Author results

1PCP
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SOLUTION STRUCTURE OF A TREFOIL-MOTIF-CONTAINING CELL GROWTH FACTOR, PORCINE SPASMOLYTIC PROTEIN
Descriptor:PORCINE SPASMOLYTIC PROTEIN
Authors:Carr, M.D., Bauer, C.J., Gradwell, M.J., Feeney, J.
Deposit date:1993-02-04
Release date:1994-05-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of a trefoil-motif-containing cell growth factor, porcine spasmolytic protein.
Proc.Natl.Acad.Sci.USA, 91, 1994
1NYO
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SOLUTION STRUCTURE OF THE ANTIGENIC TB PROTEIN MPT70/MPB70
Descriptor:Immunogenic protein MPT70
Authors:Bloemink, M.J., Dentten, E., Hewinson, R.G., Williamson, R.A., Carr, M.D., TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-02-13
Release date:2003-08-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease
J.Biol.Chem., 278, 2003
2TMP
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N-TERMINAL DOMAIN OF TISSUE INHIBITOR OF METALLOPROTEINASE-2 (N-TIMP-2), NMR, 49 STRUCTURES
Descriptor:TISSUE INHIBITOR OF METALLOPROTEINASES-2
Authors:Muskett, F.W., Frenkiel, T.A., Feeney, J., Freedman, R.B., Carr, M.D., Williamson, R.A.
Deposit date:1998-05-26
Release date:1998-12-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3.
J.Biol.Chem., 273, 1998
1A5J
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CHICKEN B-MYB DNA BINDING DOMAIN, REPEAT 2 AND REPEAT3, NMR, 32 STRUCTURES
Descriptor:B-MYB
Authors:Mcintosh, P.B., Carr, M.D., Wollborn, U., Frenkiel, T.A., Feeney, J., Mccormick, J.E., Klempnauer, K.H.
Deposit date:1998-02-16
Release date:1998-07-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the B-Myb DNA-binding domain: a possible role for conformational instability of the protein in DNA binding and control of gene expression.
Biochemistry, 37, 1998
1WA8
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SOLUTION STRUCTURE OF THE CFP-10.ESAT-6 COMPLEX. MAJOR VIRULENCE DETERMINANTS OF PATHOGENIC MYCOBACTERIA
Descriptor:ESAT-6 LIKE PROTEIN ESXB, 6 KDA EARLY SECRETORY ANTIGENIC TARGET (ESAT-6)
Authors:Renshaw, P.S., Lightbody, K.L., Veverka, V., Muskett, F.W., Kelly, G., Frenkiel, T.A., Gordon, S.V., Hewinson, R.G., Burke, B., Norman, J., Williamson, R.A., Carr, M.D., TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-10-25
Release date:2005-06-27
Method:SOLUTION NMR
Cite:Structure and Function of the Complex Formed by the Tuberculosis Virulence Factors Cfp-10 and Esat-6
Embo J., 24, 2005
2HM8
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SOLUTION STRUCTURE OF THE C-TERMINAL MA-3 DOMAIN OF PDCD4
Descriptor:Pdcd4 C-terminal MA-3 domain
Authors:Waters, L.C., Veverka, V., Bohm, M., Muskett, F.W., Choong, P.T., Klempnauer, K.H., Carr, M.D.
Deposit date:2006-07-11
Release date:2007-02-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A
Oncogene, 26, 2007
2K8P
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CHARACTERISATION OF THE STRUCTURAL FEATURES AND INTERACTIONS OF SCLEROSTIN: MOLECULAR INSIGHT INTO A KEY REGULATOR OF WNT-MEDIATED BONE FORMATION
Descriptor:Sclerostin
Authors:Veverka, V., Henry, A.J., Slocombe, P.M., Ventom, A., Mulloy, B., Muskett, F.W., Muzylak, M., Greenslade, K., Moore, A., Zhang, L., Gong, J., Qian, X., Paszty, C., Taylor, R.J., Robinson, M.K., Carr, M.D.
Deposit date:2008-09-18
Release date:2009-02-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation
J.Biol.Chem., 284, 2009
2KH2
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SOLUTION STRUCTURE OF A SCFV-IL-1B COMPLEX
Descriptor:Interleukin-1 beta, scFv
Authors:Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D.
Deposit date:2009-03-23
Release date:2009-09-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development.
J.Biol.Chem., 284, 2009
2KZT
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STRUCTURE OF THE TANDEM MA-3 REGION OF PDCD4
Descriptor:Programmed cell death protein 4
Authors:Waters, L.C., Strong, S.L., Oka, O., Muskett, F.W., Veverka, V., Banerjee, S., Schmedt, T., Henry, A.J., Klempnauer, K.H., Carr, M.D.
Deposit date:2010-06-24
Release date:2011-03-16
Last modified:2011-11-23
Method:SOLUTION NMR
Cite:Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor
J.Biol.Chem., 286, 2011
2L3Y
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SOLUTION STRUCTURE OF MOUSE IL-6
Descriptor:Interleukin-6
Authors:Veverka, V., Redpath, N.T., Carrington, B., Muskett, F.W., Taylor, R.J., Henry, A.J., Carr, M.D.
Deposit date:2010-09-25
Release date:2011-09-28
Last modified:2013-01-02
Method:SOLUTION NMR
Cite:Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
2M2D
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HUMAN PROGRAMMED CELL DEATH 1 RECEPTOR
Descriptor:Programmed cell death protein 1
Authors:Veverka, V., Cheng, X., Waters, L.C., Muskett, F.W., Morgan, S., Lesley, A., Griffiths, M., Stubberfield, C., Griffin, R., Henry, A.J., Robinson, M.K., Jansson, A., Ladbury, J.E., Ikemizu, S., Davis, S.J., Carr, M.D.
Deposit date:2012-12-18
Release date:2013-02-27
Last modified:2013-05-15
Method:SOLUTION NMR
Cite:Structure and interactions of the human programmed cell death 1 receptor.
J.Biol.Chem., 288, 2013
2M4V
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MYCOBACTERIUM TUBERCULOSIS RNA POLYMERASE BINDING PROTEIN A (RBPA) AND ITS INTERACTIONS WITH SIGMA FACTORS
Descriptor:Putative uncharacterized protein
Authors:Bortoluzzi, A., Muskett, F.W., Waters, L.C., Addis, P.W., Rieck, B., Munder, T., Schleier, S., Forti, F., Ghisotti, D., Carr, M.D., O'Hare, H.M.
Deposit date:2013-02-11
Release date:2013-04-17
Last modified:2013-08-07
Method:SOLUTION NMR
Cite:Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.
J.Biol.Chem., 288, 2013
2NPU
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THE SOLUTION STRUCTURE OF THE RAPAMYCIN-BINDING DOMAIN OF MTOR (FRB)
Descriptor:FKBP12-rapamycin complex-associated protein
Authors:Veverka, V., Crabbe, T., Bird, I., Lennie, G., Muskett, F.W., Taylor, R.J., Carr, M.D.
Deposit date:2006-10-30
Release date:2007-09-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27, 2008
5O57
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SOLUTION STRUCTURE OF THE N-TERMINAL REGION OF DKK4
Descriptor:Dickkopf-related protein 4
Authors:Waters, L.C., Patel, S., Barkell, A.M., Muskett, F.W., Robinson, M.K., Holdsworth, G., Carr, M.D.
Deposit date:2017-06-01
Release date:2018-06-13
Last modified:2018-08-15
Method:SOLUTION NMR
Cite:Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
J. Biol. Chem., 293, 2018
1E9T
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HIGH RESOLUTION SOLUTION STRUCTURE OF HUMAN INTESTINAL TREFOIL FACTOR
Descriptor:INTESTINAL TREFOIL FACTOR
Authors:Lemercinier, X., Muskett, F., Cheeseman, B., McIntosh, P., Carr, M.
Deposit date:2000-10-26
Release date:2000-12-08
Last modified:2017-04-19
Method:SOLUTION NMR
Cite:High-Resolution Solution Structure of Human Intestinal Trefoil Factor and Functional Insights from Detailed Structural Comparisons with the Other Members of the Trefoil Family of Mammalian Cell Motility Factors
Biochemistry, 40, 2001
2C52
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STRUCTURAL DIVERSITY IN CBP P160 COMPLEXES
Descriptor:CREB-BINDING PROTEIN, NUCLEAR RECEPTOR COACTIVATOR 1
Authors:Waters, L.C., Yue, B., Veverka, V., Renshaw, P.S., Bramham, J., Matsuda, S., Frenkiel, T., Kelly, G., Muskett, F.W., Carr, M.D., Heery, D.M.
Deposit date:2005-10-25
Release date:2006-03-15
Last modified:2018-05-02
Method:SOLUTION NMR
Cite:Structural diversity in p160/CREB-binding protein coactivator complexes.
J. Biol. Chem., 281, 2006
2KG7
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STRUCTURE AND FEATURES OF THE COMPLEX FORMED BY THE TUBERCULOSIS VIRULENCE FACTORS RV0287 AND RV0288
Descriptor:Uncharacterized protein esxG (PE family protein), ESAT-6-like protein esxH
Authors:Ilghari, D., Kirsty, L.L., Waters, L.C., Veverka, V.L., Philip, R.S., Carr, M.D.
Deposit date:2009-03-06
Release date:2010-03-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the M. tuberculosis EsxG-EsxH complex: functional implications and comparisons with other M. tuberculosis Esx family complexes
J.Biol.Chem., 2011
5FB8
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STRUCTURE OF INTERLEUKIN-16 BOUND TO THE 14.1 ANTIBODY
Descriptor:Anti-IL-16 antibody 14.1 Fab domain Kappa Chain, Anti-IL-16 antibody 14.1 Fab domain Heavy Chain, Pro-interleukin-16, ...
Authors:Hall, G., Cowan, R., Bayliss, R., Carr, M.
Deposit date:2015-12-14
Release date:2016-06-08
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES.
J.Biol.Chem., 291, 2016
6C97
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CRYSTAL STRUCTURE OF FCRN AT PH3
Descriptor:IgG receptor FcRn large subunit p51, Beta-2-microglobulin, GLYCEROL
Authors:Fox III, D., Fairman, J.W.
Deposit date:2018-01-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
PLoS Biol., 16, 2018
6C98
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CRYSTAL STRUCTURE OF FCRN BOUND TO UCB-84
Descriptor:IgG receptor FcRn large subunit p51, Beta-2-microglobulin, CYSTEINE, ...
Authors:Fox III, D., Lukacs, C.M.
Deposit date:2018-01-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
PLoS Biol., 16, 2018
6C99
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CRYSTAL STRUCTURE OF FCRN BOUND TO UCB-303
Descriptor:IgG receptor FcRn large subunit p51, Beta-2-microglobulin, methyl 7-(3,5-difluorophenyl)-5-(pyridin-3-yl)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate, ...
Authors:Fox III, D., Abendroth, J., Porter, J., Deboves, H.
Deposit date:2018-01-25
Release date:2018-05-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.
PLoS Biol., 16, 2018
1HI7
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NMR SOLUTION STRUCTURE OF THE DISULPHIDE-LINKED HOMODIMER OF HUMAN TFF1, 10 STRUCTURES
Descriptor:PS2 PROTEIN
Authors:Williams, M.A., Feeney, J.
Deposit date:2001-01-03
Release date:2001-01-03
Last modified:2019-04-10
Method:SOLUTION NMR
Cite:The Solution Structure of the Disulphide-Linked Dimeric of the Human Trefoil Protein Tff1
FEBS Lett., 493, 2001
1PS2
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HIGH RESOLUTION NMR SOLUTION STRUCTURE OF HUMAN PS2, 19 STRUCTURES
Descriptor:PS2
Authors:Williams, M.A., Polshakov, V.I., Gargaro, A.R., Feeney, J.
Deposit date:1997-01-07
Release date:1997-07-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein.
J.Mol.Biol., 267, 1997