Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2RCR
DownloadVisualize
BU of 2rcr by Molmil
STRUCTURE OF THE MEMBRANE-BOUND PROTEIN PHOTOSYNTHETIC REACTION CENTER FROM RHODOBACTER SPHAEROIDES
Descriptor: BACTERIOCHLOROPHYLL A, BACTERIOPHEOPHYTIN A, Coenzyme Q10, ...
Authors:Chang, C.-H, Norris, J, Schiffer, M.
Deposit date:1991-02-04
Release date:1993-07-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the membrane-bound protein photosynthetic reaction center from Rhodobacter sphaeroides.
Biochemistry, 30, 1991
2D2W
DownloadVisualize
BU of 2d2w by Molmil
Solution structure and Dynamics of the DNA-Binding Domain of Myocyte Nuclear Factor
Descriptor: Forkhead box protein K1
Authors:Chuang, W.-J, Chang, C.-H, Jeng, W.-Y, Chu, Y.-P.
Deposit date:2005-09-19
Release date:2006-09-05
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution Structure and Backbone Dynamics of the DNA-Binding Domain of Myocyte Nuclear Factor (Foxk1)
TO BE PUBLISHED
1HVR
DownloadVisualize
BU of 1hvr by Molmil
RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
Descriptor: HIV-1 PROTEASE, [4R-(4ALPHA,5ALPHA,6BETA,7BETA)]-HEXAHYDRO-5,6-DIHYDROXY-1,3-BIS[2-NAPHTHYL-METHYL]-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPIN-2-ONE
Authors:Chang, C.-H.
Deposit date:1994-02-14
Release date:1995-01-26
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors.
Science, 263, 1994
2P93
DownloadVisualize
BU of 2p93 by Molmil
Factor xa in complex with the inhibitor 5-chloro-N-(2-(4-(2-oxopyridin-1(2H)-yl)benzamido)ethyl)thiophene-2-carboxamide
Descriptor: 5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE, Factor Xa
Authors:Chang, C.-H.
Deposit date:2007-03-23
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa
Bioorg.Med.Chem.Lett., 17, 2007
2P94
DownloadVisualize
BU of 2p94 by Molmil
Factor xa in complex with the inhibitor 3-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)benzamido)cyclohexyl)-1H-indole-6-carboxamide
Descriptor: 3-CHLORO-N-((1R,2S) -2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)CYCLOHEXYL)-1H-INDOLE-6-CARBOXAMIDE, Factor Xa
Authors:Chang, C.-H.
Deposit date:2007-03-23
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa
Bioorg.Med.Chem.Lett., 17, 2007
2P95
DownloadVisualize
BU of 2p95 by Molmil
Factor xa in complex with the inhibitor 5-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-YL)benzamido) cyclopentyl)thiophene-2-carboxamide
Descriptor: 5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE, Factor Xa
Authors:Chang, C.-H.
Deposit date:2007-03-23
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa
Bioorg.Med.Chem.Lett., 17, 2007
3CEN
DownloadVisualize
BU of 3cen by Molmil
Factor XA in complex with the inhibitor N-(2-(((5-chloro-2-pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2H)-pyridinyl)benzamide
Descriptor: COAGULATION FACTOR X, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Chang, C.-H.
Deposit date:2008-02-29
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Activity Relationships of Anthranilamide-Based Factor Xa Inhibitors Containing Piperidinone and Pyridinone P4 Moieties
Bioorg.Med.Chem.Lett., 18, 2008
2A3S
DownloadVisualize
BU of 2a3s by Molmil
Solution structure and Dynamics of DNA-Binding Domain of Myocyte Nuclear Factor
Descriptor: Myocyte Nuclear Factor
Authors:Chuang, W.-J, Chang, C.-H, Jeng, W.-Y, Chu, Y.-P.
Deposit date:2005-06-27
Release date:2006-06-13
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure and Dynamics of DNA-Binding Domain of Myocyte Nuclear Factor
to be published
1LVE
DownloadVisualize
BU of 1lve by Molmil
STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K-4 LIGHT CHAIN LEN
Descriptor: LEN, A VARIABLE DOMAIN FROM KAPPA-4 TYPE
Authors:Schiffer, M, Huang, D.-B, Chang, C.-H.
Deposit date:1996-07-17
Release date:1998-01-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Variable domain structure of kappaIV human light chain Len: high homology to the murine light chain McPC603.
Mol.Immunol., 34, 1997
2C6Y
DownloadVisualize
BU of 2c6y by Molmil
Crystal structure of interleukin enhancer-binding factor 1 bound to DNA
Descriptor: FORKHEAD BOX PROTEIN K2, INTERLEUKIN 2 PROMOTOR, MAGNESIUM ION
Authors:Tsai, K.-L, Huang, C.-Y, Chang, C.-H, Sun, Y.-J, Chuang, W.-J, Hsiao, C.-D.
Deposit date:2005-11-15
Release date:2006-04-18
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Human Foxk1A-DNA Complex and its Implications on the Diverse Binding Specificity of Winged Helix/Forkhead Proteins.
J.Biol.Chem., 281, 2006
1DMP
DownloadVisualize
BU of 1dmp by Molmil
STRUCTURE OF HIV-1 PROTEASE COMPLEX
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS([(3-AMINO)PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPINONE
Authors:Chang, C.-H.
Deposit date:1996-11-01
Release date:1997-11-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450.
Chem.Biol., 3, 1996
1HWR
DownloadVisualize
BU of 1hwr by Molmil
MOLECULAR RECOGNITION OF CYCLIC UREA HIV PROTEASE INHIBITORS
Descriptor: HIV-1 PROTEASE, [4-R-(4-ALPHA,6-BETA,7-BETA]-HEXAHYDRO-5,6-DI(HYDROXY)-1,3-DI(ALLYL)-4,7-BISPHENYLMETHYL)-2H-1,3-DIAZEPINONE
Authors:Chang, C.-H.
Deposit date:1998-03-20
Release date:1999-03-23
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular recognition of cyclic urea HIV-1 protease inhibitors.
J.Biol.Chem., 273, 1998
1HVH
DownloadVisualize
BU of 1hvh by Molmil
NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV PROTEASE INHIBITORS
Descriptor: HIV-1 PROTEASE, {[4-R(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS(4-HYDROXYMETHYL)METHYL]-4,7-BIS(PHENYLMETHYL) -2H-1,3-DIAZEPIN-2-YLIDENE]CYANAMIDE}
Authors:Chang, C.-H.
Deposit date:1997-12-13
Release date:1998-12-30
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.
J.Med.Chem., 41, 1998
1QBU
DownloadVisualize
BU of 1qbu by Molmil
HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
Descriptor: HIV-1 PROTEASE, [4R--(1ALPHA,5ALPHA,7BETA)]-3-[(CYCLOPROPHYLMETHYL)HEXAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPIN] METHYL-2-THIAZOLYLBENZAMIDE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-25
Release date:1997-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.
J.Med.Chem., 40, 1997
1QBS
DownloadVisualize
BU of 1qbs by Molmil
HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)]-2H-1,3-DIAZEPINONE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-25
Release date:1997-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.
J.Med.Chem., 39, 1996
3MRU
DownloadVisualize
BU of 3mru by Molmil
Crystal Structure of Aminoacylhistidine Dipeptidase from Vibrio alginolyticus
Descriptor: Aminoacyl-histidine dipeptidase, ZINC ION
Authors:Chang, C.-Y, Hsieh, Y.-C, Wu, T.-K, Chen, C.-J.
Deposit date:2010-04-29
Release date:2010-09-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure and mutational analysis of aminoacylhistidine dipeptidase from vibrio alginolyticus reveal a new architecture of M20 metallopeptidases
J.Biol.Chem., 285, 2010
5LVE
DownloadVisualize
BU of 5lve by Molmil
STRUCTURE OF THE VARIABLE DOMAIN OF HUMAN IMMUNOGLOBULIN K-4 LIGHT CHAIN LEN
Descriptor: BENCE-JONES PROTEIN LEN, ZINC ION
Authors:Schiffer, M, Huang, D.-B, Chang, C.-H.
Deposit date:1999-02-24
Release date:2000-02-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Change in dimerization mode by removal of a single unsatisfied polar residue located at the interface.
Protein Sci., 9, 2000
3GIV
DownloadVisualize
BU of 3giv by Molmil
Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance
Descriptor: Beta-2-microglobulin, HIV-1 peptide, HLA class I histocompatibility antigen, ...
Authors:Stewart-Jones, G, Iversen, A.K.N, Jones, E.Y.
Deposit date:2009-03-06
Release date:2009-06-30
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance
Nat.Immunol., 10, 2009
4BJL
DownloadVisualize
BU of 4bjl by Molmil
LOCW, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN DISTILLED WATER
Descriptor: LOC - LAMBDA 1 TYPE LIGHT-CHAIN DIMER
Authors:Schiffer, M, Huang, D.B.
Deposit date:1995-05-26
Release date:1995-12-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Three quaternary structures for a single protein.
Proc.Natl.Acad.Sci.USA, 93, 1996
1BJM
DownloadVisualize
BU of 1bjm by Molmil
LOC NAKS, A LAMBDA 1 TYPE LIGHT-CHAIN DIMER (BENCE-JONES PROTEIN) CRYSTALLIZED IN NAKSO4
Descriptor: LOC - LAMBDA 1 TYPE LIGHT-CHAIN DIMER
Authors:Schiffer, M, Huang, D.B.
Deposit date:1995-05-26
Release date:1995-12-07
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three quaternary structures for a single protein.
Proc.Natl.Acad.Sci.USA, 93, 1996
1MET
DownloadVisualize
BU of 1met by Molmil
HIV-1 MUTANT (V82F) PROTEASE COMPLEXED WITH DMP323
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-11
Release date:1998-04-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.
Biochemistry, 36, 1997
1MEU
DownloadVisualize
BU of 1meu by Molmil
HIV-1 MUTANT (V82F, I84V) PROTEASE COMPLEXED WITH DMP323
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-11
Release date:1998-04-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.
Biochemistry, 36, 1997
1MER
DownloadVisualize
BU of 1mer by Molmil
HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP450
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS([(3-AMINO)PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPINONE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-11
Release date:1998-04-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.
Biochemistry, 36, 1997
1MES
DownloadVisualize
BU of 1mes by Molmil
HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP323
Descriptor: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-11
Release date:1998-04-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.
Biochemistry, 36, 1997
1QBT
DownloadVisualize
BU of 1qbt by Molmil
HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
Descriptor: HIV-1 PROTEASE, [4R-(4ALPHA,5ALPHA,6ALPHA,7ALPHA)]-3,3'-{{TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-DIYL]BIS(METHYLENE)]BIS[N-1H-BENZIMIDAZOL-2-YLBENZAMIDE]
Authors:Ala, P, Chang, C.-H.
Deposit date:1997-04-25
Release date:1997-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.
J.Med.Chem., 40, 1997

 

12>

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon