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1J56
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BU of 1j56 by Molmil
MINIMIZED AVERAGE STRUCTURE OF BERYLLOFLUORIDE-ACTIVATED NTRC RECEIVER DOMAIN: MODEL STRUCTURE INCORPORATING ACTIVE SITE CONTACTS
Descriptor: BERYLLIUM TRIFLUORIDE ION, NITROGEN REGULATION PROTEIN NR(I)
Authors:Hastings, C.A, Lee, S.-Y, Cho, H.S, Yan, D, Kustu, S, Wemmer, D.E.
Deposit date:2002-01-10
Release date:2003-08-19
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:High-Resolution Solution Structure of the Beryllofluoride-Activated NtrC Receiver Domain
Biochemistry, 42, 2003
1KRX
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BU of 1krx by Molmil
SOLUTION STRUCTURE OF BERYLLOFLUORIDE-ACTIVATED NTRC RECEIVER DOMAIN: MODEL STRUCTURES INCORPORATING ACTIVE SITE CONTACTS
Descriptor: BERYLLIUM TRIFLUORIDE ION, NITROGEN REGULATION PROTEIN NR(I)
Authors:Hastings, C.A, Lee, S.-Y, Cho, H.S, Yan, D, Kustu, S, Wemmer, D.E.
Deposit date:2002-01-10
Release date:2003-08-19
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:High-Resolution Solution Structure of the Beryllofluoride-Activated NtrC Receiver Domain
Biochemistry, 42, 2003
1KRW
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BU of 1krw by Molmil
SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF BERYLLOFLUORIDE-ACTIVATED NTRC RECEIVER DOMAIN
Descriptor: NITROGEN REGULATION PROTEIN NR(I)
Authors:Hastings, C.A, Lee, S.-Y, Cho, H.S, Yan, D, Kustu, S, Wemmer, D.E.
Deposit date:2002-01-10
Release date:2003-08-19
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:High-Resolution Solution Structure of the Beryllofluoride-Activated NtrC Receiver Domain
Biochemistry, 42, 2003
1LLS
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BU of 1lls by Molmil
CRYSTAL STRUCTURE OF UNLIGANDED MALTOSE BINDING PROTEIN WITH XENON
Descriptor: Maltose-binding periplasmic protein, XENON
Authors:Rubin, S.M, Lee, S.-Y, Ruiz, E.J, Pines, A, Wemmer, D.E.
Deposit date:2002-04-30
Release date:2002-09-18
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DETECTION AND CHARACTERIZATION OF XENON-BINDING SITES IN PROTEINS BY 129XE NMR SPECTROSCOPY
J.MOL.BIOL., 322, 2002
1MNL
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BU of 1mnl by Molmil
HIGH-RESOLUTION SOLUTION STRUCTURE OF A SWEET PROTEIN SINGLE-CHAIN MONELLIN (SCM) DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND DYNAMICAL SIMULATED ANNEALING CALCULATIONS, 21 STRUCTURES
Descriptor: MONELLIN
Authors:Lee, S.-Y, Lee, J.-H, Chang, H.-J, Jo, J.-M, Jung, J.-W, Lee, W.
Deposit date:1998-08-06
Release date:1999-06-08
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of a sweet protein single-chain monellin determined by nuclear magnetic resonance and dynamical simulated annealing calculations.
Biochemistry, 38, 1999
9B6H
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BU of 9b6h by Molmil
Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 and the cooling agonist C3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ...
Authors:Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y.
Deposit date:2024-03-25
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
6PKW
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BU of 6pkw by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry)
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6PKV
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BU of 6pkv by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6PQP
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BU of 6pqp by Molmil
Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzylthioformamide, ...
Authors:Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y.
Deposit date:2019-07-09
Release date:2020-01-08
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Neuron, 105, 2020
6PKX
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BU of 6pkx by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6PQQ
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BU of 6pqq by Molmil
Cryo-EM structure of human TRPA1 C621S mutant in the apo state
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily A member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
Authors:Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y.
Deposit date:2019-07-09
Release date:2020-01-08
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Neuron, 105, 2020
6PQO
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BU of 6pqo by Molmil
Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide, ...
Authors:Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y.
Deposit date:2019-07-09
Release date:2020-01-08
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Neuron, 105, 2020
5U9W
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BU of 5u9w by Molmil
Structure of CNTnw N149L in the intermediate 3 state
Descriptor: 2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}-2-octyldecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Nucleoside permease
Authors:Hirschi, M, Johnson, Z.L, Lee, S.-Y.
Deposit date:2016-12-18
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.555 Å)
Cite:Visualizing multistep elevator-like transitions of a nucleoside transporter.
Nature, 545, 2017
7TX7
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BU of 7tx7 by Molmil
Cryo-EM structure of the human reduced folate carrier
Descriptor: Digitonin, Reduced folate transporter,Soluble cytochrome b562
Authors:Wright, N.J, Fedor, J.G, Lee, S.-Y.
Deposit date:2022-02-07
Release date:2022-09-21
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Methotrexate recognition by the human reduced folate carrier SLC19A1.
Nature, 609, 2022
7TX6
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BU of 7tx6 by Molmil
Cryo-EM structure of the human reduced folate carrier in complex with methotrexate
Descriptor: Digitonin, METHOTREXATE, Reduced folate transporter,Soluble cytochrome b562
Authors:Wright, N.J, Fedor, J.G, Lee, S.-Y.
Deposit date:2022-02-07
Release date:2022-09-21
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Methotrexate recognition by the human reduced folate carrier SLC19A1.
Nature, 609, 2022
7RQZ
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BU of 7rqz by Molmil
Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ...
Authors:Kwon, D.H, Suo, Y, Lee, S.-Y.
Deposit date:2021-08-08
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
7RQU
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BU of 7rqu by Molmil
Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in a closed state, class I
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, SODIUM ION, ...
Authors:Kwon, D.H, Suo, Y, Lee, S.-Y.
Deposit date:2021-08-08
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
7RQY
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BU of 7rqy by Molmil
Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an open state, class B
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ...
Authors:Kwon, D.H, Suo, Y, Lee, S.-Y.
Deposit date:2021-08-08
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
7RQW
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BU of 7rqw by Molmil
Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an open state, class III
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ...
Authors:Kwon, D.H, Suo, Y, Lee, S.-Y.
Deposit date:2021-08-08
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
7RQX
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BU of 7rqx by Molmil
Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an intermediate-open state, class A
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ...
Authors:Kwon, D.H, Suo, Y, Lee, S.-Y.
Deposit date:2021-08-08
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
7RQV
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BU of 7rqv by Molmil
Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an intermediate-closed state, class II
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ...
Authors:Kwon, D.H, Suo, Y, Lee, S.-Y.
Deposit date:2021-08-08
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
5T77
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BU of 5t77 by Molmil
Crystal structure of the MOP flippase MurJ
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, ...
Authors:Kuk, A.C.Y, Lee, S.-Y.
Deposit date:2016-09-02
Release date:2016-12-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the MOP flippase MurJ in an inward-facing conformation.
Nat. Struct. Mol. Biol., 24, 2017
9B6D
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BU of 9b6d by Molmil
Cryo-EM structure of the mouse TRPM8 channel in the ligand-free desensitized state
Descriptor: CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y.
Deposit date:2024-03-25
Release date:2024-08-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
9B70
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BU of 9b70 by Molmil
Cryo-EM structure of MraY in complex with analogue 2
Descriptor: (2~{S},3~{S})-3-[(2~{S},3~{R},4~{S},5~{R})-5-(aminomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]oxy-2-[[3-[[[(2~{S})-6-azanyl-2-(hexadecanoylamino)hexanoyl]amino]methyl]phenyl]methylamino]-3-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]propanoic acid, MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase
Authors:Hao, A, Lee, S.-Y.
Deposit date:2024-03-26
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target.
Nat Commun, 15, 2024
9B71
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BU of 9b71 by Molmil
Cryo-EM structure of MraY in complex with analogue 3
Descriptor: (2~{S},3~{S})-3-[(2~{S},3~{R},4~{S},5~{R})-5-(aminomethyl)-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-[(2~{S},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]-2-[[4-[[[(2~{S})-5-carbamimidamido-2-(hexadecanoylamino)pentanoyl]amino]methyl]phenyl]methylamino]propanoic acid, MraYAA Nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase
Authors:Hao, A, Lee, S.-Y.
Deposit date:2024-03-26
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Development of a natural product optimization strategy for inhibitors against MraY, a promising antibacterial target.
Nat Commun, 15, 2024

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PDB entries from 2024-09-18

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