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5AGK
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (2S)-2-AMINO-5-(2-(METHYLSULFINYL)ACETIMIDAMIDO) PENTANOIC ACID
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2015-02-02
Release date:2015-04-29
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(Methylthio)Acetimidamido)Pentanoic Acid.
J.Am.Chem.Soc., 137, 2015
5AGL
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (S)-2-AMINO-5-(2-(METHYLSULFONYL)ACETIMIDAMIDO)PENTANOIC ACID
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2015-02-02
Release date:2015-04-29
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(Methylthio)Acetimidamido)Pentanoic Acid.
J.Am.Chem.Soc., 137, 2015
5AGM
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (S)-2-AMINO-5-(2-OXOACETIMIDAMIDO)PENTANOIC ACID
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2015-02-02
Release date:2015-04-29
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(Methylthio)Acetimidamido)Pentanoic Acid.
J.Am.Chem.Soc., 137, 2015
5AGN
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (S)-2-AMINO-5-(2-HYDROXYACETIMIDAMIDO)PENTANOIC ACID
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2015-02-02
Release date:2015-04-29
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(Methylthio)Acetimidamido)Pentanoic Acid.
J.Am.Chem.Soc., 137, 2015
5AGO
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (S)-2-AMINO-5-(2-MERCAPTOACETIMIDAMIDO)PENTANOIC ACID
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2015-02-02
Release date:2015-04-29
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(Methylthio)Acetimidamido)Pentanoic Acid.
J.Am.Chem.Soc., 137, 2015
5AGP
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (S)-2-AMINO-5-(2-MERCAPTOACETIMIDAMIDO)PENTANOIC ACID
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2015-02-02
Release date:2015-04-29
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(Methylthio)Acetimidamido)Pentanoic Acid.
J.Am.Chem.Soc., 137, 2015
5BK4
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CRYO-EM STRUCTURE OF MCM2-7 DOUBLE HEXAMER ON DSDNA
Descriptor:DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Li, H., Yuan, Z., Bai, L.
Deposit date:2017-09-12
Release date:2017-10-25
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5C13
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CRYSTAL STRUCTURE OF TAF3 PHD FINGER BOUND TO HISTONE H3C4ME3 PEPTIDE
Descriptor:Transcription initiation factor TFIID subunit 3, H3 peptide, ZINC ION
Authors:Li, H., Huang, J.
Deposit date:2015-06-12
Release date:2015-11-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Crystal Structure of Jarid1a PHD finger bound to histone H3C4me3 peptide
Nat Commun, 2015
5CP4
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CRYOGENIC STRUCTURE OF P450CAM
Descriptor:CYTOCHROME P450CAM, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:1998-05-28
Release date:1998-09-16
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect.
Biochemistry, 37, 1998
5FB0
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CRYSTAL STRUCTURE OF A PHD FINGER BOUND TO HISTONE H3 T3PH PEPTIDE
Descriptor:Nuclear autoantigen Sp-100, Peptide from Histone H3, ZINC ION
Authors:Li, H., Zhang, X.
Deposit date:2015-12-13
Release date:2016-05-04
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C
J.Biol.Chem., 291, 2016
5FB1
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CRYSTAL STRUCTURE OF A PHD FINGER BOUND TO HISTONE H3 K9ME3 PEPTIDE
Descriptor:Nuclear autoantigen Sp-100, Peptide from Histone H3, ZINC ION, ...
Authors:Li, H., Zhang, X.
Deposit date:2015-12-13
Release date:2016-05-04
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C
J.Biol.Chem., 291, 2016
5FJ2
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-((4-CHLORO-3-((METHYLAMINO)METHYL) PHENOXY)METHYL)QUINOLIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2015-10-06
Release date:2015-10-28
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.
J.Med.Chem., 58, 2015
5FJ3
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-((4-CHLORO-3-((METHYLAMINO)METHYL) PHENOXY)METHYL)QUINOLIN-2-AMINE IN THE ABSENCE OF ACETATE
Descriptor:NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2015-10-06
Release date:2015-10-28
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.
J.Med.Chem., 58, 2015
5UNR
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 3-[(2-AMINOQUINOLIN-7-YL)METHOXY]-5-((METHYLAMINO)METHYL)BENZONITRILE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017
5UNS
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-[(3-ETHYL-5-((METHYLAMINO)METHYL)PHENOXY)METHYL]QUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017
5UNT
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-7-[(3-((METHYLAMINO)METHYL)PHENOXY)METHYL]QUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017
5UNU
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 3-[(2-AMINO-4-METHYLQUINOLIN-7-YL)METHOXY]-5-((METHYLAMINO)METHYL)BENZONITRILE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017
5UNV
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-7-[3-((METHYLAMINO)METHYL)PHENETHYL]QUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017
5UNW
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 3-[2-(2-AMINO-4-METHYLQUINOLIN-7-YL)ETHYL]-5-((METHYLAMINO)METHYL)BENZONITRILE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.044 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017
5UNX
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 3-[(2-AMINO-4-METHYLQUINOLIN-7-YL)METHOXY]-5-(2-(METHYLAMINO)ETHYL)BENZONITRILE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017
5UNY
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (RS)-3-[(2-AMINO-4-METHYLQUINOLIN-7-YL)METHOXY]-5-(2-(METHYLAMINO)PROPYL)BENZONITRILE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017
5UNZ
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (R)-3-[(2-AMINO-4-METHYLQUINOLIN-7-YL)METHOXY]-5-(2-(METHYLAMINO)PROPYL)BENZONITRILE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017
5UO0
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (S)-3-[(2-AMINO-4-METHYLQUINOLIN-7-YL)METHOXY]-5-(2-(METHYLAMINO)PROPYL)BENZONITRILE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017
5UO1
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STRUCTURE OF HUMAN NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 3-[(2-AMINOQUINOLIN-7-YL)METHOXY]-5-((METHYLAMINO)METHYL)BENZONITRILE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017
5UO2
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STRUCTURE OF HUMAN NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 7-[(3-ETHYL-5-((METHYLAMINO)METHYL)PHENOXY)METHYL]QUINOLIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2017-01-31
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.947 Å)
Cite:Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
J. Med. Chem., 60, 2017