8A7N
Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125)
Summary for 8A7N
Entry DOI | 10.2210/pdb8a7n/pdb |
Descriptor | T-box transcription factor T, PHOSPHATE ION, N-(3-azanylpropyl)-3-[[(3S)-1-(2-fluorophenyl)-2-oxidanylidene-pyrrolidin-3-yl]amino]-N-methyl-benzamide, ... (4 entities in total) |
Functional Keywords | brachyury, chordoma, tbxt, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 20135.04 |
Authors | Newman, J.A.,Gavard, A.,Aitkenhead, H.,Imprachim, N.,Sherestha, L.,Burgess-Brown, N.A.,von Delft, F.,Bountra, C.,Gileadi, O. (deposition date: 2022-06-21, release date: 2022-10-05, Last modification date: 2024-01-31) |
Primary citation | Newman, J.A.,Gavard, A.,Aitkenhead, H.,Imprachim, N.,Sherestha, L.,Burgess-Brown, N.A.,von Delft, F.,Bountra, C.,Gileadi, O. Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125) To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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