6Y99

hSTING mutant R232K in complex with 2',3'-cGAMP

Summary for 6Y99

• Entry DOI: 10.2210/pdb6y99/pdb
• Descriptor: Stimulator of interferon genes protein, cGAMP (3 entities in total)
• Functional Keywords: innate immune system, receptor, complex, membrane protein, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 23835.46

Authors

Boura, E.,Smola, M. (deposition date: 2020-03-06, release date: 2021-03-31, Last modification date: 2024-01-24)

• Primary citation: Smola, M.,Gutten, O.,Dejmek, M.,Kozisek, M.,Evangelidis, T.,Tehrani, Z.A.,Novotna, B.,Nencka, R.,Birkus, G.,Rulisek, L.,Boura, E.; Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.; Angew.Chem.Int.Ed.Engl., 60:10172-10178, 2021; PubMed: 33616279; DOI: 10.1002/anie.202016805

Experimental method

X-RAY DIFFRACTION (2.984 Å)