8PQO

PITP in complex with the inhibitor VT01545

Summary for 8PQO

Entry DOI	10.2210/pdb8pqo/pdb
Descriptor	Phosphatidylinositol transfer protein alpha isoform, (2~{R})-2-azanyl-3-[(2~{S},3~{R})-2-methyl-5-oxidanylidene-pyrrolidin-3-yl]sulfanyl-propanal, IMIDAZOLE, ... (11 entities in total)
Functional Keywords	lipid, phosphatidylinositol, phosphatidylcholine, transfer protein, lipid binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	33097.53
Authors	Boura, E.,Eisenreichova, A. (deposition date: 2023-07-11, release date: 2024-05-08, Last modification date: 2024-05-29)
Primary citation	Kim, Y.J.,Pemberton, J.G.,Eisenreichova, A.,Mandal, A.,Koukalova, A.,Rohilla, P.,Sohn, M.,Konradi, A.W.,Tang, T.T.,Boura, E.,Balla, T. Non-vesicular phosphatidylinositol transfer plays critical roles in defining organelle lipid composition. Embo J., 43:2035-2061, 2024 Cited by PubMed: 38627600 DOI: 10.1038/s44318-024-00096-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation