Author results

2MV6
  • Download 2mv6
  • View 2mv6
Molmil generated image of 2mv6
SOLUTION STRUCTURE OF THE TRANSMEMBRANE DOMAIN AND THE JUXTA-MEMBRANE DOMAIN OF THE ERYTHROPOIETIN RECEPTOR IN MICELLES
Descriptor:Erythropoietin receptor
Authors:Li, Q., Wong, Y., Huang, Q., Kang, C.
Deposit date:2014-09-23
Release date:2014-12-10
Method:SOLUTION NMR
Cite:Structural insight into the transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles.
Biophys.J., 107, 2014
3PFT
  • Download 3pft
  • View 3pft
Molmil generated image of 3pft
CRYSTAL STRUCTURE OF UNTAGGED C54A MUTANT FLAVIN REDUCTASE (DSZD) IN COMPLEX WITH FMN FROM MYCOBACTERIUM GOODII
Descriptor:Flavin reductase, FLAVIN MONONUCLEOTIDE
Authors:Li, Q., Xu, P., Ma, C., Gu, L., Liu, X., Zhang, C., Li, N., Su, J., Li, B., Liu, S.
Deposit date:2010-10-29
Release date:2011-11-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:The flavin reductase DSZD from a desulfurizing mycobacterium goodii strain: systemic manipulation and investigation based on the crystal structure
To be Published
1X81
  • Download 1x81
  • View 1x81
Molmil generated image of 1x81
FARNESYL TRANSFERASE STRUCTURE OF JANSEN COMPOUND
Descriptor:Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
Authors:Li, Q., Claiborne, A., Li, T., Hasvold, L., Stoll, V.S., Muchmore, S., Jakob, C.G., Gu, W., Cohen, J., Hutchins, C., Frost, D., Rosenberg, S.H., Sham, H.L.
Deposit date:2004-08-16
Release date:2004-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Bioorg.Med.Chem.Lett., 14, 2004
2F7X
  • Download 2f7x
  • View 2f7x
Molmil generated image of 2f7x
PROTEIN KINASE A BOUND TO (S)-2-(1H-INDOL-3-YL)-1-[5-((E)-2-PYRIDIN-4-YL-VINYL)-PYRIDIN-3-YLOXYMETHYL]-ETHYLAMINE
Descriptor:cAMP-dependent protein kinase, alpha-catalytic subunit, PKI, ...
Authors:Li, Q., Li, T., Zhu, G.D., Gong, J., Claibone, A., Dalton, C., Luo, Y., Johnson, E.F., Shi, Y., Liu, X., Klinghofer, V., Bauch, J.L., Marsh, K.C., Bouska, J.J., Arries, S., De Jong, R., Oltersdorf, T., Stoll, V.S., Jakob, C.G., Rosenberg, S.H., Giranda, V.L.
Deposit date:2005-12-01
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.
Bioorg.Med.Chem.Lett., 16, 2006
2F7Z
  • Download 2f7z
  • View 2f7z
Molmil generated image of 2f7z
PROTEIN KINASE A BOUND TO (R)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
Descriptor:cAMP-dependent protein kinase, alpha-catalytic subunit, PKI, ...
Authors:Li, Q., Woods, K.W., Thomas, S., Zhu, G.D., Packard, G., Fisher, J., Li, T., Gong, J., Dinges, J., Song, X., Abrams, J., Luo, Y., Johnson, E.F., Shi, Y., Liu, X., Klinghofer, V., Des Jong, R., Oltersdorf, T., Stoll, V.S., Jakob, C.G., Rosenberg, S.H., Giranda, V.L.
Deposit date:2005-12-01
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Bioorg.Med.Chem.Lett., 16, 2006
4FVK
  • Download 4fvk
  • View 4fvk
Molmil generated image of 4fvk
STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF NEURAMINIDASE-LIKE MOLECULE N10 DERIVED FROM BAT INFLUENZA A VIRUS
Descriptor:Neuraminidase, CALCIUM ION, ZINC ION, ...
Authors:Li, Q., Sun, X.M., Li, Z.X., Liu, Y., Vavricka, C.J., Qi, J.X., Gao, G.F.
Deposit date:2012-06-29
Release date:2012-09-19
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus
Proc.Natl.Acad.Sci.USA, 109, 2012
4ZHS
  • Download 4zhs
  • View 4zhs
Molmil generated image of 4zhs
CRYSTAL STRUCTURE OF ASPARTATE SEMIALDEHYDE DEHYDROGENASE FROM TRICHOPHYTON RUBRUM
Descriptor:Aspartate Semialdehyde Dehydrogenase, SULFATE ION
Authors:Li, Q., Cui, S.
Deposit date:2015-04-27
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Structural Insights into the Tetrameric State of Aspartate-beta-semialdehyde Dehydrogenases from Fungal Species
Sci Rep, 6, 2016
4ZIC
  • Download 4zic
  • View 4zic
Molmil generated image of 4zic
CRYSTAL STRUCTURE OF ASPARTATE SEMIALDEHYDE DEHYDROGENASE WITH NADP FROM TRICHOPHYTON RUBRUM
Descriptor:Aspartate Semialdehyde Dehydrogenase, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Li, Q., Cui, S.
Deposit date:2015-04-28
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.553 Å)
Cite:Structural Insights into the Tetrameric State of Aspartate-beta-semialdehyde Dehydrogenases from Fungal Species
Sci Rep, 6, 2016
2MXB
  • Download 2mxb
  • View 2mxb
Molmil generated image of 2mxb
STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THE MOUSE ERYTHROPOIETIN RECEPTOR
Descriptor:Erythropoietin receptor
Authors:Li, Q., Wong, Y., Lee, M., Kang, C.
Deposit date:2014-12-19
Release date:2015-09-23
Method:SOLUTION NMR
Cite:Solution structure of the transmembrane domain of the mouse erythropoietin receptor in detergent micelles.
Sci Rep, 5, 2015
3NSS
  • Download 3nss
  • View 3nss
Molmil generated image of 3nss
THE 2009 PANDEMIC H1N1 NEURAMINIDASE N1 LACKS THE 150-CAVITY IN ITS ACTIVE SITES
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Li, Q., Qi, J.X., Zhang, W., Vavricka, C.J., Shi, Y., Gao, G.F.
Deposit date:2010-07-02
Release date:2010-09-22
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site
Nat.Struct.Mol.Biol., 17, 2010
4OE1
  • Download 4oe1
  • View 4oe1
Molmil generated image of 4oe1
CRYSTAL STRUCTURE OF THE PENTATRICOPEPTIDE REPEAT PROTEIN PPR10 (C256S/C430S/C449S) IN COMPLEX WITH AN 18-NT PSAJ RNA ELEMENT
Descriptor:Chloroplast pentatricopeptide repeat protein 10, psaJ RNA, PHOSPHATE ION
Authors:Li, Q., Yan, C., Wu, J., Yin, P., Yan, N.
Deposit date:2014-01-11
Release date:2014-09-24
Last modified:2015-02-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Examination of the dimerization states of the single-stranded RNA recognition protein pentatricopeptide repeat 10 (PPR10).
J.Biol.Chem., 289, 2014
4RFR
  • Download 4rfr
  • View 4rfr
Molmil generated image of 4rfr
COMPLEX STRUCTURE OF ALKB/RHEIN
Descriptor:Alpha-ketoglutarate-dependent dioxygenase AlkB, 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, MANGANESE (II) ION
Authors:Li, Q., Huang, Y., Li, J.F., Yang, C.-G.
Deposit date:2014-09-27
Release date:2016-04-06
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage.
J.Biol.Chem., 291, 2016
1OR5
  • Download 1or5
  • View 1or5
Molmil generated image of 1or5
SOLUTION STRUCTURE OF THE HOLO-FORM OF THE FRENOLICIN ACYL CARRIER PROTEIN, MINIMIZED MEAN STRUCTURE
Descriptor:acyl carrier protein
Authors:Li, Q., Khosla, C., Puglisi, J., Liu, C.W.
Deposit date:2003-03-11
Release date:2003-07-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure and Backbone Dynamics of the Holo Form of the Frenolicin Acyl Carrier Protein
Biochemistry, 42, 2003
1ZCM
  • Download 1zcm
  • View 1zcm
Molmil generated image of 1zcm
HUMAN CALPAIN PROTEASE CORE INHIBITED BY ZLLYCH2F
Descriptor:Calpain 1, large [catalytic] subunit, CALCIUM ION, ...
Authors:Li, Q., Hanzlik, R.P., Weaver, R.F., Schonbrunn, E.
Deposit date:2005-04-12
Release date:2006-01-31
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core
Biochemistry, 45, 2006
2I1J
  • Download 2i1j
  • View 2i1j
Molmil generated image of 2i1j
MOESIN FROM SPODOPTERA FRUGIPERDA AT 2.1 ANGSTROMS RESOLUTION
Descriptor:Moesin, CHLORIDE ION, UREA, ...
Authors:Li, Q., Nance, M.R., Tesmer, J.J.G.
Deposit date:2006-08-14
Release date:2006-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central alpha-Helical Domain.
J.Mol.Biol., 365, 2007
2MFR
  • Download 2mfr
  • View 2mfr
Molmil generated image of 2mfr
SOLUTION STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THE INSULIN RECEPTOR IN MICELLES
Descriptor:Insulin receptor
Authors:Li, Q., Wong, Y.L., Kang, C.
Deposit date:2013-10-20
Release date:2014-04-02
Method:SOLUTION NMR
Cite:Solution structure of the transmembrane domain of the insulin receptor in detergent micelles
Biochim.Biophys.Acta, 1838, 2014
2MHF
  • Download 2mhf
  • View 2mhf
Molmil generated image of 2mhf
SOLUTION STRUCTURE OF THE CYCLIC-NUCLEOTIDE BINDING HOMOLOGY DOMAIN OF A KCNH CHANNEL
Descriptor:Uncharacterized protein
Authors:Li, Q., Ng, H.
Deposit date:2013-11-21
Release date:2014-04-02
Method:SOLUTION NMR
Cite:Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel
J.Struct.Biol., 2014
4G7V
  • Download 4g7v
  • View 4g7v
Molmil generated image of 4g7v
CRYSTAL STRUCTURE OF VOLTAGE SENSING DOMAIN OF CI-VSP WITH FRAGMENT ANTIBODY (R217E, 2.5 A)
Descriptor:fragment antibody heavy chain, fragment antibody light chain, Voltage-sensor containing phosphatase, ...
Authors:Li, Q.
Deposit date:2012-07-20
Release date:2014-02-05
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.
Nat. Struct. Mol. Biol., 21, 2014
4G7Y
  • Download 4g7y
  • View 4g7y
Molmil generated image of 4g7y
CRYSTAL STRUCTURE OF VOLTAGE SENSING DOMAIN OF CI-VSP WITH FRAGMENT ANTIBODY (R217E, 2.8 A)
Descriptor:Fragment antibody heavy chain, Fragment antibody light chain, Voltage-sensor containing phosphatase, ...
Authors:Li, Q.
Deposit date:2012-07-20
Release date:2014-02-05
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.
Nat. Struct. Mol. Biol., 21, 2014
4G80
  • Download 4g80
  • View 4g80
Molmil generated image of 4g80
CRYSTAL STRUCTURE OF VOLTAGE SENSING DOMAIN OF CI-VSP WITH FRAGMENT ANTIBODY (WT, 3.8 A)
Descriptor:Voltage-sensor containing phosphatase, fragment antibody heavy chain, fragment antibody light chain
Authors:Li, Q.
Deposit date:2012-07-20
Release date:2014-02-05
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.
Nat. Struct. Mol. Biol., 21, 2014
4HZV
  • Download 4hzv
  • View 4hzv
Molmil generated image of 4hzv
THE CRYSTAL STRUCTURE OF INFLUENZA A NEURAMINIDASE N3
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
Deposit date:2012-11-15
Release date:2013-11-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.
J.Virol., 87, 2013
4HZW
  • Download 4hzw
  • View 4hzw
Molmil generated image of 4hzw
CRYSTAL STRUCTURE OF INFLUENZA A NEURAMINIDASE N3 COMPLEXED WITH LANINAMIVIR
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
Deposit date:2012-11-15
Release date:2013-11-06
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.
J.Virol., 87, 2013
4HZX
  • Download 4hzx
  • View 4hzx
Molmil generated image of 4hzx
CRYSTAL STRUCTURE OF INFLUENZA A NEURAMINIDASE N3 COMPLEXED WITH OSELTAMIVIR
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
Deposit date:2012-11-15
Release date:2013-11-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.
J.Virol., 87, 2013
4HZY
  • Download 4hzy
  • View 4hzy
Molmil generated image of 4hzy
CRYSTAL STRUCTURE OF INFLUENZA A NEURAMINIDASE N3-H274Y
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
Deposit date:2012-11-16
Release date:2013-11-06
Method:X-RAY DIFFRACTION (1.598 Å)
Cite:Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.
J.Virol., 87, 2013
4HZZ
  • Download 4hzz
  • View 4hzz
Molmil generated image of 4hzz
CRYSTAL STRUCTURE OF INFLUENZA NEURAMINIDASE N3-H274Y COMPLEXED WITH OSELTAMIVIR
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Li, Q., Qi, J., Vavricka, C.J., Gao, G.F.
Deposit date:2012-11-16
Release date:2013-11-06
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.
J.Virol., 87, 2013