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1MEU

HIV-1 MUTANT (V82F, I84V) PROTEASE COMPLEXED WITH DMP323

Summary for 1MEU
Entry DOI10.2210/pdb1meu/pdb
DescriptorHIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE (2 entities in total)
Functional Keywordshydrolase, acid proteinase, aspartyl protease
Biological sourceHuman immunodeficiency virus 1
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
Total number of polymer chains2
Total formula weight22214.18
Authors
Ala, P.,Chang, C.-H. (deposition date: 1997-04-11, release date: 1998-04-15, Last modification date: 2023-08-09)
Primary citationAla, P.J.,Huston, E.E.,Klabe, R.M.,McCabe, D.D.,Duke, J.L.,Rizzo, C.J.,Korant, B.D.,DeLoskey, R.J.,Lam, P.Y.,Hodge, C.N.,Chang, C.H.
Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.
Biochemistry, 36:1573-1580, 1997
Cited by
PubMed: 9048541
DOI: 10.1021/bi962234u
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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