1HWR

MOLECULAR RECOGNITION OF CYCLIC UREA HIV PROTEASE INHIBITORS

Summary for 1HWR

• Entry DOI: 10.2210/pdb1hwr/pdb
• Descriptor: HIV-1 PROTEASE, [4-R-(4-ALPHA,6-BETA,7-BETA]-HEXAHYDRO-5,6-DI(HYDROXY)-1,3-DI(ALLYL)-4,7-BISPHENYLMETHYL)-2H-1,3-DIAZEPINONE (2 entities in total)
• Functional Keywords: aspartyl protease, hydrolase, acid proteinase
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• Total number of polymer chains: 2
• Total formula weight: 21921.85

Authors

Chang, C.-H. (deposition date: 1998-03-20, release date: 1999-03-23, Last modification date: 2023-08-09)

• Primary citation: Ala, P.J.,DeLoskey, R.J.,Huston, E.E.,Jadhav, P.K.,Lam, P.Y.,Eyermann, C.J.,Hodge, C.N.,Schadt, M.C.,Lewandowski, F.A.,Weber, P.C.,McCabe, D.D.,Duke, J.L.,Chang, C.H.; Molecular recognition of cyclic urea HIV-1 protease inhibitors.; J.Biol.Chem., 273:12325-12331, 1998; PubMed: 9575185; DOI: 10.1074/jbc.273.20.12325

Experimental method

X-RAY DIFFRACTION (1.8 Å)