2P94

Factor xa in complex with the inhibitor 3-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-yl)benzamido)cyclohexyl)-1H-indole-6-carboxamide

Summary for 2P94
Related2P93 2P95
DescriptorFactor Xa, 3-CHLORO-N-((1R,2S) -2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)CYCLOHEXYL)-1H-INDOLE-6-CARBOXAMIDE, ... (4 entities in total)
Functional Keywordsglycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P00742 P00742
Total number of polymer chains2
Total formula weight32525.30
Authors
Chang, C.-H. (deposition date: 2007-03-23, release date: 2007-07-24, Last modification date: 2011-07-13)
Primary citationChang, C.-H.,Cheney, D.L.,King, S.R.,Knabb, R.M.,Lam, P.Y.S.,Luettgen, J.M.,Morin, P.E.,Qiao, J.X.,Rendina, A.R.,Wang, G.Z.,Wang, T.C.,Wexler, R.R.
SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa
Bioorg.Med.Chem.Lett., 17:4419-4427, 2007
PubMed: 17588746
DOI: 110.1016/j.bmcl.2007.06.029
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation
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PDB entries from 2021-06-16