PDB: 153 件ウェブページステータス検索Chemie searchBIRD

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3WXG	Crystal structure of CYLD USP domain (C596A) in complex with Lys63-linked diubiquitin 分子名称: Ubiquitin, Uncharacterized protein 著者 Sato, Y, Fukai, S. 登録日 2014-07-30 公開日 2015-02-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity. Nat.Struct.Mol.Biol., 22, 2015
3V6C	Crystal Structure of USP2 in complex with mutated ubiquitin 分子名称: CHLORIDE ION, GLYCEROL, Ubiquitin, ... 著者 Neculai, M, Ernst, A, Sidhu, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2011-12-19 公開日 2012-12-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of USP2 in complex with mutated ubiquitin To be Published
3WXF	Crystal structure of CYLD USP domain (C596S E674Q) in complex with Met1-linked diubiquitin 分子名称: SULFATE ION, Ubiquitin, Uncharacterized protein 著者 Sato, Y, Fukai, S. 登録日 2014-07-30 公開日 2015-02-11 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity. Nat.Struct.Mol.Biol., 22, 2015
3V6E	Crystal Structure of USP2 and a mutant form of Ubiquitin 分子名称: CHLORIDE ION, GLYCEROL, Ubiquitin, ... 著者 Neculai, M, Ernst, A, Sidhu, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2011-12-19 公開日 2012-12-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A strategy for modulation of enzymes in the ubiquitin system. Science, 339, 2013
5A5B	Structure of the 26S proteasome-Ubp6 complex 分子名称: 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG, 26S PROTEASE REGULATORY SUBUNIT 6A, 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG, ... 著者 Aufderheide, A, Beck, F, Stengel, F, Hartwig, M, Schweitzer, A, Pfeifer, G, Goldberg, A.L, Sakata, E, Baumeister, W, Foerster, F. 登録日 2015-06-17 公開日 2015-07-22 最終更新日 2017-08-30 実験手法 ELECTRON MICROSCOPY (9.5 Å) 主引用文献 Structural Characterization of the Interaction of Ubp6 with the 26S Proteasome. Proc.Natl.Acad.Sci.USA, 112, 2015
3NHE	High Resolution Structure (1.26A) of USP2a in Complex with Ubiquitin 分子名称: Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 2, ZINC ION 著者 Schormann, N, DeLucas, L.J, Powell McCombs, D. 登録日 2010-06-14 公開日 2010-06-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 High resolution structure of USP2a in complex with ubiquitin To be Published
3MHS	Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module bound to ubiquitin aldehyde 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Protein SUS1, ... 著者 Samara, N.L, Datta, A.B, Berndsen, C.E, Zhang, X, Yao, T, Cohen, R.E, Wolberger, C. 登録日 2010-04-08 公開日 2010-04-21 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Structural insights into the assembly and function of the SAGA deubiquitinating module. Science, 328, 2010
5CHV	Crystal structure of USP18-ISG15 complex 分子名称: CHLORIDE ION, SULFATE ION, Ubiquitin-like protein ISG15, ... 著者 Fritz, G, Basters, A. 登録日 2015-07-10 公開日 2016-09-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.005 Å) 主引用文献 Structural basis of the specificity of USP18 toward ISG15. Nat. Struct. Mol. Biol., 24, 2017
4ZUX	SAGA DUB module Ubp8/Sgf11/Sus1/Sgf73 bound to ubiqitinated nucleosome 分子名称: DNA (145-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Morgan, M, Wolberger, C. 登録日 2015-05-17 公開日 2016-02-24 最終更新日 2016-03-09 実験手法 X-RAY DIFFRACTION (3.82 Å) 主引用文献 Structural basis for histone H2B deubiquitination by the SAGA DUB module. Science, 351, 2016
5JTJ	USP7CD-CTP in complex with Ubiquitin 分子名称: CALCIUM ION, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 7,Ubiquitin carboxyl-terminal hydrolase 7 著者 Murray, J.M, Rouge, L. 登録日 2016-05-09 公開日 2016-08-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.321 Å) 主引用文献 Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation. Structure, 24, 2016
5JTV	USP7CD-UBL45 in complex with Ubiquitin 分子名称: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 7 著者 Murray, J.M, Rouge, L. 登録日 2016-05-09 公開日 2016-10-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.312 Å) 主引用文献 Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation. Structure, 24, 2016
5K1A	Crystal structure of the UAF1-USP12 complex in C2 space group 分子名称: Ubiquitin carboxyl-terminal hydrolase 12, WD repeat-containing protein 48, ZINC ION 著者 Li, H, D'Andrea, A.D, Zheng, N. 登録日 2016-05-18 公開日 2016-07-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20. Mol.Cell, 63, 2016
3MTN	Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor 分子名称: CHLORIDE ION, GLYCEROL, UBIQUITIN VARIANT UBV.21.4, ... 著者 Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2010-04-30 公開日 2010-06-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A strategy for modulation of enzymes in the ubiquitin system. Science, 339, 2013
5K1C	Crystal structure of the UAF1/WDR20/USP12 complex 分子名称: PHOSPHATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE, Ubiquitin carboxyl-terminal hydrolase 12, ... 著者 Li, H, D'Andrea, A.D, Zheng, N. 登録日 2016-05-18 公開日 2016-07-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20. Mol.Cell, 63, 2016
3N3K	The catalytic domain of USP8 in complex with a USP8 specific inhibitor 分子名称: Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 8, ZINC ION 著者 Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Allali-Hassani, A, Lam, R, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium, Structural Genomics Consortium (SGC) 登録日 2010-05-20 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 A strategy for modulation of enzymes in the ubiquitin system. Science, 339, 2013
5CVM	USP46~ubiquitin BEA covalent complex 分子名称: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, ZINC ION 著者 Harris, S.F, Yin, J. 登録日 2015-07-27 公開日 2015-10-07 最終更新日 2015-11-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure, 23, 2015
5CVO	WDR48:USP46~ubiquitin ternary complex 分子名称: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ... 著者 Harris, S.F, Yin, J. 登録日 2015-07-27 公開日 2015-10-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.885 Å) 主引用文献 Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure, 23, 2015
5XU8	Crystal structure of human USP2 in complex with ubiquitin and 6-thioguanine 分子名称: 2-amino-1,9-dihydro-6H-purine-6-thione, CHLORIDE ION, SODIUM ION, ... 著者 Chou, C.Y, Chuang, S.J. 登録日 2017-06-22 公開日 2018-02-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2 Sci Rep, 8, 2018
5OHN	Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (low resolution) 分子名称: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION 著者 Gersch, M, Komander, D. 登録日 2017-07-17 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Mechanism and regulation of the Lys6-selective deubiquitinase USP30. Nat. Struct. Mol. Biol., 24, 2017
5OHP	Crystal structure of USP30 (C77A) in complex with Lys6-linked diubiquitin 分子名称: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION 著者 Gersch, M, Komander, D. 登録日 2017-07-17 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mechanism and regulation of the Lys6-selective deubiquitinase USP30. Nat. Struct. Mol. Biol., 24, 2017
5OHK	Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution) 分子名称: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION, ... 著者 Gersch, M, Komander, D. 登録日 2017-07-17 公開日 2017-09-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Mechanism and regulation of the Lys6-selective deubiquitinase USP30. Nat. Struct. Mol. Biol., 24, 2017
5XVE	Crystal structure of human USP2 C276S mutant in complex with ubiquitin 分子名称: Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin-40S ribosomal protein S27a, ZINC ION 著者 Chou, C.Y, Tang, H.C. 登録日 2017-06-27 公開日 2018-02-28 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2 Sci Rep, 8, 2018
6T9L	SAGA DUB module bound to a ubiqitinated nucleosome 分子名称: Histone H2A, Histone H2B, Histone H2B 1.1, ... 著者 Wang, H, Cramer, P. 登録日 2019-10-28 公開日 2020-01-29 最終更新日 2020-02-19 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure of the transcription coactivator SAGA. Nature, 577, 2020
6TBM	Structure of SAGA bound to TBP, including Spt8 and DUB 分子名称: Polyubiquitin-B, SAGA-associated factor 11, Spt20, ... 著者 Papai, G, Frechard, A, Kolesnikova, O, Crucifix, C, Schultz, P, Ben-Shem, A. 登録日 2019-11-01 公開日 2020-02-12 最終更新日 2021-06-30 実験手法 ELECTRON MICROSCOPY (20 Å) 主引用文献 Structure of SAGA and mechanism of TBP deposition on gene promoters. Nature, 577, 2020
7ZH4	USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement) 分子名称: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin-60S ribosomal protein L40, ... 著者 Rennie, M.L, Walden, H. 登録日 2022-04-05 公開日 2022-10-12 実験手法 ELECTRON MICROSCOPY (2.49 Å) 主引用文献 Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Sci Adv, 8, 2022

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