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4OCZ
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CRYSTAL STRUCTURE OF HUMAN SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH 1-(1-ISOBUTYRYLPIPERIDIN-4-YL)-3-(4-(TRIFLUOROMETHYL)PHENYL)UREA
Descriptor:Bifunctional epoxide hydrolase 2, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Lee, K.S.S., Liu, J., Wagner, K.M., Pakhomova, S., Dong, H., Morriseau, C., Fu, S.H., Yang, J., Wang, P., Ulu, A., Mate, C., Nguyen, L., Wullf, H., Eldin, M.L., Mara, A.A., Newcomer, M.E., Zeldin, D.C., Hammock, B.D.
Deposit date:2014-01-09
Release date:2014-09-24
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
J.Med.Chem., 57, 2014
4OD0
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CRYSTAL STRUCTURE OF HUMAN SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH 1-(1-PROPANOYLPIPERIDIN-4-YL)-3-[4-(TRIFLUOROMETHOXY)PHENYL]UREA
Descriptor:Bifunctional epoxide hydrolase 2, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Lee, K.S.S., Liu, J., Wagner, K.M., Pakhomova, S., Dong, H., Morisseau, C., Fu, S.H., Yang, J., Wang, P., Ulu, A., Mate, C., Nguyen, L., Wullf, H., Eldin, M.L., Mara, A.A., Newcomer, M.E., Zeldin, D.C., Hammock, B.D.
Deposit date:2014-01-09
Release date:2014-09-24
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy.
J.Med.Chem., 57, 2014
4KNB
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C-MET IN COMPLEX WITH OSI LIGAND
Descriptor:Hepatocyte growth factor receptor, 7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine, GAMMA-BUTYROLACTONE
Authors:Wang, J., Steinig, A.G., Li, A.H., Chen, X., Dong, H., Ferraro, C., Jin, M., Kadalbajoo, M., Kleinberg, A., Stolz, K.M., Tavares-Greco, P.A., Wang, T., Albertella, M.R., Peng, Y., Crew, L., Kahler, J.
Deposit date:2013-05-09
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.
Bioorg.Med.Chem.Lett., 23, 2013
3LKZ
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STRUCTURAL AND FUNCTIONAL ANALYSES OF A CONSERVED HYDROPHOBIC POCKET OF FLAVIVIRUS METHYLTRANSFERASE
Descriptor:Non-structural protein 5, SINEFUNGIN, GLYCEROL
Authors:Liu, L.H., Li, H.M.
Deposit date:2010-01-28
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase.
J.Biol.Chem., 285, 2010
3Q6S
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THE CRYSTAL STRUCTURE OF THE HETEROCHROMATIN PROTEIN 1 BETA CHROMOSHADOW DOMAIN COMPLEXED WITH A PEPTIDE FROM SHUGOSHIN 1
Descriptor:Chromobox protein homolog 1, Shugoshin-like 1
Authors:Brautigam, C.A., Chaudhary, J., Yu, H.
Deposit date:2011-01-03
Release date:2011-12-14
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.
Mol Biol Cell, 22, 2011
2OY0
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CRYSTAL STRUCTURE OF THE WEST NILE VIRUS METHYLTRANSFERASE
Descriptor:Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, H.M., Zhao, Y.W., Guo, Y., Shi, P.Y.
Deposit date:2007-02-21
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and Function of Flavivirus NS5 Methyltransferase.
J.Virol., 81, 2007
5ZVD
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THE CRYSTAL STRUCTURE OF NSUN6 FROM PYROCOCCUS HORIKOSHII
Descriptor:389aa long hypothetical nucleolar protein
Authors:Li, J., Liu, R.J., Wang, E.D.
Deposit date:2018-05-10
Release date:2018-12-12
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.594 Å)
Cite:Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019
5ZVE
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THE CRYSTAL STRUCTURE OF NSUN6 FROM PYROCOCCUS HORIKOSHII WITH SAH
Descriptor:389aa long hypothetical nucleolar protein, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Li, J., Liu, R.J., Wang, E.D.
Deposit date:2018-05-10
Release date:2018-12-12
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.178 Å)
Cite:Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019
5ZVG
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THE CRYSTAL STRUCTURE OF NSUN6 FROM PYROCOCCUS HORIKOSHII WITH SAM
Descriptor:389aa long hypothetical nucleolar protein, S-ADENOSYLMETHIONINE
Authors:Li, J., Liu, R.J., Wang, E.D.
Deposit date:2018-05-10
Release date:2018-12-12
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019
5ZVH
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THE CRYSTAL STRUCTURE OF NSUN6 FROM PYROCOCCUS HORIKOSHII WITH SFG
Descriptor:389aa long hypothetical nucleolar protein, SINEFUNGIN
Authors:Li, J., Liu, R.J., Wang, E.D.
Deposit date:2018-05-10
Release date:2018-12-12
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Archaeal NSUN6 catalyzes m5C72 modification on a wide-range of specific tRNAs.
Nucleic Acids Res., 47, 2019
3N6L
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THE CRYSTAL STRUCUTRE OF RNA-DEPENDENT RNA POLYMERASE OF EV71 VIRUS
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION
Authors:Wu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3N6M
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CRYSTAL STRUCTURE OF EV71 RDRP IN COMPLEX WITH GTP
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Wu, Y., Lou, Z.Y., Miao, Y., Yu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3N6N
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CRYSTAL STRUCTURE OF EV71 RDRP IN COMPLEX WITH BR-UTP
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION, 5-bromouridine 5'-(tetrahydrogen triphosphate)
Authors:Wu, Y., Lou, Z.Y., Miao, Y., Yu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3P8Z
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DENGUE METHYLTRANSFERASE BOUND TO A SAM-BASED INHIBITOR
Descriptor:Non-structural protein 5, (S)-2-amino-4-(((2S,3S,4R,5R)-5-(6-(3-chlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Noble, C.G., Yap, L.J., Lescar, J.
Deposit date:2010-10-15
Release date:2010-12-08
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
3P97
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO THE SUBSTRATE S-ADENOSYL METHIONINE
Descriptor:Non-structural protein 5, S-ADENOSYLMETHIONINE
Authors:Noble, C.G., Yap, L.J., Lescar, J.
Deposit date:2010-10-16
Release date:2010-12-08
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small molecule inhibitors that selectively block dengue virus methyltransferase
J.Biol.Chem., 286, 2011
4L3P
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CRYSTAL STRUCTURE OF 2-(1-BENZOTHIOPHEN-7-YL)-4-[1-(PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL]FURO[2,3-C]PYRIDIN-7-AMINE BOUND TO TAK1-TAB1
Descriptor:Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera, 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine
Authors:Wang, J., Hornberger, K.R., Crew, A.P., Steinbacher, S., Maskos, K., Moertl, M.
Deposit date:2013-06-06
Release date:2013-06-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
Bioorg.Med.Chem.Lett., 23, 2013
4L52
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CRYSTAL STRUCTURE OF 1-(4-{4-[7-AMINO-2-(1,2,3-BENZOTHIADIAZOL-7-YL)FURO[2,3-C]PYRIDIN-4-YL]-1H-PYRAZOL-1-YL}PIPERIDIN-1-YL)ETHAN-1-ONE BOUND TO TAK1-TAB1
Descriptor:Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera, 1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]-1H-pyrazol-1-yl}piperidin-1-yl)ethanone
Authors:Wang, J., Hornberger, K.R., Crew, A.P., Jestel, A., Maskos, K., Moertl, M.
Deposit date:2013-06-10
Release date:2013-07-03
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
Bioorg.Med.Chem.Lett., 23, 2013
4R8R
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DENGUE VIRUS SEROTYPE 3 METHYLTRANSFERASE WITHOUT A BOUND S-ADENOSYL METHIONINE
Descriptor:nonstructural protein NS5
Authors:Noble, C.G.
Deposit date:2014-09-02
Release date:2014-10-15
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
Antiviral Res., 111C, 2014
4R8S
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DENGUE SEROTYPE 3 METHYLTRANSFERASE BOUND TO SINEFUNGIN
Descriptor:nonstructural protein NS5, SINEFUNGIN
Authors:Noble, C.G.
Deposit date:2014-09-02
Release date:2014-10-15
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
Antiviral Res., 111C, 2014
4XZ8
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THE CRYSTAL STRUCTURE OF ERVE VIRUS NUCLEOPROTEIN
Descriptor:Nucleoprotein
Authors:Guo, Y., Wang, W., Liu, X., Wang, X., Wang, J., Huo, T., Liu, B.
Deposit date:2015-02-04
Release date:2015-09-02
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins.
J.Virol., 89, 2015
4XZA
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THE CRYSTAL STRUCTURE OF ERVE VIRUS NUCLEOPROTEIN
Descriptor:Nucleoprotein
Authors:Guo, Y., Wang, W., Liu, X., Wang, X., Wang, J., Huo, T., Liu, B.
Deposit date:2015-02-04
Release date:2015-09-02
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins.
J.Virol., 89, 2015
4XZC
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THE CRYSTAL STRUCTURE OF KUPE VIRUS NUCLEOPROTEIN
Descriptor:Nucleoprotein
Authors:Guo, Y., Wang, W., Liu, X., Wang, X., Wang, J., Huo, T., Liu, B.
Deposit date:2015-02-04
Release date:2015-09-02
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins.
J.Virol., 89, 2015
4XZE
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THE CRYSTAL STRUCTURE OF HAZARA VIRUS NUCLEOPROTEIN
Descriptor:Nucleoprotein
Authors:Guo, Y., Wang, W., Liu, X., Wang, X., Wang, J., Huo, T., Liu, B.
Deposit date:2015-02-04
Release date:2015-09-02
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins.
J.Virol., 89, 2015
4Y2W
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CRYSTAL STRUCTURE OF A THERMOSTABLE ALANINE RACEMASE FROM THERMOANAEROBACTER TENGCONGENSIS MB4
Descriptor:Alanine racemase 1, PHOSPHATE ION, ALANINE
Authors:Xu, X., Ju, J., Dong, H.
Deposit date:2015-02-10
Release date:2015-09-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of a Thermostable Alanine Racemase from Thermoanaerobacter tengcongensis MB4 Reveals the Role of Gln360 in Substrate Selection
Plos One, 10, 2015
5I3P
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 27
Descriptor:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide
Authors:Noble, C.G.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016