1QBT
HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
Summary for 1QBT
Entry DOI | 10.2210/pdb1qbt/pdb |
Descriptor | HIV-1 PROTEASE, [4R-(4ALPHA,5ALPHA,6ALPHA,7ALPHA)]-3,3'-{{TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-DIYL]BIS(METHYLENE)]BIS[N-1H-BENZIMIDAZOL-2-YLBENZAMIDE] (2 entities in total) |
Functional Keywords | hydrolase (acid proteinase), aspartyl protease |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 |
Total number of polymer chains | 2 |
Total formula weight | 22340.25 |
Authors | Ala, P.,Chang, C.-H. (deposition date: 1997-04-25, release date: 1997-10-15, Last modification date: 2024-02-14) |
Primary citation | Jadhav, P.K.,Ala, P.,Woerner, F.J.,Chang, C.H.,Garber, S.S.,Anton, E.D.,Bacheler, L.T. Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV. J.Med.Chem., 40:181-191, 1997 Cited by PubMed: 9003516DOI: 10.1021/jm960586t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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