3CEN

Factor XA in complex with the inhibitor N-(2-(((5-chloro-2-pyridinyl) amino)sulfonyl)phenyl)-4-(2-oxo-1(2H)-pyridinyl)benzamide

Summary for 3CEN

• Entry DOI: 10.2210/pdb3cen/pdb
• Descriptor: COAGULATION FACTOR X, HEAVY CHAIN, COAGULATION FACTOR X, LIGHT CHAIN, N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE, ... (4 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, hydroxylation, polymorphism, zymogen
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32517.26

Authors

Chang, C.-H. (deposition date: 2008-02-29, release date: 2008-05-20, Last modification date: 2024-10-30)

Primary citation

Corte, J.R.,Fang, T.,Pinto, D.J.P.,Han, W.,Hu, Z.,Jiang, X.-J.,Li, Y.-L.,Gauuan, J.F.,Hadden, M.,Orton, D.,Rendina, A.R.,Luettgen, J.M.,Wong, P.C.,He, K.,Morin, P.,Chang, C.-H.,Cheney, D.L.,Knabb, R.M.,Wexler, R.R.,Lam, P.Y.S.
Structure-Activity Relationships of Anthranilamide-Based Factor Xa Inhibitors Containing Piperidinone and Pyridinone P4 Moieties
Bioorg.Med.Chem.Lett., 18:2845-2849, 2008

PubMed Abstract: Introduction of the phenyl piperidinone and phenyl pyridinone P4 moieties in the anthranilamide scaffold led to potent, selective, and orally bioavailable inhibitors of factor Xa. Anthranilamide 28 displayed comparable efficacy to apixaban in the rabbit arteriovenous-shunt (AV) thrombosis model.

PubMed: 18424044
DOI: 10.1016/j.bmcl.2008.03.092

Experimental method

X-RAY DIFFRACTION (1.6 Å)