6YDB

Human wtSTING in complex with 2',2'-difluoro-3',3'-c-di-GMP

Summary for 6YDB

• Entry DOI: 10.2210/pdb6ydb/pdb
• Descriptor: Stimulator of interferon protein, 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-17-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]-1~{H}-purin-6-one (3 entities in total)
• Functional Keywords: innate immune system, cyclic dinucleotide, sting, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 23883.46

Authors

Boura, E.,Smola, M. (deposition date: 2020-03-20, release date: 2021-03-31, Last modification date: 2024-01-24)

• Primary citation: Smola, M.,Gutten, O.,Dejmek, M.,Kozisek, M.,Evangelidis, T.,Tehrani, Z.A.,Novotna, B.,Nencka, R.,Birkus, G.,Rulisek, L.,Boura, E.; Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.; Angew.Chem.Int.Ed.Engl., 60:10172-10178, 2021; PubMed: 33616279; DOI: 10.1002/anie.202016805

Experimental method

X-RAY DIFFRACTION (2.801 Å)