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2B1G
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
Descriptor:Bifunctional purine biosynthesis protein PURH, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
Deposit date:2005-09-15
Release date:2006-11-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.
J.Biol.Chem., 282, 2007
2B1I
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
Descriptor:Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, [3,4-DIHYDROXY-5R-(2,2,4-TRIOXO-1,2R,3S,4R-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-7-YL)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE
Authors:Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
Deposit date:2005-09-15
Release date:2006-11-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.
J.Biol.Chem., 282, 2007
2IU0
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
Descriptor:BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH, POTASSIUM ION, 1,5-DIHYDROIMIDAZO[4,5-C][1,2,6]THIADIAZIN-4(3H)-ONE 2,2-DIOXIDE
Authors:Xu, L., Chong, Y., Hwang, I., Onofrio, A.D., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
Deposit date:2006-05-26
Release date:2007-02-20
Last modified:2013-03-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structure-Based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase
J.Biol.Chem., 282, 2007
2IU3
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CRYSTAL STRUCTURES OF TRANSITION STATE ANALOGUE INHIBITORS OF INOSINE MONOPHOSPHATE CYCLOHYDROLASE
Descriptor:BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH, POTASSIUM ION, 1,5-DIHYDROIMIDAZO[4,5-C][1,2,6]THIADIAZIN-4(3H)-ONE 2,2-DIOXIDE
Authors:Xu, L., Chong, Y., Hwang, I., D'Onofrio, A., Amore, K., Beardsley, G.P., Li, C., Olson, A.J., Boger, D.L., Wilson, I.A.
Deposit date:2006-05-27
Release date:2007-02-20
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.
J. Biol. Chem., 282, 2007
170D
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SOLUTION STRUCTURE OF A DNA DODECAMER CONTAINING THE ANTI-NEOPLASTIC AGENT ARABINOSYLCYTOSINE: COMBINED USE OF NMR, RESTRAINED MOLECULAR DYNAMICS AND FULL RELAXATION MATRIX REFINEMENT
Descriptor:DNA/RNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*T)-R(P*CAR)-D(P*GP*CP*G)-3')
Authors:Schweitzer, B.I., Mikita, T., Kellogg, G.W., Gardner, K.H., Beardsley, G.P.
Deposit date:1994-03-14
Release date:1994-07-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a DNA dodecamer containing the anti-neoplastic agent arabinosylcytosine: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement.
Biochemistry, 33, 1994
171D
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SOLUTION STRUCTURE OF A DNA DODECAMER CONTAINING THE ANTI-NEOPLASTIC AGENT ARABINOSYLCYTOSINE: COMBINED USE OF NMR, RESTRAINED MOLECULAR DYNAMICS AND FULL RELAXATION MATRIX REFINEMENT
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3')
Authors:Schweitzer, B.I., Mikita, T., Kellogg, G.W., Gardner, K.H., Beardsley, G.P.
Deposit date:1994-03-14
Release date:1994-07-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a DNA dodecamer containing the anti-neoplastic agent arabinosylcytosine: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement.
Biochemistry, 33, 1994
1AC9
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SOLUTION STRUCTURE OF A DNA DECAMER CONTAINING THE ANTIVIRAL DRUG GANCICLOVIR: COMBINED USE OF NMR, RESTRAINED MOLECULAR DYNAMICS, AND FULL RELAXATION REFINEMENT, 6 STRUCTURES
Descriptor:DNA
Authors:Foti, M., Marshalko, S., Schurter, E., Kumar, S., Beardsley, G.P., Schweitzer, B.I.
Deposit date:1997-02-17
Release date:1997-07-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a DNA decamer containing the antiviral drug ganciclovir: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement.
Biochemistry, 36, 1997
1G8M
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CRYSTAL STRUCTURE OF AVIAN ATIC, A BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME IN PURINE BIOSYNTHESIS AT 1.75 ANG. RESOLUTION
Descriptor:AICAR TRANSFORMYLASE-IMP CYCLOHYDROLASE, POTASSIUM ION, GUANOSINE-5'-MONOPHOSPHATE
Authors:Greasley, S.E., Horton, P., Beardsley, G.P., Benkovic, S.J., Wilson, I.A.
Deposit date:2000-11-17
Release date:2001-04-27
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.
Nat.Struct.Biol., 8, 2001
1M9N
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CRYSTAL STRUCTURE OF THE HOMODIMERIC BIFUNCTIONAL TRANSFORMYLASE AND CYCLOHYDROLASE ENZYME AVIAN ATIC IN COMPLEX WITH AICAR AND XMP AT 1.93 ANGSTROMS.
Descriptor:AICAR TRANSFORMYLASE-IMP CYCLOHYDROLASE, POTASSIUM ION, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ...
Authors:Wolan, D.W., Greasly, S.E., Beardsley, G.P., Wilson, I.A.
Deposit date:2002-07-29
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Insights into the Avian AICAR Transformylase Mechanism.
Biochemistry, 41, 2002
1MEJ
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HUMAN GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE DOMAIN AT PH 8.5
Descriptor:Phosphoribosylglycinamide formyltransferase, PHOSPHATE ION, GLYCEROL
Authors:Zhang, Y., Desharnais, J., Greasley, S.E., Beardsley, G.P., Boger, D.L., Wilson, I.A.
Deposit date:2002-08-08
Release date:2002-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human GAR Tfase of low and high pH and with substrate beta-GAR
Biochemistry, 41, 2002
1MEN
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COMPLEX STRUCTURE OF HUMAN GAR TFASE AND SUBSTRATE BETA-GAR
Descriptor:Phosphoribosylglycinamide formyltransferase, GLYCINAMIDE RIBONUCLEOTIDE
Authors:Zhang, Y., Desharnais, J., Greasley, S.E., Beardsley, G.P., Boger, D.L., Wilson, I.A.
Deposit date:2002-08-08
Release date:2002-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal structures of human GAR Tfase of low and high pH and with substrate beta-GAR
Biochemistry, 41, 2002
1MEO
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HUMAN GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE AT PH 4.2
Descriptor:Phosphoribosylglycinamide formyltransferase, PHOSPHATE ION, SULFATE ION
Authors:Zhang, Y., Desharnais, J., Greasley, S.E., Beardsley, G.P., Boger, D.L., Wilson, I.A.
Deposit date:2002-08-08
Release date:2002-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Crystal structures of human GAR Tfase of low and high pH and with substrate beta-GAR
Biochemistry, 41, 2002
1P4R
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CRYSTAL STRUCTURE OF HUMAN ATIC IN COMPLEX WITH FOLATE-BASED INHIBITOR BW1540U88UD
Descriptor:Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ...
Authors:Cheong, C.-G., Greasley, S.E., Horton, P.A., Beardsley, G.P., Wilson, I.A.
Deposit date:2003-04-23
Release date:2004-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates
J.Biol.Chem., 279, 2004
1PL0
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CRYSTAL STRUCTURE OF HUMAN ATIC IN COMPLEX WITH FOLATE-BASED INHIBITOR, BW2315U89UC
Descriptor:Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, XANTHOSINE-5'-MONOPHOSPHATE, ...
Authors:Cheong, C.G., Greasley, S.E., Horton, P.A., Beardsley, G.P., Wilson, I.A.
Deposit date:2003-06-06
Release date:2004-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates.
J.Biol.Chem., 279, 2004
1THZ
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CRYSTAL STRUCTURE OF AVIAN AICAR TRANSFORMYLASE IN COMPLEX WITH A NOVEL INHIBITOR IDENTIFIED BY VIRTUAL LIGAND SCREENING
Descriptor:Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, 2-{(E)-[5-HYDROXY-3-METHYL-1-(2-METHYL-4-SULFOPHENYL)-1H-PYRAZOL-4-YL]DIAZENYL}-4-SULFOBENZOIC ACID
Authors:Xu, L., Li, C., Olson, A.J., Wilson, I.A.
Deposit date:2004-06-01
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.
J.Biol.Chem., 279, 2004