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3LBF
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BU of 3lbf by Molmil
Crystal structure of Protein L-isoaspartyl methyltransferase from Escherichia coli
Descriptor: GLYCEROL, PHOSPHATE ION, Protein-L-isoaspartate O-methyltransferase, ...
Authors:Fang, P, Li, X, Wang, J, Niu, L, Teng, M.
Deposit date:2010-01-08
Release date:2010-09-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the protein L-isoaspartyl methyltransferase from Escherichia coli
Cell Biochem.Biophys., 58, 2010
3MNM
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BU of 3mnm by Molmil
Crystal structure of GAE domain of GGA2p from Saccharomyces cerevisiae
Descriptor: ADP-ribosylation factor-binding protein GGA2, GLYCEROL, SULFATE ION
Authors:Fang, P, Wang, J, Li, X, Niu, L, Teng, M.
Deposit date:2010-04-21
Release date:2010-09-08
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5
Biochemistry, 49, 2010
4YCU
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BU of 4ycu by Molmil
Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase
Descriptor: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, GLYCEROL, LYSINE, ...
Authors:Fang, P, Wang, J, Guo, M.
Deposit date:2015-02-20
Release date:2015-06-10
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.
Chem. Biol., 22, 2015
4YCV
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BU of 4ycv by Molmil
Crystal structure of cladosporin in complex with plasmodium lysyl-tRNA synthetase
Descriptor: Lysine--tRNA ligase, cladosporin
Authors:Fang, P, Wang, J, Guo, M.
Deposit date:2015-02-20
Release date:2015-06-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.406 Å)
Cite:Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.
Chem.Biol., 22, 2015
4YCW
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BU of 4ycw by Molmil
Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant
Descriptor: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, Lysine--tRNA ligase, ...
Authors:Fang, P, Wang, J, Guo, M.
Deposit date:2015-02-20
Release date:2015-06-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Specific Inhibition of tRNA Synthetase by ATP Competitive Inhibitor
Chem.Biol., 22, 2015
4P3O
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BU of 4p3o by Molmil
Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 2
Descriptor: (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, GLYCEROL, Threonine--tRNA ligase, ...
Authors:Fang, P, Yu, X, Chen, K, Chen, X, Guo, M.
Deposit date:2014-03-09
Release date:2015-03-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.505 Å)
Cite:Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
4P3P
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BU of 4p3p by Molmil
Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 3
Descriptor: (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, GLYCEROL, Threonine--tRNA ligase, ...
Authors:Fang, P, Yu, X, Chen, K, Chen, X, Guo, M.
Deposit date:2014-03-09
Release date:2015-03-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
4P3N
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BU of 4p3n by Molmil
Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 1
Descriptor: (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, Threonine--tRNA ligase, cytoplasmic, ...
Authors:Fang, P, Yu, X, Chen, K, Chen, X, Guo, M.
Deposit date:2014-03-09
Release date:2015-03-11
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
4TTV
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BU of 4ttv by Molmil
Crystal structure of human ThrRS complexing with a bioengineered macrolide BC194
Descriptor: (1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadec-6-en-2-yl]cyclobutanecarboxylic acid, Threonine--tRNA ligase, cytoplasmic, ...
Authors:Fang, P, Guo, M.
Deposit date:2014-06-23
Release date:2015-09-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor.
Sci Rep, 5, 2015
4DPG
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BU of 4dpg by Molmil
Crystal Structure of Human LysRS: P38/AIMP2 Complex I
Descriptor: ALANINE, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Fang, P, Wang, J, Bennett, S.P, Guo, M.
Deposit date:2012-02-13
Release date:2013-02-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.844 Å)
Cite:Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription.
Mol.Cell, 49, 2013
5YZX
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BU of 5yzx by Molmil
Crystal structure of E.coli LysU T146D mutant
Descriptor: BIS(ADENOSINE)-5'-TETRAPHOSPHATE, CALCIUM ION, Lysine--tRNA ligase, ...
Authors:Fang, P, Guo, M.
Deposit date:2017-12-16
Release date:2018-12-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A proposed role for MSC to reserve the canonical function in high eukaryotes prior to stimuli
To Be Published
6ILD
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BU of 6ild by Molmil
Crystal Structure of Human LysRS: P38/AIMP2 Complex II
Descriptor: 5'-O-[(S)-hydroxy(methyl)phosphoryl]adenosine, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, GLYCEROL, ...
Authors:Hei, Z, Liu, Z, Wang, J, Fang, P.
Deposit date:2018-10-17
Release date:2019-02-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.882 Å)
Cite:Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
J. Biol. Chem., 294, 2019
6ILH
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BU of 6ilh by Molmil
Crystal Structure of human lysyl-tRNA synthetase L350H mutant
Descriptor: 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Lysine-tRNA ligase
Authors:Hei, Z, Liu, Z, Wang, J, Fang, P.
Deposit date:2018-10-18
Release date:2019-02-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
J. Biol. Chem., 294, 2019
8K9X
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BU of 8k9x by Molmil
Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 5 (ADKI5)
Descriptor: (2~{S})-2,6-bis(azanyl)-~{N}-[3-[2-[[4-[(2,5-dimethoxyphenyl)amino]-1,3,5-triazin-2-yl]amino]phenyl]sulfonylpropyl]hexanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Lysine--tRNA ligase
Authors:Zhou, J, Xia, M, Yang, G, Li, P, Fang, P.
Deposit date:2023-08-01
Release date:2024-06-26
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors.
Commun Biol, 7, 2024
8K9V
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BU of 8k9v by Molmil
Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 3 (ADKI3)
Descriptor: GLYCEROL, LYSINE, Lysine--tRNA ligase, ...
Authors:Zhou, J, Xia, M, Yang, G, Li, P, Fang, P.
Deposit date:2023-08-01
Release date:2024-06-26
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors.
Commun Biol, 7, 2024
8K9S
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BU of 8k9s by Molmil
Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 1 (ADKI1)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LYSINE, Lysine--tRNA ligase, ...
Authors:Zhou, J, Xia, M, Yang, G, Li, P, Fang, P.
Deposit date:2023-08-01
Release date:2024-06-26
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors.
Commun Biol, 7, 2024
8K9W
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BU of 8k9w by Molmil
Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 4 (ADKI4)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Lysine--tRNA ligase, ~{N}2-(2-methoxyphenyl)-~{N}4-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine
Authors:Zhou, J, Xia, M, Yang, G, Li, P, Fang, P.
Deposit date:2023-08-01
Release date:2024-06-26
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors.
Commun Biol, 7, 2024
8K9U
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BU of 8k9u by Molmil
Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 2 (ADKI2)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LYSINE, Lysine--tRNA ligase, ...
Authors:Zhou, J, Xia, M, Yang, G, Li, P, Fang, P.
Deposit date:2023-08-01
Release date:2024-06-26
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors.
Commun Biol, 7, 2024
2EXU
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BU of 2exu by Molmil
Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ETHANOL, Transcription initiation protein SPT4/SPT5, ...
Authors:Xu, F, Guo, M, Fang, P, Teng, M, Niu, L.
Deposit date:2005-11-08
Release date:2006-11-08
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain
To be published
7EOD
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BU of 7eod by Molmil
MITF HLHLZ Delta AKE
Descriptor: GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor
Authors:Li, P, Liu, Z, Fang, P, Wang, J.
Deposit date:2021-04-22
Release date:2022-04-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.
Cell Res., 33, 2023
4EQG
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BU of 4eqg by Molmil
Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with Ala-AMS
Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Histidine triad nucleotide-binding protein 1
Authors:Wang, J, Fang, P, Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
7F09
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BU of 7f09 by Molmil
Crystal structure of the HLH-Lz domain of human TFE3
Descriptor: 1,2-ETHANEDIOL, Transcription factor E3, ZINC ION
Authors:Yang, G, Li, P, Liu, Z, Wu, S, Zhuang, C, Qiao, H, Fang, P, Wang, J.
Deposit date:2021-06-03
Release date:2021-07-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the dimerization mechanism of human transcription factor E3.
Biochem.Biophys.Res.Commun., 569, 2021
7F6W
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BU of 7f6w by Molmil
Crystal structure of Saccharomyces cerevisiae lysyl-tRNA Synthetase
Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Lysine--tRNA ligase
Authors:Wu, S, Li, P, Hei, Z, Zheng, L, Wang, J, Fang, P.
Deposit date:2021-06-26
Release date:2022-02-16
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.607 Å)
Cite:Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex.
Cell.Mol.Life Sci., 79, 2022
4EQH
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BU of 4eqh by Molmil
Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with Trp-AMS
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(L-TRYPTOPHYLAMINO)SULFONYL]ADENOSINE, Histidine triad nucleotide-binding protein 1
Authors:Wang, J, Fang, P, Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.668 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
4EQE
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BU of 4eqe by Molmil
Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with Lys-AMS
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Histidine triad nucleotide-binding protein 1
Authors:Wang, J, Fang, P, Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012

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