1HWR

MOLECULAR RECOGNITION OF CYCLIC UREA HIV PROTEASE INHIBITORS

Summary for 1HWR
DescriptorHIV-1 PROTEASE, [4-R-(4-ALPHA,6-BETA,7-BETA]-HEXAHYDRO-5,6-DI(HYDROXY)-1,3-DI(ALLYL)-4,7-BISPHENYLMETHYL)-2H-1,3-DIAZEPINONE (2 entities in total)
Functional Keywordsaspartyl protease, hydrolase, acid proteinase
Biological sourceHuman immunodeficiency virus 1
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
Total number of polymer chains2
Total formula weight21921.85
Authors
Chang, C.-H. (deposition date: 1998-03-20, release date: 1999-03-23, Last modification date: 2017-11-29)
Primary citationAla, P.J.,Chang, C.H.,DeLoskey, R.J.,Duke, J.L.,Eyermann, C.J.,Hodge, C.N.,Huston, E.E.,Jadhav, P.K.,Lam, P.Y.,Lewandowski, F.A.,McCabe, D.D.,Schadt, M.C.,Weber, P.C.
Molecular recognition of cyclic urea HIV-1 protease inhibitors.
J.Biol.Chem., 273:12325-12331, 1998
PubMed: 9575185
DOI: 110.1074/jbc.273.20.12325
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation
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PDB entries from 2021-06-16