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2P93

Factor xa in complex with the inhibitor 5-chloro-N-(2-(4-(2-oxopyridin-1(2H)-yl)benzamido)ethyl)thiophene-2-carboxamide

Summary for 2P93
Entry DOI10.2210/pdb2p93/pdb
Related2P94 2P95
DescriptorFactor Xa, 5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE, ... (4 entities in total)
Functional Keywordsglycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P00742 P00742
Total number of polymer chains2
Total formula weight32438.20
Authors
Chang, C.-H. (deposition date: 2007-03-23, release date: 2007-07-24, Last modification date: 2017-10-18)
Primary citationQiao, J.X.,Chang, C.-H.,Cheney, D.L.,Morin, P.E.,Wang, G.Z.,King, S.R.,Wang, T.C.,Rendina, A.R.,Luettgen, J.M.,Knabb, R.M.,Wexler, R.R.,Lam, P.Y.S.
SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa
Bioorg.Med.Chem.Lett., 17:4419-4427, 2007
Cited by
PubMed: 17588746
DOI: 10.1016/j.bmcl.2007.06.029
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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