3V6E

Crystal Structure of USP2 and a mutant form of Ubiquitin

Summary for 3V6E

• Entry DOI: 10.2210/pdb3v6e/pdb
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin, ZINC ION, ... (6 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, ubiquitin, protease, hydrolase-signaling protein complex, hydrolase/signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm . Isoform 4: Nucleus : O75604; Ubiquitin: Cytoplasm : P0CG48
• Total number of polymer chains: 2
• Total formula weight: 52743.88

Authors

Neculai, M.,Ernst, A.,Sidhu, S.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2011-12-19, release date: 2012-12-19, Last modification date: 2023-09-13)

• Primary citation: Ernst, A.,Avvakumov, G.,Tong, J.,Fan, Y.,Zhao, Y.,Alberts, P.,Persaud, A.,Walker, J.R.,Neculai, A.M.,Neculai, D.,Vorobyov, A.,Garg, P.,Beatty, L.,Chan, P.K.,Juang, Y.C.,Landry, M.C.,Yeh, C.,Zeqiraj, E.,Karamboulas, K.,Allali-Hassani, A.,Vedadi, M.,Tyers, M.,Moffat, J.,Sicheri, F.,Pelletier, L.,Durocher, D.,Raught, B.,Rotin, D.,Yang, J.,Moran, M.F.,Dhe-Paganon, S.,Sidhu, S.S.; A strategy for modulation of enzymes in the ubiquitin system.; Science, 339:590-595, 2013; PubMed: 23287719; DOI: 10.1126/science.1230161

Experimental method

X-RAY DIFFRACTION (2.1 Å)