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3L2C
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BU of 3l2c by Molmil
Crystal Structure of the DNA Binding Domain of FOXO4 Bound to DNA
Descriptor: FOXO consensus binding sequence, minus strand, plus strand, ...
Authors:Boura, E, Silhan, J, Sulc, M, Brynda, J, Obsilova, V, Obsil, T.
Deposit date:2009-12-15
Release date:2009-12-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.868 Å)
Cite:Structure of the human FOXO4-DBD-DNA complex at 1.9 A resolution reveals new details of FOXO binding to the DNA
Acta Crystallogr.,Sect.D, 66, 2010
8BXK
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BU of 8bxk by Molmil
Ntaya virus methyltransferase
Descriptor: Ntaya virus methyltransferase, SINEFUNGIN
Authors:Boura, E, Krafcikova, P.
Deposit date:2022-12-09
Release date:2023-01-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Ntaya virus methyltransferase
To Be Published
5NAS
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BU of 5nas by Molmil
Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide
Descriptor: 14-3-3 protein zeta/delta, Phosphatidylinositol 4-kinase beta
Authors:Boura, E, Eisenreichova, A.
Deposit date:2017-02-28
Release date:2017-03-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide
To Be Published
5LX2
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BU of 5lx2 by Molmil
Lt 14-3-3 in complex with PI4KIIIB peptide
Descriptor: KLTH0G14146p, Phosphatidylinositol 4-kinase beta
Authors:Boura, E, Eisenreichova, A.
Deposit date:2016-09-19
Release date:2016-11-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.579 Å)
Cite:Lt 14-3-3 in complex with PI4KIIIB peptide
To Be Published
8PQO
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BU of 8pqo by Molmil
PITP in complex with the inhibitor VT01545
Descriptor: GLYCEROL, IMIDAZOLE, Inhibitor VT01545, ...
Authors:Boura, E, Eisenreichova, A.
Deposit date:2023-07-11
Release date:2024-05-08
Last modified:2024-07-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:PITP in complex with the inhibitor VT01545
To Be Published
3TOW
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BU of 3tow by Molmil
Crystal Structure of the MABP Domain of MVB12B of Human ESCRT-I Complex
Descriptor: Multivesicular body subunit 12B
Authors:Boura, E, Hurley, J.H.
Deposit date:2011-09-06
Release date:2012-01-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Structural basis for membrane targeting by the MVB12-associated beta-prism domain of the human ESCRT-I MVB12 subunit.
Proc.Natl.Acad.Sci.USA, 109, 2012
6YWA
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BU of 6ywa by Molmil
Human REF STING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)]
Descriptor: 3',3'-c-[2'FdAMP-2'FdAM(PS)], GLYCEROL, Stimulator of interferon genes protein
Authors:Boura, E, Smola, M.
Deposit date:2020-04-29
Release date:2021-05-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.311 Å)
Cite:Human REF STING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)]
To Be Published
6YWB
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BU of 6ywb by Molmil
Human wtSTING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)]
Descriptor: 3',3'-c-[2'FdAMP-2'FdAM(PS)], Stimulator of interferon protein
Authors:Boura, E, Smola, M.
Deposit date:2020-04-29
Release date:2021-05-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Human wtSTING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)]
To Be Published
7A90
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BU of 7a90 by Molmil
WT STING in complex with 3',3'-c-di[2'FdAM(PS)]
Descriptor: 9-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]purin-6-amine, Stimulator of interferon protein
Authors:Boura, E, Smola, M.
Deposit date:2020-09-01
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.185 Å)
Cite:WT STING in complex with 3',3'-c-di[2'FdAM(PS)]
To Be Published
8CQH
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BU of 8cqh by Molmil
Ntaya virus methyltransferase in complex with GTP and SAH
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Genome polyprotein, MAGNESIUM ION, ...
Authors:Boura, E, Krejcova, K.
Deposit date:2023-03-06
Release date:2024-03-13
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase.
Structure, 32, 2024
4K7H
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BU of 4k7h by Molmil
Major capsid protein P1 of the Pseudomonas phage phi6
Descriptor: Major inner protein P1
Authors:Boura, E, Nemecek, D, Plevka, P, Steven, C.A, Hurley, J.H.
Deposit date:2013-04-17
Release date:2013-08-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.5964 Å)
Cite:Subunit Folds and Maturation Pathway of a dsRNA Virus Capsid.
Structure, 21, 2013
5I14
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BU of 5i14 by Molmil
Truncated and mutated T4 lysozyme
Descriptor: NICKEL (II) ION, mutated and truncated T4 lysozyme
Authors:Klima, M, Boura, E.
Deposit date:2016-02-05
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.745 Å)
Cite:Metal ions-binding T4 lysozyme as an intramolecular protein purification tag compatible with X-ray crystallography.
Protein Sci., 26, 2017
2OJ4
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BU of 2oj4 by Molmil
Crystal structure of RGS3 RGS domain
Descriptor: Regulator of G-protein signaling 3
Authors:Boura, E, Obsil, T.
Deposit date:2007-01-12
Release date:2007-01-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3).
J.Struct.Biol., 170, 2010
6QSN
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BU of 6qsn by Molmil
Crystal structure of Yellow fever virus polymerase NS5A
Descriptor: Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Boura, E, Dubankova, A.
Deposit date:2019-02-21
Release date:2019-10-16
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:Structure of the yellow fever NS5 protein reveals conserved drug targets shared among flaviviruses.
Antiviral Res., 169, 2019
6S26
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BU of 6s26 by Molmil
Crystal structure of human wild type STING in complex with 2'-3'-cyclic-GMP-7-deaza-AMP
Descriptor: 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-(4-azanylpyrrolo[2,3-d]pyrimidin-7-yl)-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon protein
Authors:Boura, E, Smola, M, Brynda, J.
Deposit date:2019-06-20
Release date:2019-11-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
J.Med.Chem., 62, 2019
6Y99
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BU of 6y99 by Molmil
hSTING mutant R232K in complex with 2',3'-cGAMP
Descriptor: Stimulator of interferon genes protein, cGAMP
Authors:Boura, E, Smola, M.
Deposit date:2020-03-06
Release date:2021-03-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.984 Å)
Cite:Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
Angew.Chem.Int.Ed.Engl., 60, 2021
6YDB
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BU of 6ydb by Molmil
Human wtSTING in complex with 2',2'-difluoro-3',3'-c-di-GMP
Descriptor: 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-17-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]-1~{H}-purin-6-one, Stimulator of interferon protein
Authors:Boura, E, Smola, M.
Deposit date:2020-03-20
Release date:2021-03-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
Angew.Chem.Int.Ed.Engl., 60, 2021
6YDZ
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BU of 6ydz by Molmil
Human wtSTING in complex with 3',3'-cGAMP
Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Stimulator of interferon protein
Authors:Boura, E, Smola, M.
Deposit date:2020-03-23
Release date:2021-03-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
Angew.Chem.Int.Ed.Engl., 60, 2021
6YEA
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BU of 6yea by Molmil
Human wtSTING in complex with 2',2'-difluoro-3',3'-cGAMP
Descriptor: 2',2'-difluoro-3',3'-cGAMP, Stimulator of interferon protein
Authors:Boura, E, Smola, M.
Deposit date:2020-03-24
Release date:2021-03-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
Angew.Chem.Int.Ed.Engl., 60, 2021
6Z15
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BU of 6z15 by Molmil
Human wtSTING in complex with 3',3'-c-di-AMP
Descriptor: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of interferon protein
Authors:Boura, E, Smola, M.
Deposit date:2020-05-12
Release date:2021-04-21
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
Angew.Chem.Int.Ed.Engl., 60, 2021
6Z0Z
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BU of 6z0z by Molmil
Human wtSTING in complex with 3',3'-c-(2'FdAMP-2'FdAMP)
Descriptor: 2'-fluoro-,3',3'-c-di-AMP, Stimulator of interferon protein
Authors:Boura, E, Smola, M.
Deposit date:2020-05-11
Release date:2021-05-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.499 Å)
Cite:Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
Angew.Chem.Int.Ed.Engl., 60, 2021
9FEH
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BU of 9feh by Molmil
Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the STM957 inhibitor
Descriptor: Transcription factor ETV6,Guanine-N7 methyltransferase nsp14, ZINC ION, ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-pyridin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-3-cyano-~{N}-ethyl-4-methoxy-benzenesulfonamide
Authors:Zilecka, E, Klima, M, Boura, E.
Deposit date:2024-05-20
Release date:2024-08-28
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39.
J Struct Biol X, 10, 2024
8QDJ
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BU of 8qdj by Molmil
Ntaya virus methyltransferase in complex wih Sinefungin
Descriptor: Ntaya virus methyltransferase, SINEFUNGIN, SULFATE ION
Authors:Krejcova, K, Boura, E, Klima, M.
Deposit date:2023-08-29
Release date:2024-09-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase.
Structure, 32, 2024
4PLA
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BU of 4pla by Molmil
Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chimera protein of Phosphatidylinositol 4-kinase type 2-alpha and Lysozyme
Authors:Baumlova, A, Chalupska, D, Boura, E.
Deposit date:2014-05-16
Release date:2014-09-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.771 Å)
Cite:The crystal structure of the phosphatidylinositol 4-kinase II alpha.
Embo Rep., 15, 2014
5FBQ
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BU of 5fbq by Molmil
PI4KB in complex with Rab11 and the MI358 Inhibitor
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta, Ras-related protein Rab-11A, ...
Authors:Chalupska, D, Mejdrova, I, Nencka, R, Boura, E.
Deposit date:2015-12-14
Release date:2016-12-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.789 Å)
Cite:PI4KB in complex with Rab11 and the MI358 Inhibitor
To Be Published

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