8A7N
Crystal Structure of human Brachyury G177D variant in complex with (S)-N-(3-aminopropyl)-3-((1-(2-fluorophenyl)-2-oxopyrrolidin-3-yl)amino)-N-methylbenzamide (CF-2-125)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | T-box transcription factor T | polymer | 172 | 19655.6 | 1 | UniProt (O15178) Pfam (PF00907) | Homo sapiens (human) | Brachyury protein,Protein T |
| 2 | B (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 3 | C (A) | N-(3-azanylpropyl)-3-[[(3S)-1-(2-fluorophenyl)-2-oxidanylidene-pyrrolidin-3-yl]amino]-N-methyl-benzamide | non-polymer | 384.4 | 1 | Chemie (L9E) | |||
| 4 | D (A) | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A: 41 - 211 (UniProt: O15178)
| PDB | External Database | Details |
|---|---|---|
| Gly 40 | - | expression tag |
| Asp 177 | Gly 177 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19655.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 479.4 | |
| All* | Total formula weight | 20135.0 |
