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8CDN
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BU of 8cdn by Molmil
Crystal structure of human Brachyury in complex with a single T box binding element DNA
Descriptor: DNA (5'-D(*AP*GP*GP*CP*TP*CP*AP*CP*AP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*TP*GP*TP*GP*AP*GP*CP*CP*T)-3'), T-box transcription factor T
Authors:Newman, J.A, Gavard, A.E, von Delft, F, Gileadi, O, Bountra, C.
Deposit date:2023-01-31
Release date:2023-03-22
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of human Brachyury in complex with a single T box binding element DNA
To Be Published
6F59
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BU of 6f59 by Molmil
Crystal structure of human Brachyury (T) G177D variant in complex with DNA
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Brachyury protein, DNA (26-MER), ...
Authors:Newman, J.A, Gavard, A.E, Krojer, T, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2017-12-01
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Crystal structure of human Brachyury (T) G177D variant in complex with DNA
To Be Published
6F58
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BU of 6f58 by Molmil
Crystal structure of human Brachyury (T) in complex with DNA
Descriptor: Brachyury protein, DNA (5'-D(*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP*AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*TP*T)-3'), SODIUM ION
Authors:Newman, J.A, Gavard, A.E, Krojer, T, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2017-12-01
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.253 Å)
Cite:Crystal structure of human Brachyury (T) in complex with DNA
To Be Published
4V0P
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BU of 4v0p by Molmil
Crystal structure of the MAGE homology domain of human MAGE-A3
Descriptor: MELANOMA-ASSOCIATED ANTIGEN 3
Authors:Newman, J.A, Aitkenhead, H, Cooper, C.D.O, Pinkas, D.M, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2014-09-17
Release date:2014-10-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.
Plos One, 11, 2016
4CVO
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BU of 4cvo by Molmil
Crystal structure of the N-terminal colied-coil domain of human DNA excision repair protein ERCC-6
Descriptor: DNA EXCISION REPAIR PROTEIN ERCC-6, MAGNESIUM ION
Authors:Newman, J.A, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2014-03-28
Release date:2014-04-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of the N-Terminal Colied-Coil Domain of Human DNA Excision Repair Protein Ercc-6
To be Published
6YHR
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BU of 6yhr by Molmil
Crystal structure of Werner syndrome helicase
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Werner syndrome ATP-dependent helicase, ZINC ION
Authors:Newman, J.A, Gavard, A.E, Savitsky, P, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2020-03-30
Release date:2020-04-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Life Sci Alliance, 4, 2021
6ZSL
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BU of 6zsl by Molmil
Crystal structure of the SARS-CoV-2 helicase at 1.94 Angstrom resolution
Descriptor: PHOSPHATE ION, SARS-CoV-2 helicase NSP13, ZINC ION
Authors:Newman, J.A, Yosaatmadja, Y, Douangamath, A, Arrowsmith, C.H, von Delft, F, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2020-07-15
Release date:2020-07-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.
Nat Commun, 12, 2021
6ZU8
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BU of 6zu8 by Molmil
Crystal structure of human Brachyury G177D variant in complex with Afatinib
Descriptor: Brachyury protein, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide, ZINC ION
Authors:Newman, J.A, Gavard, A.E, Shrestha, L, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2020-07-21
Release date:2020-08-05
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human Brachyury G177D variant in complex with Afatinib
To Be Published
7ZL2
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BU of 7zl2 by Molmil
Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-039-246-810
Descriptor: T-box transcription factor T, UNKNOWN LIGAND
Authors:Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O.
Deposit date:2022-04-13
Release date:2022-06-22
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-039-246-810
To Be Published
7ZKF
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BU of 7zkf by Molmil
Crystal Structure of human Brachyury G177D variant in complex with CF-5-86
Descriptor: PHOSPHATE ION, T-box transcription factor T, UNKNOWN LIGAND
Authors:Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O.
Deposit date:2022-04-12
Release date:2022-06-22
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Crystal Structure of human Brachyury G177D variant in complex with CF-5-86
To Be Published
7ZK2
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BU of 7zk2 by Molmil
Crystal Structure of human Brachyury G177D variant in complex with CSC027898502
Descriptor: N-[4-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenyl]ethanamide, PHOSPHATE ION, T-box transcription factor T
Authors:Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O.
Deposit date:2022-04-12
Release date:2022-06-22
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of human Brachyury G177D variant in complex with CSC027898502
To Be Published
8A7N
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BU of 8a7n by Molmil
Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125)
Descriptor: N-(3-azanylpropyl)-3-[[(3S)-1-(2-fluorophenyl)-2-oxidanylidene-pyrrolidin-3-yl]amino]-N-methyl-benzamide, PHOSPHATE ION, T-box transcription factor T
Authors:Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O.
Deposit date:2022-06-21
Release date:2022-10-05
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125)
To Be Published
8A10
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BU of 8a10 by Molmil
Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143
Descriptor: T-box transcription factor T, UNKNOWN LIGAND
Authors:Newman, J.A, Gavard, A, Aitkenhead, H, Imprachim, N, Sherestha, L, Burgess-Brown, N.A, von Delft, F, Bountra, C, Gileadi, O.
Deposit date:2022-05-30
Release date:2022-07-13
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal Structure of human Brachyury G177D variant in complex with Molpolrt-020-049-143
To Be Published
6SXW
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BU of 6sxw by Molmil
Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)
Descriptor: SULFATE ION, Zinc finger protein 638
Authors:Newman, J.A, Aitkenhead, H, Wang, D, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2019-09-26
Release date:2019-10-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Crystal structure of the first RRM domain of human Zinc finger protein 638 (ZNF638)
To Be Published
6GY4
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BU of 6gy4 by Molmil
Crystal structure of the N-terminal KH domain of human BICC1
Descriptor: 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL, CHLORIDE ION, Protein bicaudal C homolog 1, ...
Authors:Newman, J.A, Katis, V.L, Shrestha, L, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2018-06-28
Release date:2018-07-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.986 Å)
Cite:Crystal structure of the N-terminal KH domain of human BICC1
To Be Published
6HQ9
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BU of 6hq9 by Molmil
Crystal structure of the Tudor domain of human ERCC6-L2
Descriptor: DNA excision repair protein ERCC-6-like 2
Authors:Newman, J.A, Gavard, A.E, Nathan, W.J, Pinkas, D.M, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2018-09-24
Release date:2018-10-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.982 Å)
Cite:Crystal structure of the Tudor domain of human ERCC6-L2
To Be Published
5MR1
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BU of 5mr1 by Molmil
Crystal structure of the Pleckstrin homology domain of Interactor protein for cytohesin exchange factors 1 (IPCEF1)
Descriptor: Interactor protein for cytohesin exchange factors 1
Authors:Newman, J.A, Aitkenhead, H, Wang, D, Burgess-Brown, N, Williams, E, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2016-12-21
Release date:2017-01-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structure of the Pleckstrin homology domain of Interactor protein for cytohesin exchange factors 1 (IPCEF1)
To be published
4MHV
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BU of 4mhv by Molmil
Crystal structure of the PNT domain of human ETS2
Descriptor: ACETATE ION, CALCIUM ION, GLYCEROL, ...
Authors:Newman, J.A, Cooper, C.D.O, Krojer, T, Shrestha, L, Burgess-brown, N, Arrowsmith, C.H, Bountra, C, Edwards, A, Gileadi, O.
Deposit date:2013-08-30
Release date:2013-09-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of the PNT domain of human ETS2
To be Published
5OCN
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BU of 5ocn by Molmil
Crystal structure of the forkhead domain of human FOXN1
Descriptor: Forkhead box protein N1, POTASSIUM ION
Authors:Newman, J.A, Aitkenhead, H, Pinkas, D.M, von Delft, F, Arrowsmith, C.H, Edwwards, A, Bountra, C, Gileadi, O.
Deposit date:2017-07-03
Release date:2017-08-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the forkhead domain of human FOXN1
To be published
5NZX
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BU of 5nzx by Molmil
Crystal structure of DNA cross-link repair protein 1A in complex with Ceftriaxone (alternative site)
Descriptor: Ceftriaxone, DNA cross-link repair 1A protein, NICKEL (II) ION
Authors:Newman, J.A, Aitkenhead, H, Kupinska, K, Burgess-Brown, N.A, Talon, R, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2017-05-15
Release date:2017-06-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Crystal structure of DNA cross-link repair protein 1A in complex with Ceftriaxone (alternative site)
To Be Published
5NZW
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BU of 5nzw by Molmil
Crystal structure of DNA cross-link repair protein 1A in complex with ceftriaxone
Descriptor: Ceftriaxone, DNA cross-link repair 1A protein, NICKEL (II) ION
Authors:Newman, J.A, Aitkenhead, H, Kupinska, K, Burgess-Brown, N.A, Talon, R, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2017-05-15
Release date:2017-06-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of DNA cross-link repair protein 1A in complex with ceftriaxone
To Be Published
5NZY
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BU of 5nzy by Molmil
Crystal structure of DNA cross-link repair protein 1A in complex with Cefotaxime
Descriptor: (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid, DNA cross-link repair 1A protein, NICKEL (II) ION
Authors:Newman, J.A, Aitkenhead, H, Kupinska, K, Burgess-Brown, N.A, Talon, R, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2017-05-15
Release date:2017-06-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.551 Å)
Cite:Crystal structure of DNA cross-link repair protein 1A in complex with Cefotaxime
To Be Published
5LBA
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BU of 5lba by Molmil
Crystal structure of human RECQL5 helicase in complex with DSPL fragment(1-cyclohexyl-3-(oxolan-2-ylmethyl)urea, SGC - Diamond XChem I04-1 fragment screening.
Descriptor: 1-cyclohexyl-3-[[(2~{R})-oxolan-2-yl]methyl]urea, ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase Q5, ...
Authors:Newman, J.A, Aitkenhead, H, Talon, R, Savitsky, P, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O, Structural Genomics Consortium (SGC)
Deposit date:2016-06-15
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human RECQL5 helicase in complex with 3D fragment (1-cyclohexyl-3-(oxolan-2-ylmethyl)urea)
To be published
5A9J
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BU of 5a9j by Molmil
Crystal structure of the Helicase domain of human DNA polymerase theta, apo-form
Descriptor: DNA POLYMERASE THETA
Authors:Newman, J.A, Cooper, C.D.O, Aitkenhead, H, Pinkas, D.M, Kupinska, K, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2015-07-21
Release date:2015-12-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Structure, 23, 2015
5LB3
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BU of 5lb3 by Molmil
Crystal structure of human RECQL5 helicase in complex with ADP/Mg.
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase Q5, MAGNESIUM ION, ...
Authors:Newman, J.A, Aitkenhead, H, Savitsky, P, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Gileadi, O, Structural Genomics Consortium (SGC)
Deposit date:2016-06-15
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
Nucleic Acids Res., 45, 2017

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PDB entries from 2024-09-18

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