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3HFJ
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BACILLUS ANTHRACIS NICOTINATE MONONUCLEOTIDE ADENYLYTRANSFERASE (NADD) IN COMPLEX WITH INHIBITOR CID 3289443
Descriptor:Nicotinate (Nicotinamide) nucleotide adenylyltransferase, 3-amino-N-(3-fluorophenyl)-6-thiophen-2-ylthieno[2,3-b]pyridine-2-carboxamide, CALCIUM ION
Authors:Zhang, H., Huang, N., Eyobo, Y.
Deposit date:2009-05-11
Release date:2009-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD.
Chem.Biol., 16, 2009
3NSM
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CRYSTAL STRUCTURE OF INSECT BETA-N-ACETYL-D-HEXOSAMINIDASE OFHEX1 FROM OSTRINIA FURNACALIS
Descriptor:N-acetylglucosaminidase
Authors:Zhang, H., Liu, T., Liu, F., Yang, Q., Shen, X.
Deposit date:2010-07-02
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Determinants of an Insect {beta}-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme
J.Biol.Chem., 286, 2011
3NSN
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CRYSTAL STRUCTURE OF INSECT BETA-N-ACETYL-D-HEXOSAMINIDASE OFHEX1 COMPLEXED WITH TMG-CHITOTRIOMYCIN
Descriptor:N-acetylglucosaminidase, TRIACETYLCHITOTRIOSE, 2-deoxy-2-(trimethylammonio)-beta-D-glucopyranose
Authors:Zhang, H., Liu, T., Liu, F., Yang, Q., Shen, X.
Deposit date:2010-07-02
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Determinants of an Insect {beta}-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme
J.Biol.Chem., 286, 2011
3OZP
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CRYSTAL STRUCTURE OF INSECT BETA-N-ACETYL-D-HEXOSAMINIDASE OFHEX1 COMPLEXED WITH PUGNAC
Descriptor:N-acetylglucosaminidase, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE
Authors:Zhang, H., Liu, T., Liu, F., Shen, X., Yang, Q.
Deposit date:2010-09-27
Release date:2011-08-17
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Active-pocket size differentiating insectile from bacterial chitinolytic beta-N-acetyl-D-hexosaminidases
Biochem.J., 438, 2011
3Q6B
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THE HIGH-RESOLUTION AND NEW FORM CRYSTAL STRUCTURE OF BAMA POTRA4-5 FROM E.COLI
Descriptor:Outer membrane protein assembly complex, YaeT protein
Authors:Gao, Z.Q., Zhang, H., Dong, Y.H.
Deposit date:2010-12-31
Release date:2011-08-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:High-resolution structure of a new crystal form of BamA POTRA4-5 from Escherichia coli.
Acta Crystallogr.,Sect.F, 67, 2011
3S6T
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CRYSTAL STRUCTURE OF INSECT BETA-N-ACETYL-D-HEXOSAMINIDASE OFHEX1 V327G COMPLEXED WITH PUGNAC
Descriptor:N-acetylglucosaminidase, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE
Authors:Zhang, H., Liu, T., Yang, Q., Shen, X.
Deposit date:2011-05-26
Release date:2012-04-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Active-pocket size differentiating insectile from bacterial chitinolytic beta-N-acetyl-D-hexosaminidases.
Biochem.J., 438, 2011
4F1R
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STRUCTURE ANALYSIS OF THE GLOBAL METABOLIC REGULATOR CRC FROM PSEUDOMONAS AERUGINOS
Descriptor:Catabolite repression control protein
Authors:Zhang, H., Wei, Y., Gao, Z.Q., Dong, Y.H.
Deposit date:2012-05-07
Release date:2013-02-06
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa.
Iubmb Life, 65, 2013
4GNT
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COMPLEX OF CHREBP AND 14-3-3BETA
Descriptor:14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, SULFATE ION
Authors:Zhang, H., Huang, N.
Deposit date:2012-08-17
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal Structure of Carbohydrate Response Element Binding Protein (ChREBP) in complex with 14-3-3b
To be Published
4HDP
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANTS I50V COMPLEXED WITH INHIBITOR GRL-0519
Descriptor:HIV-1 Protease, (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, SODIUM ION, ...
Authors:Shen, C.H., Zhang, H., Weber, I.T.
Deposit date:2012-10-02
Release date:2013-08-14
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease.
J.Med.Chem., 56, 2013
4HE9
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANTS I54M COMPLEXED WITH INHIBITOR GRL-0519
Descriptor:HIV-1 protease, (3R,3aS,3bR,6aS,7aS)-octahydrodifuro[2,3-b:3',2'-d]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}propyl]carbamate, SODIUM ION, ...
Authors:Shen, C.H., Zhang, H., Weber, I.T.
Deposit date:2012-10-03
Release date:2013-08-21
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease.
J.Med.Chem., 56, 2013
4KTC
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NS3/NS4A PROTEASE WITH INHIBITOR
Descriptor:Serine protease NS3, NS4A peptide, ZINC ION, ...
Authors:Zhang, H., Ballard, J., Vigers, G.P.A., Brandhuber, B.J.
Deposit date:2013-05-20
Release date:2013-08-07
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease.
J.Med.Chem., 57, 2014
4KV1
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CRYSTAL STRUCTURE OF BRD4 BROMODOMAIN 1 IN COMPLEX WITH ACETYLATED REL PEPTIDE
Descriptor:Bromodomain-containing protein 4, Rel peptide
Authors:Zhang, H., Nair, S.K.
Deposit date:2013-05-22
Release date:2013-06-26
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Brd4 maintains constitutively active NF-kappa B in cancer cells by binding to acetylated RelA.
Oncogene, 33, 2014
4KV4
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BRD4 BROMODOMAIN 2 IN COMPLEX WITH ACETYLATED REL PEPTIDE
Descriptor:Bromodomain-containing protein 4, Rel Peptide, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Zhang, H., Nair, S.K.
Deposit date:2013-05-22
Release date:2013-06-26
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Brd4 maintains constitutively active NF-kappa B in cancer cells by binding to acetylated RelA.
Oncogene, 33, 2014
4TMF
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CRYSTAL STRUCTURE OF HUMAN CD38 IN COMPLEX WITH HYDROLYSED COMPOUND JMS713
Descriptor:ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, 5-O-[(R)-{[(S)-[4-(8-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)butoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-alpha-D-ribofuranose
Authors:Zhang, H., Swarbrick, J., Potter, B., Hao, Q.
Deposit date:2014-06-01
Release date:2015-05-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.
J.Med.Chem., 57, 2014
4XQ5
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HUMAN-INFECTING H10N8 INFLUENZA VIRUS RETAINS STRONG PREFERENCE FOR AVIAN-TYPE RECEPTORS
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE
Authors:Tzarum, N., Zhang, H., Zhu, X., Wilson, I.A.
Deposit date:2015-01-19
Release date:2015-04-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.592 Å)
Cite:A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors.
Cell Host Microbe, 17, 2015
4XQO
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CRYSTAL STRUCTURE OF HEMAGGLUTININ FROM JIANGXI-DONGHU (2013) H10N8 INFLUENZA VIRUS IN COMPLEX WITH 6'-SLN
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Tzarum, N., Zhang, H., Zhu, X., Wilson, I.A.
Deposit date:2015-01-19
Release date:2015-04-01
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors.
Cell Host Microbe, 17, 2015
4XQU
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CRYSTAL STRUCTURE OF HEMAGGLUTININ FROM JIANGXI-DONGHU (2013) H10N8 INFLUENZA VIRUS IN COMPLEX WITH 3'-SLN
Descriptor:Hemagglutinin HA1, Hemagglutinin HA2, O-SIALIC ACID, ...
Authors:Tzarum, N., Zhang, H., Zhu, X., Wilson, I.A.
Deposit date:2015-01-20
Release date:2015-04-01
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-type Receptors.
Cell Host Microbe, 17, 2015
5IC0
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STRUCTURAL ANALYSIS OF A TALIN TRIPLE DOMAIN MODULE
Descriptor:Talin-1, 1,2-ETHANEDIOL
Authors:Wu, J., Chang, Y.-C.E., Zhang, H., Brennan, M.L.
Deposit date:2016-02-22
Release date:2016-05-18
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration.
Structure, 24, 2016
5IC1
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STRUCTURAL ANALYSIS OF A TALIN TRIPLE DOMAIN MODULE, E1794Y, E1797Y, Q1801Y MUTANT
Descriptor:Talin-1, 1,2-ETHANEDIOL
Authors:Wu, J., Chang, Y.-C.E., Zhang, H., Huang, Q.-Q.
Deposit date:2016-02-22
Release date:2016-05-18
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration.
Structure, 24, 2016
5V2A
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CRYSTAL STRUCTURE OF FAB H7.167 IN COMPLEX WITH INFLUENZA VIRUS HEMAGGLUTININ FROM A/SHANGHAI/02/2013 (H7N9)
Descriptor:Hemagglutinin, Light chain (kappa) of H7.167 antibody, Heavy chain of H7.167 antibody, ...
Authors:Zhang, H., Zhu, X., Wilson, I.A.
Deposit date:2017-03-03
Release date:2017-04-05
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (4.656 Å)
Cite:H7N9 influenza virus neutralizing antibodies that possess few somatic mutations.
J. Clin. Invest., 126, 2016
5W42
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CRYSTAL STRUCTURE OF HUMAN MONOCLONAL ANTIBODY H3V-47 IN COMPLEX WITH INFLUENZA VIRUS HEMAGGLUTININ FROM A/MINNESOTA/11/2010 (H3N2)
Descriptor:Hemagglutinin, Fab H3v-47 heavy chain, Fab H3v-47 light chain, ...
Authors:Zhang, H., Wilson, I.A.
Deposit date:2017-06-08
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.569 Å)
Cite:A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Nat Commun, 9, 2018
5XOM
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HYDRA FAM20
Descriptor:Glycosaminoglycan xylosylkinase, N-ACETYL-D-GLUCOSAMINE
Authors:Xiao, J., Zhang, H.
Deposit date:2017-05-29
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and evolution of the Fam20 kinases
Nat Commun, 9, 2018
5XRQ
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CRYSTAL STRUCTURE OF HUMAN MONOCLONAL ANTIBODY H3V-47
Descriptor:Fab H3v-47 heavy chain, Fab H3v-47 light chain
Authors:Zhang, H., Willson, I.A.
Deposit date:2017-06-09
Release date:2018-07-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Nat Commun, 9, 2018
5XRS
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CRYSTAL STRUCTURE OF A/MINNESOTA/11/2010 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ IN COMPLEX WITH LSTC
Descriptor:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Zhang, H., Wilson, I.A.
Deposit date:2017-06-09
Release date:2018-07-25
Method:X-RAY DIFFRACTION (2.907 Å)
Cite:A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Nat Commun, 9, 2018
5XRT
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CRYSTAL STRUCTURE OF A/MINNESOTA/11/2010 (H3N2) INFLUENZA VIRUS HEMAGGLUTININ
Descriptor:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Zhang, H., Wilson, I.A.
Deposit date:2017-06-09
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Nat Commun, 9, 2018