2P95

Factor xa in complex with the inhibitor 5-chloro-N-((1R,2S)-2-(4-(2-oxopyridin-1(2H)-YL)benzamido) cyclopentyl)thiophene-2-carboxamide

Summary for 2P95

• Entry DOI: 10.2210/pdb2p95/pdb
• Related: 2P93 2P94
• Descriptor: Factor Xa, 5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE, ... (4 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32478.27

Authors

Chang, C.-H. (deposition date: 2007-03-23, release date: 2007-07-24, Last modification date: 2017-10-18)

• Primary citation: Qiao, J.X.,Chang, C.-H.,Cheney, D.L.,Morin, P.E.,Wang, G.Z.,King, S.R.,Wang, T.C.,Rendina, A.R.,Luettgen, J.M.,Knabb, R.M.,Wexler, R.R.,Lam, P.Y.S.; SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa; Bioorg.Med.Chem.Lett., 17:4419-4427, 2007; PubMed: 17588746; DOI: 10.1016/j.bmcl.2007.06.029

Experimental method

X-RAY DIFFRACTION (2.2 Å)