Author results

2VIF
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CRYSTAL STRUCTURE OF SOCS6 SH2 DOMAIN IN COMPLEX WITH A C-KIT PHOSPHOPEPTIDE
Descriptor:SUPPRESSOR OF CYTOKINE SIGNALLING 6, MAST/STEM CELL GROWTH FACTOR RECEPTOR, 1,2-ETHANEDIOL
Authors:Bullock, A., Pike, A.C.W., Savitsky, P., Keates, T., Pilka, E.S., von Delft, F., Edwards, A., Weigelt, J., Arrowsmith, C.H., Knapp, S.
Deposit date:2007-11-30
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Basis for C-Kit Inhibition by the Suppressor of Cytokine Signaling 6 (Socs6) Ubiquitin Ligase.
J.Biol.Chem., 286, 2011
2BUJ
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CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16 IN COMPLEX WITH STAUROSPORINE
Descriptor:SERINE/THREONINE-PROTEIN KINASE 16, CHLORIDE ION, STAUROSPORINE
Authors:Debreczeni, J.E., Eswaran, J., Bullock, A., Filippakopoulos, P., Kavanagh, K., Amos, A., Fedorov, O., Sobott, F., Ball, L.J., von Delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Knapp, S.
Deposit date:2005-06-13
Release date:2005-07-05
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine
To be Published
2C47
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STRUCTURE OF CASEIN KINASE 1 GAMMA 2
Descriptor:CASEIN KINASE 1 GAMMA 2 ISOFORM, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, MAGNESIUM ION
Authors:Bunkoczi, G., Rellos, P., Das, S., Ugochukwu, E., Fedorov, O., Sobott, F., Eswaran, J., Amos, A., Ball, L., von Delft, F., Bullock, A., Debreczeni, J., Turnbull, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2005-10-16
Release date:2005-11-07
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of Casein Kinase 1 Gamma 2
To be Published
2EXE
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CRYSTAL STRUCTURE OF THE PHOSPHORYLATED CLK3
Descriptor:Dual specificity protein kinase CLK3
Authors:Papagrigoriou, E., Rellos, P., Das, S., Bullock, A., Ball, L.J., Turnbull, A., Savitsky, P., Fedorov, O., Johansson, C., Ugochukwu, E., Sobott, F., von Delft, F., Edwards, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-11-08
Release date:2005-11-15
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the phosphorylated CLK3
TO BE PUBLISHED
2JAM
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CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENT PROTEIN KINASE I G
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1G, POLYPEPTIDE, 1,2-ETHANEDIOL, ...
Authors:Debreczeni, J.E., Bullock, A., Keates, T., Niesen, F.H., Salah, E., Shrestha, L., Smee, C., Sobott, F., Pike, A.C.W., Bunkoczi, G., von Delft, F., Turnbull, A., Weigelt, J., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Knapp, S.
Deposit date:2006-11-29
Release date:2007-03-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Human Calmodulin-Dependent Protein Kinase I G
To be Published
2PPI
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STRUCTURE OF THE BTB (TRAMTRACK AND BRIC A BRAC) DOMAIN OF HUMAN GIGAXONIN
Descriptor:Gigaxonin
Authors:Amos, A., Turnbull, A.P., Tickle, J., Keates, T., Bullock, A., Savitsky, P., Burgess-Brown, N., Debreczeni, J.E., Ugochukwu, E., Umeano, C., Pike, A.C.W., Papagrigoriou, E., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-04-30
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the BTB (Tramtrack and Bric a brac) domain of human Gigaxonin.
To be Published
2X57
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
Descriptor:VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
Authors:Pike, A.C.W., Barr, A.J., Quigley, A., Burgess Brown, N., de Riso, A., Bullock, A., Berridge, G., Muniz, J.R.C., Chaikaud, A., Vollmar, M., Krojer, T., Ugochukwu, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
Deposit date:2010-02-05
Release date:2010-03-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Extracellular Domain of Human Vasoactive Intestinal Polypeptide Receptor 2
To be Published
3I3N
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CRYSTAL STRUCTURE OF THE BTB-BACK DOMAINS OF HUMAN KLHL11
Descriptor:Kelch-like protein 11, THIOCYANATE ION, CHLORIDE ION
Authors:Murray, J.W., Cooper, C.D.O., Krojer, T., Mahajan, P., Salah, E., Keates, T., Savitsky, P., Pike, A.C.W., Roos, A., Muniz, J., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2009-06-30
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the BTB-BACK domains of human KLHL11
To be Published
3MTL
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CRYSTAL STRUCTURE OF THE PCTAIRE1 KINASE IN COMPLEX WITH INDIRUBIN E804
Descriptor:Cell division protein kinase 16, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
Authors:Krojer, T., Sharpe, T.D., Roos, A., Savitsky, P., Amos, A., Ayinampudi, V., Berridge, G., Fedorov, O., Keates, T., Phillips, C., Burgess-Brown, N., Zhang, Y., Pike, A.C.W., Muniz, J., Vollmar, M., Thangaratnarajah, C., Rellos, P., Ugochukwu, E., Filippakopoulos, P., Yue, W., Das, S., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
to be published
3PRY
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CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN HSP90-BETA REFINED AT 2.3 A RESOLUTION
Descriptor:Heat shock protein HSP 90-beta, SULFATE ION, GLYCEROL, ...
Authors:Chaikuad, A., Pilka, E., Sharpe, T.D., Cooper, C.D.O., Phillips, C., Berridge, G., Ayinampudi, V., Fedorov, O., Keates, T., Thangaratnarajah, C., Zimmermann, T., Vollmar, M., Yue, W.W., Che, K.H., Krojer, T., Muniz, J.R.C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-11-30
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
To be Published
3S95
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CRYSTAL STRUCTURE OF THE HUMAN LIMK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE
Descriptor:LIM domain kinase 1, STAUROSPORINE, SODIUM ION, ...
Authors:Beltrami, A., Chaikuad, A., Daga, N., Elkins, J.M., Mahajan, P., Savitsky, P., Vollmar, M., Krojer, T., Muniz, J.R.C., Fedorov, O., Allerston, C.K., Yue, W.W., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2011-05-31
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of the human LIMK1 kinase domain in complex with staurosporine
To be Published
3T7L
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CRYSTAL STRUCTURE OF THE FYVE DOMAIN OF ENDOFIN (ZFYVE16) AT 1.1A RESOLUTION
Descriptor:Zinc finger FYVE domain-containing protein 16, ZINC ION, 1,2-ETHANEDIOL
Authors:Chaikuad, A., Williams, E., Guo, K., Sanvitale, C., Berridge, G., Krojer, T., Muniz, J.R.C., Canning, P., Phillips, C., Shrestha, A., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2011-07-30
Release date:2011-08-31
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Crystal structure of the FYVE domain of endofin (ZFYVE16) at 1.1A resolution
To be Published
3ZDU
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CRYSTAL STRUCTURE OF THE HUMAN CDKL3 KINASE DOMAIN
Descriptor:CYCLIN-DEPENDENT KINASE-LIKE 3, [4-({4-[(3-cyclopentyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile, ZINC ION, ...
Authors:Canning, P., Elkins, J.M., Goubin, S., Mahajan, P., Pike, A.C.W., Quigley, A., MacKenzie, A., Carpenter, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2012-11-30
Release date:2013-03-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the Human Cdkl3 Kinase Domain
To be Published
4ASX
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CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA (ACVR2A) KINASE DOMAIN IN COMPLEX WITH DIHYDRO-BAUERINE C
Descriptor:ACTIVIN RECEPTOR TYPE-2A, 7,8-bis(chloranyl)-9-methyl-3,4-dihydro-2H-pyrido[3,4-b]indol-1-one, 1,2-ETHANEDIOL
Authors:Williams, E., Chaikuad, A., Canning, P., Kochan, G., Mahajan, P., Cooper, C.D.O., Beltrami, A., Krojer, T., Pohl, B., Bracher, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.
Deposit date:2012-05-03
Release date:2012-05-23
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Activin Receptor Type-Iia (Acvr2A) Kinase Domain in Complex with a Beta- Carboline Inhibitor
To be Published
4URJ
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CRYSTAL STRUCTURE OF HUMAN BJ-TSA-9
Descriptor:PROTEIN FAM83A, 1,2-ETHANEDIOL
Authors:Pinkas, D.M., Sanvitale, C., Wang, D., Krojer, T., Kopec, J., Chaikuad, A., Dixon Clarke, S., Berridge, G., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Bullock, A.
Deposit date:2014-06-30
Release date:2014-10-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal Structure of Human Bj-Tsa-9
To be Published
4UUC
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CRYSTAL STRUCTURE OF HUMAN ASB11 ANKYRIN REPEAT DOMAIN
Descriptor:ANKYRIN REPEAT AND SOCS BOX PROTEIN 11
Authors:Pinkas, D.M., Sanvitale, C., Kragh Nielsen, T., Guo, K., Sorrell, F., Berridge, G., Ayinampudi, V., Wang, D., Newman, J.A., Tallant, C., Chaikuad, A., Canning, P., Kopec, J., Krojer, T., Vollmar, M., Allerston, C.K., Chalk, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Bullock, A.
Deposit date:2014-07-25
Release date:2014-08-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Human Asb11 Ankyrin Repeat Domain
To be Published
4UYI
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN SLX4 (BTBD12)
Descriptor:STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX4
Authors:Pinkas, D.M., Sanvitale, C.E., Strain-Damerell, C., Fairhead, M., Wang, D., Tallant, C., Cooper, C.D.O., Sorrell, F.J., Kopec, J., Chaikuad, A., Fitzpatrick, F., Pike, A.C.W., Hozjan, V., Ying, Z., Roos, A.K., Savitsky, P., Bradley, A., Nowak, R., Filippakopoulos, P., Krojer, T., Burgess-Brown, N.A., Marsden, B.D., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2014-09-01
Release date:2014-10-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal Structure of the Btb Domain of Human Slx4 (Btbd12)
To be Published
1XWS
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 KINASE DOMAIN
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, SULFATE ION, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Authors:Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
Deposit date:2004-11-02
Release date:2004-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human PIM1 kinase domain
To be Published
2BIK
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HUMAN PIM1 PHOSPHORYLATED ON SER261
Descriptor:PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, CHLORIDE ION
Authors:Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
Deposit date:2005-01-22
Release date:2005-02-07
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human Pim1 Phosphorylated on Ser261
To be Published
2BIL
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THE HUMAN PROTEIN KINASE PIM1 IN COMPLEX WITH ITS CONSENSUS PEPTIDE PIMTIDE
Descriptor:CONSENSUS PIM1 PEPTIDE PIMTIDE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Authors:Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
Deposit date:2005-01-22
Release date:2005-02-07
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The Human Protein Kinase Pim1 in Complex with its Consensus Peptide Pimtide
To be Published
2BZH
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1
Descriptor:PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, RUTHENIUM-PYRIDOCARBAZOLE-1, 1,2-ETHANEDIOL, ...
Authors:Debreczeni, J.E., Bullock, A., Knapp, S., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A.
Deposit date:2005-08-18
Release date:2005-12-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Human Pim1 in Complex with Ruthenium Organometallic Ligands
To be Published
2BZI
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU2
Descriptor:PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, RU-PYRIDOCARBAZOLE-2
Authors:Debreczeni, J.E., Bullock, A., Knapp, S., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A.
Deposit date:2005-08-18
Release date:2005-12-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Human Pim1 in Complex with Ruthenium Organometallic Ligands
To be Published
2BZJ
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU3
Descriptor:PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, RUTHENIUM-PYRIDOCARBAZOLE-3
Authors:Debreczeni, J.E., Bullock, A., Knapp, S., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A.
Deposit date:2005-08-18
Release date:2005-10-12
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of the Human Pim1 in Complex with Ruthenium Organometallic Ligands
To be Published
2BZK
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH AMPPNP AND PIMTIDE
Descriptor:PIMTIDE, PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Debreczeni, J.E., Bullock, A., Knapp, S., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A.
Deposit date:2005-08-18
Release date:2005-11-03
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of the Human Pim1 in Complex with Amppnp and Pimtide
To be Published
2IHC
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CRYSTAL STRUCTURE OF THE BRIC-A-BRAC (BTB) DOMAIN OF HUMAN BACH1
Descriptor:Transcription regulator protein BACH1
Authors:Amos, A.L., Turnbull, A.P., Bunkoczi, G., Papagrigoriou, E., Gorrec, F., Umeano, C., Bullock, A., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-09-26
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Crystal structure of the bric-a-brac (BTB) domain of human BACH1
To be Published