5XU8

Crystal structure of human USP2 in complex with ubiquitin and 6-thioguanine

Summary for 5XU8

Entry DOI	10.2210/pdb5xu8/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase 2, Ubiquitin-40S ribosomal protein S27a, 2-amino-1,9-dihydro-6H-purine-6-thione, ... (7 entities in total)
Functional Keywords	ternary complex, esi complex, hydrolase
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm . Isoform 4: Nucleus : O75604 Ubiquitin: Cytoplasm : P62992
Total number of polymer chains	2
Total formula weight	50311.30
Authors	Chou, C.Y.,Chuang, S.J. (deposition date: 2017-06-22, release date: 2018-02-28, Last modification date: 2023-11-22)
Primary citation	Chuang, S.J.,Cheng, S.C.,Tang, H.C.,Sun, C.Y.,Chou, C.Y. 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2 Sci Rep, 8:3102-3102, 2018 Cited by PubMed: 29449607 DOI: 10.1038/s41598-018-21476-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation