6YDZ

Human wtSTING in complex with 3',3'-cGAMP

Summary for 6YDZ

• Entry DOI: 10.2210/pdb6ydz/pdb
• Descriptor: Stimulator of interferon protein, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one (3 entities in total)
• Functional Keywords: innate immune system, cyclic dinucleotide, sting, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 23863.47

Authors

Boura, E.,Smola, M. (deposition date: 2020-03-23, release date: 2021-03-31, Last modification date: 2024-01-24)

• Primary citation: Smola, M.,Gutten, O.,Dejmek, M.,Kozisek, M.,Evangelidis, T.,Tehrani, Z.A.,Novotna, B.,Nencka, R.,Birkus, G.,Rulisek, L.,Boura, E.; Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.; Angew.Chem.Int.Ed.Engl., 60:10172-10178, 2021; PubMed: 33616279; DOI: 10.1002/anie.202016805

Experimental method

X-RAY DIFFRACTION (2.9 Å)