Author results

2VN9
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CRYSTAL STRUCTURE OF HUMAN CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II DELTA ISOFORM 1, CAMKD
Descriptor:CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II DELTA CHAIN, PHOSPHATE ION, CHLORIDE ION, ...
Authors:Roos, A.K., Rellos, P., Salah, E., Pike, A.C.W., Fedorov, O., Pilka, E.S., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Knapp, S.
Deposit date:2008-01-31
Release date:2008-02-26
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation.
Plos Biol., 8, 2010
2WUL
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAREDOXIN 5 WITH BOUND GLUTATHIONE IN AN FES CLUSTER
Descriptor:GLUTAREDOXIN RELATED PROTEIN 5, GLUTATHIONE, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Roos, A.K., Johansson, C., Guo, K., Yue, W.W., Pike, A.C.W., Cooper, C.D.O., Pilka, E.S., Kavanagh, K.L., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-10-06
Release date:2009-10-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Crystal Structure of Human Glrx5: Iron Sulphur Cluster Coordination, Tetrameric Assembly and Monomer Activity.
Biochem.J., 433, 2011
2YDX
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CRYSTAL STRUCTURE OF HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 2, BETA SUBUNIT
Descriptor:METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA, RESVERATROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Muniz, J.R.C., Shafqat, N., Pike, A.C.W., Yue, W.W., Vollmar, M., Papagriogriou, V., Roos, A., Gileadi, O., von Delft, F., Kavanagh, K.L., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U.
Deposit date:2011-03-25
Release date:2011-04-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insight Into S-Adenosylmethionine Biosynthesis from the Crystal Structures of the Human Methionine Adenosyltransferase Catalytic and Regulatory Subunits.
Biochem.J., 452, 2013
2YDY
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CRYSTAL STRUCTURE OF HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 2, BETA SUBUNIT IN ORTHORHOMBIC CRYSTAL FORM
Descriptor:METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA, SULFATE ION, CHLORIDE ION
Authors:Yue, W.W., Shafqat, N., Muniz, J.R.C., Pike, A.C.W., Chaikuad, A., Allerston, C.K., Gileadi, O., von Delft, F., Kavanagh, K.L., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U.
Deposit date:2011-03-25
Release date:2011-04-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Insight Into S-Adenosylmethionine Biosynthesis from the Crystal Structures of the Human Methionine Adenosyltransferase Catalytic and Regulatory Subunits.
Biochem.J., 452, 2013
2YGW
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CRYSTAL STRUCTURE OF HUMAN MCD
Descriptor:MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL, UNKNOWN ATOM OR ION, ...
Authors:Vollmar, M., Puranik, S., Krojer, T., Savitsky, P., Allerston, C., Yue, W.W., Chaikuad, A., von Delft, F., Gileadi, O., Kavanagh, K., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Oppermann, U.
Deposit date:2011-04-21
Release date:2012-02-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of Malonyl-Coenzyme a Decarboxylase Provide Insights Into its Catalytic Mechanism and Disease-Causing Mutations.
Structure, 21, 2013
3B7O
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CRYSTAL STRUCTURE OF THE HUMAN TYROSINE PHOSPHATASE SHP2 (PTPN11) WITH AN ACCESSIBLE ACTIVE SITE
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, D-MALATE
Authors:Ugochukwu, E., Barr, A., Patel, A., King, O., Niesen, F., Salah, E., Savitsky, P., Pilka, E.S., Elkins, J., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-13
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
3BIC
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CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA MUTASE
Descriptor:Methylmalonyl-CoA mutase, mitochondrial precursor, CHLORIDE ION
Authors:Ugochukwu, E., Kochan, G., Pantic, N., Parizotto, E., Pilka, E.S., Pike, A.C.W., Gileadi, O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-11-30
Release date:2007-12-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.
J.Biol.Chem., 285, 2010
3E04
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CRYSTAL STRUCTURE OF HUMAN FUMARATE HYDRATASE
Descriptor:Fumarate hydratase, 1,2-ETHANEDIOL
Authors:Kavanagh, K.L., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-07-30
Release date:2008-08-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human fumarate hydratase
TO BE PUBLISHED
4BXF
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60S RIBOSOMAL PROTEIN L27A HISTIDINE HYDROXYLASE (MINA53 Y209C) IN COMPLEX WITH MN(II), 2-OXOGLUTARATE (2OG) AND 60S RIBOSOMAL PROTEIN L27A (RPL27A G37C) PEPTIDE FRAGMENT
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE MINA, 60S RIBOSOMAL PROTEIN L27A, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2013-07-10
Release date:2014-05-14
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCJ
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN APO FORM
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 1,2-ETHANEDIOL
Authors:Chowdhury, R., Ge, W., Clifton, I.J., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCK
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN COMPLEX WITH MN(II) AND N-OXALYLGLYCINE (NOG)
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, MANGANESE (II) ION, N-OXALYLGLYCINE, ...
Authors:Chowdhury, R., Ge, W., Clifton, I.J., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCL
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X-RAY STRUCTURE OF E. COLI YCFD
Descriptor:50S RIBOSOMAL PROTEIN L16 ARGININE HYDROXYLASE, MANGANESE (II) ION, SULFATE ION
Authors:McDonough, M.A., Ho, C.H., Kershaw, N.J., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-04-30
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCM
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66) IN COMPLEX WITH MN(II), N-OXALYLGLYCINE (NOG) AND 60S RIBOSOMAL PROTEIN L8 (RPL8 G220C) PEPTIDE FRAGMENT (COMPLEX-1)
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 60S RIBOSOMAL PROTEIN L8, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCN
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66 L299C/C300S) IN COMPLEX WITH MN(II), N-OXALYLGLYCINE (NOG) AND 60S RIBOSOMAL PROTEIN L8 (RPL8 G220C) PEPTIDE FRAGMENT (COMPLEX-2)
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 60S RIBOSOMAL PROTEIN L8, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CCO
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60S RIBOSOMAL PROTEIN L8 HISTIDINE HYDROXYLASE (NO66 S373C) IN COMPLEX WITH MN(II), N-OXALYLGLYCINE (NOG) AND 60S RIBOSOMAL PROTEIN L8 (RPL8 G214C) PEPTIDE FRAGMENT (COMPLEX-3)
Descriptor:BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, 60S RIBOSOMAL PROTEIN L8, MANGANESE (II) ION, ...
Authors:Chowdhury, R., Schofield, C.J.
Deposit date:2013-10-23
Release date:2014-05-14
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CSW
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RHODOTHERMUS MARINUS YCFD-LIKE RIBOSOMAL PROTEIN L16 ARGINYL HYDROXYLASE
Descriptor:CUPIN 4 FAMILY PROTEIN, CITRIC ACID, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ...
Authors:McDonough, M.A., Sekirnik, R., Schofield, C.J.
Deposit date:2014-03-11
Release date:2014-04-09
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.821 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4CUG
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RHODOTHERMUS MARINUS YCFD-LIKE RIBOSOMAL PROTEIN L16 ARGINYL HYDROXYLASE IN COMPLEX SUBSTRATE FRAGMENT
Descriptor:CUPIN 4 FAMILY PROTEIN, 50S RIBOSOMAL PROTEIN L16, MANGANESE (II) ION, ...
Authors:McDonough, M.A., Sekirnik, R., Schofield, C.J.
Deposit date:2014-03-18
Release date:2014-04-16
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 510, 2014
4KS9
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CRYSTAL STRUCTURE OF MALONYL-COA DECARBOXYLASE (RMET_2797) FROM CUPRIAVIDUS METALLIDURANS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET CRR76
Descriptor:Malonyl-CoA decarboxylase, MAGNESIUM ION
Authors:Forouhar, F., Tran, T.H., Lew, S., Seetharaman, J., Xiao, R., Acton, T.B., Everett, J.K., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-05-17
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure, 21, 2013
4KSA
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CRYSTAL STRUCTURE OF MALONYL-COA DECARBOXYLASE FROM RHODOPSEUDOMONAS PALUSTRIS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET RPR127
Descriptor:Malonyl-CoA decarboxylase, MAGNESIUM ION
Authors:Forouhar, F., Neely, H., Seetharaman, J., Sahdev, S., Xiao, R., Patel, D.J., Ciccosanti, C., Wang, D., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-05-17
Release date:2013-06-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure, 21, 2013
4KSF
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CRYSTAL STRUCTURE OF MALONYL-COA DECARBOXYLASE FROM AGROBACTERIUM VITIS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET RIR35
Descriptor:Malonyl-CoA decarboxylase, NICKEL (II) ION, CHLORIDE ION
Authors:Forouhar, F., Neely, H., Seetharaman, J., Sahdev, S., Xiao, R., Ciccosanti, C., Lee, D., Everett, J.K., Acton, T.B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-05-17
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure, 21, 2013
4LIT
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STRUCTURE OF YCFD A RIBOSOMAL OXYGENASE FROM ESCHERICHIA COLI IN COMPLEX WITH COBALT AND 2-OXOGLUTARATE.
Descriptor:50S ribosomal protein L16 arginine hydroxylase, COBALT (II) ION, 2-OXOGLUTARIC ACID
Authors:Brissett, N.C., Doherty, A.J.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
4LIU
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STRUCTURE OF YCFD, A RIBOSOMAL OXYGENASE FROM ESCHERICHIA COLI.
Descriptor:50S ribosomal protein L16 arginine hydroxylase, TRIS(HYDROXYETHYL)AMINOMETHANE, PHOSPHATE ION
Authors:Brissett, N.C., Doherty, A.J., Fox, G.C.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
4LIV
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STRUCTURE OF YCFD, A RIBOSOMAL OXYGENASE FROM ESCHERICHIA COLI IN COMPLEX WITH COBALT AND SUCCINIC ACID.
Descriptor:50S ribosomal protein L16 arginine hydroxylase, COBALT (II) ION, SUCCINIC ACID
Authors:Brissett, N.C., Doherty, A.J.
Deposit date:2013-07-03
Release date:2014-05-14
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Nature, 509, 2014
5LY1
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JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND MACROCYCLIC PEPTIDE INHIBITOR CP2 (13-MER)
Descriptor:Lysine-specific demethylase 4A, CP2, NICKEL (II) ION, ...
Authors:King, O.N.F., Chowdhury, R., Kawamura, A., Schofield, C.J.
Deposit date:2016-09-23
Release date:2017-04-12
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017
5LY2
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JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND MACROCYCLIC PEPTIDE INHIBITOR CP2_R6KME3 (13-MER)
Descriptor:Lysine-specific demethylase 4A, CP2_R6Kme3, NICKEL (II) ION, ...
Authors:CHOWDHURY, R., Madden, S.K., Hopkinson, R., SCHOFIELD, C.J.
Deposit date:2016-09-23
Release date:2017-04-12
Last modified:2017-04-19
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.
Nat Commun, 8, 2017