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6GY5
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BU of 6gy5 by Molmil
Crystal structure of the kelch domain of human KLHL20 in complex with DAPK1 peptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Death-associated protein kinase 1, ...
Authors:Chen, Z, Hozjan, V, Strain-Damerell, C, Williams, E, Wang, D, Cooper, C.D.O, Sanvitale, C.E, Fairhead, M, Carpenter, E.P, Pike, A.C.W, Krojer, T, Srikannathasan, V, Sorrell, F, Johansson, C, Mathea, S, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
Deposit date:2018-06-28
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.086 Å)
Cite:Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.
Structure, 27, 2019
6HRL
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BU of 6hrl by Molmil
Crystal structure of the Kelch domain of human KLHL17
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Kelch-like protein 17, ...
Authors:Chen, Z, Williams, E, Sorrell, F.J, Newman, J.A, Shrestha, L, Burgess-Brown, N, von Delft, F, Arrowsmith, F, Edwards, C.H, Bountra, C, Bullock, A.N.
Deposit date:2018-09-27
Release date:2018-10-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the Kelch domain of human KLHL17
To Be Published
5NKP
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BU of 5nkp by Molmil
Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide
Descriptor: CHLORIDE ION, CITRIC ACID, Kelch-like protein 3, ...
Authors:Chen, Z, Sorrell, F.J, Pinkas, D.M, Williams, E, Mathea, S, Goubin, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Burgess-Brown, N, Bountra, C, Bullock, A.
Deposit date:2017-03-31
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the human KLHL3 Kelch domain in complex with a WNK3 peptide
To Be Published
1HSH
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BU of 1hsh by Molmil
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
Descriptor: HIV-II PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
Authors:Chen, Z.
Deposit date:1995-03-31
Release date:1996-04-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.
J.Biol.Chem., 269, 1994
1HSI
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BU of 1hsi by Molmil
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
Descriptor: HIV-2 PROTEASE
Authors:Chen, Z.
Deposit date:1995-03-31
Release date:1996-04-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.
J.Biol.Chem., 269, 1994
1HSG
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BU of 1hsg by Molmil
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
Descriptor: HIV-1 PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
Authors:Chen, Z.
Deposit date:1995-03-31
Release date:1996-04-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.
J.Biol.Chem., 269, 1994
4XGA
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BU of 4xga by Molmil
Crystal structure of BamB and BamA P3-5 complex from E.coli
Descriptor: CALCIUM ION, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB
Authors:Chen, Z, Zhan, L.H, Dong, C, Gao, Z.Q, Dong, Y.H.
Deposit date:2014-12-30
Release date:2016-01-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for the interaction of BamB with the POTRA3-4 domains of BamA.
Acta Crystallogr D Struct Biol, 72, 2016
1AHT
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BU of 1aht by Molmil
CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN COMPLEXED WITH HIRUGEN AND P-AMIDINOPHENYLPYRUVATE AT 1.6 ANGSTROMS RESOLUTION
Descriptor: (2S)-3-(4-carbamimidoylphenyl)-2-hydroxypropanoic acid, ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), ...
Authors:Chen, Z.
Deposit date:1995-03-17
Release date:1996-03-17
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution.
Arch.Biochem.Biophys., 322, 1995
1C6V
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BU of 1c6v by Molmil
SIV INTEGRASE (CATALYTIC DOMAIN + DNA BIDING DOMAIN COMPRISING RESIDUES 50-293) MUTANT WITH PHE 185 REPLACED BY HIS (F185H)
Descriptor: PROTEIN (SIU89134), PROTEIN (SIV INTEGRASE)
Authors:Chen, Z, Yan, Y, Munshi, S, Li, Y, Zruygay-Murphy, J, Xu, B, Witmer, M, Felock, P, Wolfe, A, Sardana, V, Emini, E.A, Hazuda, D, Kuo, L.C.
Deposit date:1999-12-21
Release date:2000-12-27
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform.
J.Mol.Biol., 296, 2000
8D6T
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BU of 8d6t by Molmil
Rana catesbeiana saxiphilin mutant - Y558I:STX (co-crystal)
Descriptor: CACODYLATE ION, Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
Authors:Chen, Z, Zakrzewska, S, Minor, D.L.
Deposit date:2022-06-06
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D6P
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BU of 8d6p by Molmil
Rana catesbeiana saxiphilin mutant - Y558A
Descriptor: Saxiphilin
Authors:Chen, Z, Zakrzewska, S, Minor, D.L.
Deposit date:2022-06-06
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D6Q
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BU of 8d6q by Molmil
Rana catesbeiana saxiphilin mutant - Y558I
Descriptor: Saxiphilin
Authors:Chen, Z, Zakrzewska, S, Minor, D.L.
Deposit date:2022-06-06
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D6S
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BU of 8d6s by Molmil
Rana catesbeiana saxiphilin mutant - Y558A:STX (co-crystal)
Descriptor: Saxiphilin, [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate
Authors:Chen, Z, Zakrzewska, S, Minor, D.L.
Deposit date:2022-06-06
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
8D6U
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BU of 8d6u by Molmil
Rana catesbeiana saxiphilin:F-STX (soaked)
Descriptor: (2P)-4-({6-[({[(3aS,4R,7R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methoxy}carbonyl)amino]hexyl}carbamoyl)-2-{[4aP,9(9a)P]-6-hydroxy-3-oxo-3H-xanthen-9-yl}benzoic acid, Saxiphilin
Authors:Chen, Z, Zakrzewska, S, Minor, D.L.
Deposit date:2022-06-06
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family.
Proc.Natl.Acad.Sci.USA, 119, 2022
3KZ1
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BU of 3kz1 by Molmil
Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Rho guanine nucleotide exchange factor 11, ...
Authors:Chen, Z, Sternweis, P.C, Sprang, S.R.
Deposit date:2009-12-07
Release date:2010-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.
J.Biol.Chem., 285, 2010
1EKM
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BU of 1ekm by Molmil
CRYSTAL STRUCTURE AT 2.5 A RESOLUTION OF ZINC-SUBSTITUTED COPPER AMINE OXIDASE OF HANSENULA POLYMORPHA EXPRESSED IN ESCHERICHIA COLI
Descriptor: COPPER AMINE OXIDASE, ZINC ION
Authors:Chen, Z, Schwartz, B, Williams, N.K, Li, R, Klinman, J.P, Mathews, F.S.
Deposit date:2000-03-09
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure at 2.5 A resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli.
Biochemistry, 39, 2000
1FVY
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BU of 1fvy by Molmil
SOLUTION STRUCTURE OF THE OSTEOGENIC 1-31 FRAGMENT OF THE HUMAN PARATHYROID HORMONE
Descriptor: PARATHYROID HORMONE
Authors:Chen, Z.
Deposit date:2000-09-20
Release date:2000-11-22
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the osteogenic 1-31 fragment of the human parathyroid hormone.
Biochemistry, 39, 2000
1SHZ
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BU of 1shz by Molmil
Crystal Structure of the p115RhoGEF rgRGS Domain in A Complex with Galpha(13):Galpha(i1) Chimera
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera, MAGNESIUM ION, ...
Authors:Chen, Z, Singer, W.D, Sternweis, P.C, Sprang, S.R.
Deposit date:2004-02-26
Release date:2005-01-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator.
Nat.Struct.Mol.Biol., 12, 2005
6TTK
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BU of 6ttk by Molmil
Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DVL1, ...
Authors:Chen, Z, Williams, E, Pike, A.C.W, Strain-Damerell, C, Wang, D, Chalk, R, Burgess-Brown, N, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N.
Deposit date:2019-12-27
Release date:2020-02-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.383 Å)
Cite:Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.
Open Biology, 10, 2020
8JT8
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BU of 8jt8 by Molmil
Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ...
Authors:Chen, Z, Fan, L, Wang, S.
Deposit date:2023-06-21
Release date:2024-02-28
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Flexible scaffold-based cheminformatics approach for polypharmacological drug design.
Cell, 187, 2024
8JT6
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BU of 8jt6 by Molmil
5-HT1A-Gi in complex with compound (R)-IHCH-7179
Descriptor: 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Chen, Z, Xu, P, Huang, S, Xu, H.E, Wang, S.
Deposit date:2023-06-21
Release date:2024-02-28
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Flexible scaffold-based cheminformatics approach for polypharmacological drug design.
Cell, 187, 2024
5VF3
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BU of 5vf3 by Molmil
Bacteriophage T4 isometric capsid
Descriptor: Capsid vertex protein gp24, Highly immunogenic outer capsid protein, Major capsid protein, ...
Authors:Chen, Z, Sun, L, Zhang, Z, Fokine, A, Padilla-Sanchez, V, Hanein, D, Jiang, W, Rossmann, M.G, Rao, V.B.
Deposit date:2017-04-06
Release date:2017-09-13
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of the bacteriophage T4 isometric head at 3.3- angstrom resolution and its relevance to the assembly of icosahedral viruses.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8EOI
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BU of 8eoi by Molmil
Structure of a human EMC:human Cav1.2 channel complex in GDN detergent
Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L.
Deposit date:2022-10-03
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.
Nature, 619, 2023
8EOG
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BU of 8eog by Molmil
Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with L-leucine
Descriptor: (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, Z, Mondal, A, Abderemane-Ali, F, Minor, D.L.
Deposit date:2022-10-03
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:EMC chaperone-Ca V structure reveals an ion channel assembly intermediate.
Nature, 619, 2023
8FD7
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BU of 8fd7 by Molmil
Structure of the human L-type voltage-gated calcium channel Cav1.2 complexed with gabapentin
Descriptor: (2R)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl heptadecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(dodecanoyloxy)propyl dodecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Chen, Z, Mondal, A, Minor, D.L.
Deposit date:2022-12-02
Release date:2023-03-22
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for Ca V alpha 2 delta :gabapentin binding.
Nat.Struct.Mol.Biol., 30, 2023

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