Author results

6NBF
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CRYO-EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG-ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN
Descriptor:Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ...
Authors:Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y.
Deposit date:2018-12-07
Release date:2019-04-17
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
6NBH
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CRYO-EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG-ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN
Descriptor:Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ...
Authors:Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y.
Deposit date:2018-12-07
Release date:2019-04-17
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
6NBI
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CRYO-EM STRUCTURE OF PARATHYROID HORMONE RECEPTOR TYPE 1 IN COMPLEX WITH A LONG-ACTING PARATHYROID HORMONE ANALOG AND G PROTEIN
Descriptor:Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, ...
Authors:Zhao, L.-H., Ma, S., Sutkeviciute, I., Shen, D.-D., Zhou, X.E., de Waal, P.P., Li, C.-Y., Kang, Y., Clark, L.J., Jean-Alphonse, F.G., White, A.D., Xiao, K., Yang, D., Jiang, Y., Watanabe, T., Gardella, T.J., Melcher, K., Wang, M.-W., Vilardaga, J.-P., Xu, H.E., Zhang, Y.
Deposit date:2018-12-07
Release date:2019-04-17
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure and dynamics of the active human parathyroid hormone receptor-1.
Science, 364, 2019
3L3X
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CRYSTAL STRUCTURE OF DHT-BOUND ANDROGEN RECEPTOR IN COMPLEX WITH THE FIRST MOTIF OF STEROID RECEPTOR COACTIVATOR 3
Descriptor:Androgen receptor, Nuclear receptor coactivator 3, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Zhou, X.E., Suino-Powell, K.M., Li, J., He, A., MacKeigan, J.P., Melcher, K., Yong, E.-L., Xu, H.E.
Deposit date:2009-12-18
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor.
J.Biol.Chem., 285, 2010
3L3Z
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CRYSTAL STRUCTURE OF DHT-BOUND ANDROGEN RECEPTOR IN COMPLEX WITH THE THIRD MOTIF OF STEROID RECEPTOR COACTIVATOR 3
Descriptor:Androgen receptor, Nuclear receptor coactivator 3, 5-ALPHA-DIHYDROTESTOSTERONE
Authors:Zhou, X.E., Suino-Powell, K.M., Li, J., He, A., MacKeigan, J.P., Melcher, K., Yong, E.-L., Xu, H.E.
Deposit date:2009-12-18
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor.
J.Biol.Chem., 285, 2010
3UC3
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THE CRYSTAL STRUCTURE OF SNF1-RELATED KINASE 2.3
Descriptor:Serine/threonine-protein kinase SRK2I, COBALT (II) ION
Authors:Zhou, X.E., Ng, L.-M., Soon, F.-F., Kovach, A., Suino-Powell, K.M., Li, J., Melcher, K., Xu, H.E.
Deposit date:2011-10-25
Release date:2011-12-14
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases.
Proc.Natl.Acad.Sci.USA, 108, 2011
3UC4
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THE CRYSTAL STRUCTURE OF SNF1-RELATED KINASE 2.6
Descriptor:Serine/threonine-protein kinase SRK2E
Authors:Zhou, X.E., Ng, L.-M., Soon, F.-F., Kovach, A., Suino-Powell, K.M., Li, J., Melcher, K., Xu, H.E.
Deposit date:2011-10-26
Release date:2011-12-14
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases.
Proc.Natl.Acad.Sci.USA, 108, 2011
3UJG
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CRYSTAL STRUCTURE OF SNRK2.6 IN COMPLEX WITH HAB1
Descriptor:Serine/threonine-protein kinase SRK2E, Protein phosphatase 2C 16, SULFATE ION, ...
Authors:Zhou, X.E., Soon, F.-F., Ng, L.-M., Kovach, A., Tan, M.H.E., Suino-Powell, K.M., He, Y., Xu, Y., Brunzelle, J.S., Li, J., Melcher, K., Xu, H.E.
Deposit date:2011-11-07
Release date:2012-02-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.
Science, 335, 2012
3UJK
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CRYSTAL STRUCTURE OF PROTEIN PHOSPHATASE ABI2
Descriptor:Protein phosphatase 2C 77, MAGNESIUM ION
Authors:Zhou, X.E., Soon, F.-F., Ng, L.-M., Kovach, A., Tan, M.H.E., Suino-Powell, K.M., He, Y., Xu, Y., Brunzelle, J.S., Li, J., Melcher, K., Xu, H.E.
Deposit date:2011-11-07
Release date:2012-02-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.
Science, 335, 2012
3UJL
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CRYSTAL STRUCTURE OF ABSCISIC ACID BOUND PYL2 IN COMPLEX WITH TYPE 2C PROTEIN PHOSPHATASE ABI2
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 77, (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, ...
Authors:Zhou, X.E., Soon, F.-F., Ng, L.-M., Kovach, A., Tan, M.H.E., Suino-Powell, K.M., He, Y., Xu, Y., Brunzelle, J.S., Li, J., Melcher, K., Xu, H.E.
Deposit date:2011-11-07
Release date:2012-02-15
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.
Science, 335, 2012
3UP0
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NUCLEAR RECEPTOR DAF-12 FROM HOOKWORM ANCYLOSTOMA CEYLANICUM IN COMPLEX WITH (25S)-DELTA7-DAFACHRONIC ACID
Descriptor:aceDAF-12, Nuclear receptor coactivator 2, (5beta,14beta,17alpha,25S)-3-oxocholest-7-en-26-oic acid
Authors:Zhi, X., Zhou, X.E., Melcher, K., Motola, D.L., Gelmedin, V., Hawdon, J., Kliewer, S.A., Mangelsdorf, D.J., Xu, H.E.
Deposit date:2011-11-17
Release date:2011-12-14
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes.
J.Biol.Chem., 287, 2012
3UP3
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NUCLEAR RECEPTOR DAF-12 FROM HOOKWORM ANCYLOSTOMA CEYLANICUM IN COMPLEX WITH (25S)-CHOLESTENOIC ACID
Descriptor:aceDAF-12, Nuclear receptor coactivator 2, (8alpha,10alpha,25S)-3-hydroxycholesta-3,5-dien-26-oic acid, ...
Authors:Zhi, X., Zhou, X.E., Melcher, K., Motola, D.L., Gelmedin, V., Hawdon, J., Kliewer, S.A., Mangelsdorf, D.J., Xu, H.E.
Deposit date:2011-11-17
Release date:2011-12-14
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes.
J.Biol.Chem., 287, 2012
4IAQ
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CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF 5-HT1B-BRIL IN COMPLEX WITH DIHYDROERGOTAMINE (PSI COMMUNITY TARGET)
Descriptor:Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Dihydroergotamine
Authors:Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G.W., Liu, W., Huang, X., Vardy, E., McCorvy, J.D., Gao, X., Zhou, E.X., Melcher, K., Zhang, C., Bai, F., Yang, H., Yang, L., Jiang, H., Roth, B.L., Cherezov, V., Stevens, R.C., Xu, H.E., GPCR Network (GPCR)
Deposit date:2012-12-07
Release date:2013-03-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for molecular recognition at serotonin receptors.
Science, 340, 2013
4IAR
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CRYSTAL STRUCTURE OF THE CHIMERIC PROTEIN OF 5-HT1B-BRIL IN COMPLEX WITH ERGOTAMINE (PSI COMMUNITY TARGET)
Descriptor:Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Ergotamine, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Wang, C., Jiang, Y., Ma, J., Wu, H., Wacker, D., Katritch, V., Han, G.W., Liu, W., Huang, X., Vardy, E., McCorvy, J.D., Gao, X., Zhou, E.X., Melcher, K., Zhang, C., Bai, F., Yang, H., Yang, L., Jiang, H., Roth, B.L., Cherezov, V., Stevens, R.C., Xu, H.E., GPCR Network (GPCR)
Deposit date:2012-12-07
Release date:2013-03-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for molecular recognition at serotonin receptors.
Science, 340, 2013
4IH1
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CRYSTAL STRUCTURE OF KARRIKIN INSENSITIVE 2 (KAI2) FROM ARABIDOPSIS THALIANA
Descriptor:Hydrolase, alpha/beta fold family protein
Authors:Zhou, X.E., Zhao, L.-H., Wu, Z.-S., Yi, W., Li, S., Li, Y., Xu, Y., Xu, T.-H., Liu, Y., Chen, R.-Z., Kovach, A., Kang, Y., Hou, L., He, Y., Zhang, C., Melcher, K., Xu, H.E.
Deposit date:2012-12-18
Release date:2013-01-30
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14.
Cell Res., 23, 2013
4IH4
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CRYSTAL STRUCTURE OF ARABIDOPSIS DWARF14 ORTHOLOGUE, ATD14
Descriptor:AT3g03990/T11I18_10
Authors:Zhou, X.E., Zhao, L.-H., Wu, Z.-S., Yi, W., Li, S., Li, Y., Xu, Y., Xu, T.-H., Liu, Y., Chen, R.-Z., Kovach, A., Kang, Y., Hou, L., He, Y., Zhang, C., Melcher, K., Xu, H.E.
Deposit date:2012-12-18
Release date:2013-01-30
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14.
Cell Res., 23, 2013
4IH9
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CRYSTAL STRUCTURE OF RICE DWARF14 (D14)
Descriptor:Dwarf 88 esterase
Authors:Zhou, X.E., Zhao, L.-H., Wu, Z.-S., Yi, W., Li, S., Li, Y., Xu, Y., Xu, T.-H., Liu, Y., Chen, R.-Z., Kovach, A., Kang, Y., Hou, L., He, Y., Zhang, C., Melcher, K., Xu, H.E.
Deposit date:2012-12-18
Release date:2013-01-30
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14.
Cell Res., 23, 2013
4IHA
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CRYSTAL STRUCTURE OF RICE DWARF14 (D14) IN COMPLEX WITH A GR24 HYDROLYSIS INTERMEDIATE
Descriptor:Dwarf 88 esterase, (2R,3R)-2,4,4-trihydroxy-3-methylbutanal
Authors:Zhou, X.E., Zhao, L.-H., Wu, Z.-S., Yi, W., Li, S., Li, Y., Xu, Y., Xu, T.-H., Liu, Y., Chen, R.-Z., Kovach, A., Kang, Y., Hou, L., He, Y., Zhang, C., Melcher, K., Xu, H.E.
Deposit date:2012-12-18
Release date:2013-01-23
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of two phytohormone signal-transducing alpha / beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14.
Cell Res., 23, 2013
4IUA
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CRYSTAL STRUCTURE OF THE NK2 FRAGMENT (31-290) OF THE MOUSE HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR
Descriptor:Hepatocyte growth factor, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION
Authors:Tolbert, W.D., Zhou, E., Kovach, A., Melcher, K., Xu, H.E.
Deposit date:2013-01-20
Release date:2013-02-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal Structure of the NK2 Fragment of the mouse Hepatocyte Growth Factor/Scatter Factor
To be Published
4LEU
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CRYSTAL STRUCTURE OF THA8-LIKE PROTEIN FROM ARABIDOPSIS THALIANA
Descriptor:Pentatricopeptide repeat-containing protein At3g46870
Authors:Ke, J., Chen, R.Z., Ban, T., Brunzelle, J.S., Gu, X., Kang, Y., Melcher, K., Zhu, J.K., Xu, H.E.
Deposit date:2013-06-26
Release date:2013-09-25
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a PLS-class Pentatricopeptide Repeat Protein Provides Insights into Mechanism of RNA Recognition.
J.Biol.Chem., 288, 2013
4LG5
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ABA-MIMICKING LIGAND QUINABACTIN IN COMPLEX WITH ABA RECEPTOR PYL2 AND PP2C HAB1
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 16, Quinabactin, ...
Authors:Zhou, X.E., Gao, M., Liu, X., Zhang, Y., Xue, X., Melcher, K., Gao, P., Wang, F., Zeng, L., Zhao, Y., Zhao, Y., Deng, P., Zhong, D., Zhu, J.-K., Xu, Y., Xu, H.E.
Deposit date:2013-06-27
Release date:2013-08-14
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants.
Cell Res., 23, 2013
4LGA
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ABA-MIMICKING LIGAND N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE IN COMPLEX WITH ABA RECEPTOR PYL2 AND PP2C HAB1
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 16, N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)-1-phenylmethanesulfonamide, ...
Authors:Zhou, X.E., Gao, M., Liu, X., Zhang, Y., Xue, X., Melcher, K., Gao, P., Wang, F., Zeng, L., Zhao, Y., Zhao, Y., Deng, P., Zhong, D., Zhu, J.-K., Xu, Y., Xu, H.E.
Deposit date:2013-06-27
Release date:2013-08-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants.
Cell Res., 23, 2013
4LGB
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ABA-MIMICKING LIGAND N-(1-METHYL-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-(4-METHYLPHENYL)METHANESULFONAMIDE IN COMPLEX WITH ABA RECEPTOR PYL2 AND PP2C HAB1
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 16, N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-1-(4-methylphenyl)methanesulfonamide, ...
Authors:Zhou, X.E., Gao, M., Liu, X., Zhang, Y., Xue, X., Melcher, K., Gao, P., Wang, F., Zeng, L., Zhao, Y., Zhao, Y., Deng, P., Zhong, D., Zhu, J.-K., Xu, Y., Xu, H.E.
Deposit date:2013-06-27
Release date:2013-08-14
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants.
Cell Res., 23, 2013
4LOG
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THE CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR PNR LIGAND BINDING DOMAIN FUSED WITH MBP
Descriptor:Maltose ABC transporter periplasmic protein and NR2E3 protein chimeric construct
Authors:Tan, M.E., Zhou, X.E., Soon, F.-F., Li, X., Li, J., Yong, E.-L., Melcher, K., Xu, H.E.
Deposit date:2013-07-12
Release date:2013-10-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation.
Plos One, 8, 2013
4LRH
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CRYSTAL STRUCTURE OF HUMAN FOLATE RECEPTOR ALPHA IN COMPLEX WITH FOLIC ACID
Descriptor:Folate receptor alpha, FOLIC ACID, N-ACETYL-D-GLUCOSAMINE
Authors:Ke, J., Chen, C., Zhou, X.E., Yi, W., Brunzelle, J.S., Li, J., Young, E.-L., Xu, H.E., Melcher, K.
Deposit date:2013-07-19
Release date:2013-07-31
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for molecular recognition of folic acid by folate receptors.
Nature, 500, 2013