(P*CP*GP*CP*CP*C)-3'), Nucleoprotein, ...
Authors:Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
4GVE
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TACARIBE NUCLEOPROTEIN STRUCTURE
Descriptor:Nucleoprotein, ZINC ION, MAGNESIUM ION
Authors:Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
Deposit date:2012-08-30
Release date:2013-05-01
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression.
J.Biol.Chem., 288, 2013
4L3P
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CRYSTAL STRUCTURE OF 2-(1-BENZOTHIOPHEN-7-YL)-4-[1-(PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL]FURO[2,3-C]PYRIDIN-7-AMINE BOUND TO TAK1-TAB1
Descriptor:Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera, 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine
Authors:Wang, J., Hornberger, K.R., Crew, A.P., Steinbacher, S., Maskos, K., Moertl, M.
Deposit date:2013-06-06
Release date:2013-06-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
Bioorg.Med.Chem.Lett., 23, 2013
4L52
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CRYSTAL STRUCTURE OF 1-(4-{4-[7-AMINO-2-(1,2,3-BENZOTHIADIAZOL-7-YL)FURO[2,3-C]PYRIDIN-4-YL]-1H-PYRAZOL-1-YL}PIPERIDIN-1-YL)ETHAN-1-ONE BOUND TO TAK1-TAB1
Descriptor:Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera, 1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]-1H-pyrazol-1-yl}piperidin-1-yl)ethanone
Authors:Wang, J., Hornberger, K.R., Crew, A.P., Jestel, A., Maskos, K., Moertl, M.
Deposit date:2013-06-10
Release date:2013-07-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
Bioorg.Med.Chem.Lett., 23, 2013
4MIW
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HIGH-RESOLUTION STRUCTURE OF THE N-TERMINAL ENDONUCLEASE DOMAIN OF THE LASSA VIRUS L POLYMERASE
Descriptor:RNA-directed RNA polymerase L, MAGNESIUM ION
Authors:Wallat, G.D., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y., Dong, C.
Deposit date:2013-09-02
Release date:2014-03-19
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:High-resolution structure of the N-terminal endonuclease domain of the lassa virus L polymerase in complex with magnesium ions.
Plos One, 9, 2014
4KNB
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C-MET IN COMPLEX WITH OSI LIGAND
Descriptor:Hepatocyte growth factor receptor, 7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine, GAMMA-BUTYROLACTONE
Authors:Wang, J., Steinig, A.G., Li, A.H., Chen, X., Dong, H., Ferraro, C., Jin, M., Kadalbajoo, M., Kleinberg, A., Stolz, K.M., Tavares-Greco, P.A., Wang, T., Albertella, M.R., Peng, Y., Crew, L., Kahler, J.
Deposit date:2013-05-09
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.
Bioorg.Med.Chem.Lett., 23, 2013
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