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1PIP	CRYSTAL STRUCTURE OF PAPAIN-SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE COMPLEX AT 1.7 ANGSTROMS RESOLUTION: NONCOVALENT BINDING MODE OF A COMMON SEQUENCE OF ENDOGENOUS THIOL PROTEASE INHIBITORS Descriptor: Papain, SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE Authors: Yamamoto, A, Tomoo, K, Doi, M, Ohishi, H, Inoue, M, Ishida, T, Yamamoto, D, Tsuboi, S, Okamoto, H, Okada, Y. Deposit date: 1992-10-03 Release date: 1993-10-31 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of papain-succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide complex at 1.7-A resolution: noncovalent binding mode of a common sequence of endogenous thiol protease inhibitors. Biochemistry, 31, 1992
1PE6	REFINED X-RAY STRUCTURE OF PAPAIN(DOT)E-64-C COMPLEX AT 2.1-ANGSTROMS RESOLUTION Descriptor: METHANOL, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE, PAPAIN Authors: Yamamoto, D, Matsumoto, K, Ohishi, H, Ishida, T, Inoue, M, Kitamura, K, Mizuno, H. Deposit date: 1991-05-14 Release date: 1993-04-15 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution. J.Biol.Chem., 266, 1991
1PPO	DETERMINATION OF THE STRUCTURE OF PAPAYA PROTEASE OMEGA Descriptor: MERCURY (II) ION, PROTEASE OMEGA Authors: Pickersgill, R.W, Rizkallah, P.J, Harris, G.W, Goodenough, P.W. Deposit date: 1991-07-12 Release date: 1993-10-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Determination of the Structure of Papaya Protease Omega Acta Crystallogr.,Sect.B, 47, 1991
1PPP	CRYSTAL STRUCTURE OF PAPAIN-E64-C COMPLEX. BINDING DIVERSITY OF E64-C TO PAPAIN S2 AND S3 SUBSITES Descriptor: METHANOL, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE, PAPAIN Authors: Ishida, T. Deposit date: 1993-03-17 Release date: 1994-01-31 Last modified: 2012-05-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsites. Biochem.J., 287, 1992
1POP	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX Descriptor: LEUPEPTIN, METHANOL, PAPAIN Authors: Schroder, E, Crawford, C. Deposit date: 1993-06-24 Release date: 1993-10-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: X-ray crystallographic structure of a papain-leupeptin complex. FEBS Lett., 315, 1993
1PPN	STRUCTURE OF MONOCLINIC PAPAIN AT 1.60 ANGSTROMS RESOLUTION Descriptor: METHANOL, PAPAIN, UNKNOWN LIGAND Authors: Pickersgill, R.W, Harris, G.W, Garman, E. Deposit date: 1991-10-25 Release date: 1994-01-31 Last modified: 2015-04-08 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure of Monoclinic Papain at 1.60 Angstroms Resolution Acta Crystallogr.,Sect.B, 48, 1992
1PPD	RESTRAINED LEAST-SQUARES REFINEMENT OF THE SULFHYDRYL PROTEASE PAPAIN TO 2.0 ANGSTROMS Descriptor: 2-HYDROXYETHYL-THIOPAPAIN, BETA-MERCAPTOETHANOL Authors: Jansonius, J.N. Deposit date: 1984-11-06 Release date: 1985-01-02 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Restrained Least-Squares Refinement of the Sulfhydryl Protease Papain to 2.0 Angstroms Acta Crystallogr.,Sect.A, 40, 1984
1Q6K	Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate Descriptor: Cathepsin K, SULFATE ION, TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE Authors: Catalano, J.G, Deaton, D.N, Furfine, E.S, Hassell, A.M, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M, Willard, D.H, Wright, L.L. Deposit date: 2003-08-13 Release date: 2004-03-16 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Exploration of the P1 SAR of aldehyde cathepsin K inhibitors Bioorg.Med.Chem.Lett., 14, 2004
1QDQ	X-RAY CRYSTAL STRUCTURE OF BOVINE CATHEPSIN B-CA074 COMPLEX Descriptor: CATHEPSIN B, [PROPYLAMINO-3-HYDROXY-BUTAN-1,4-DIONYL]-ISOLEUCYL-PROLINE Authors: Yamamoto, A. Deposit date: 1999-07-10 Release date: 2000-07-10 Last modified: 2018-01-31 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex. J.Biochem.(Tokyo), 127, 2000
1S4V	The 2.0 A crystal structure of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm Descriptor: DVA-LEU-LYS-0QE peptide, SULFATE ION, cysteine endopeptidase Authors: Than, M.E, Helm, M, Simpson, D.J, Lottspeich, F, Huber, R, Gietl, C. Deposit date: 2004-01-19 Release date: 2004-03-16 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2 Å) Cite: The 2.0 A crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm. J.Mol.Biol., 336, 2004
1SNK	Cathepsin K complexed with carbamate derivatized norleucine aldehyde Descriptor: Cathepsin K, N2-({[(4-BROMOPHENYL)METHYL]OXY}CARBONYL)-N1-[(1S)-1-FORMYLPENTYL]-L-LEUCINAMIDE, SULFATE ION Authors: Boros, E.E, Deaton, D.N, Hassell, A.M, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M, Thompson, J.B, Willard Jr, D.H, Wright, L.L. Deposit date: 2004-03-11 Release date: 2004-06-22 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Exploration of the P(2)-P(3) SAR of aldehyde cathepsin K inhibitors Bioorg.Med.Chem.Lett., 14, 2004
1SP4	Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed epoxysuccinyl inhibitor extends along the whole active site cleft Descriptor: Cathepsin B, methyl N-[(2S)-4-{[(1S)-1-{[(2S)-2-carboxypyrrolidin-1-yl]carbonyl}-3-methylbutyl]amino}-2-hydroxy-4-oxobutanoyl]-L-leucylglycylglycinate Authors: Stern, I, Schaschke, N, Moroder, L, Turk, D. Deposit date: 2004-03-16 Release date: 2004-05-04 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. Biochem.J., 381, 2004
1THE	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN Descriptor: Cathepsin B, amino{[(4S)-4-{[(benzyloxy)carbonyl]amino}-5-{[(2S)-1-(benzyloxy)-4-chloro-3-oxobutan-2-yl]amino}-5-oxopentyl]amino}methaniminium Authors: Huber, C.P, Jia, Z. Deposit date: 1995-09-15 Release date: 1996-03-10 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J.Biol.Chem., 270, 1995
1IWD	Proposed Amino Acid Sequence and the 1.63 Angstrom X-ray Crystal Structure of a Plant Cysteine Protease Ervatamin B: Insight into the Structural Basis of its Stability and Substrate Specificity. Descriptor: ERVATAMIN B, THIOSULFATE Authors: Chakrabarti, C, Biswas, S, Dattagupta, J.K. Deposit date: 2002-05-02 Release date: 2003-05-06 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Proposed amino acid sequence and the 1.63 A X-ray crystal structure of a plant cysteine protease, ervatamin B: Some insights into the structural basis of its stability and substrate specificity Proteins, 51, 2003
1ITO	Crystal Structure Analysis of Bovine Spleen Cathepsin B-E64c complex Descriptor: Cathepsin B, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE Authors: Yamamoto, A, Tomoo, T, Matsugi, K, Hara, T, In, Y, Murata, M, Kitamura, K, Ishida, T. Deposit date: 2002-01-19 Release date: 2003-01-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.286 Å) Cite: Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B-E64c complex BIOCHIM.BIOPHYS.ACTA, 1597, 2002
1KHQ	ORTHORHOMBIC FORM OF PAPAIN/ZLFG-DAM COVALENT COMPLEX Descriptor: Papain, peptidic inhibitor Authors: Janowski, R, Kozak, M, Jankowska, E, Grzonka, Z, Jaskolski, M. Deposit date: 2001-11-30 Release date: 2003-09-09 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Two polymorphs of a covalent complex between papain and a diazomethylketone inhibitor J.Pept.Res., 64, 2004
1KHP	Monoclinic form of papain/ZLFG-DAM covalent complex Descriptor: Papain, peptidic inhibitor Authors: Janowski, R, Kozak, M, Jankowska, E, Grzonka, Z, Jaskolski, M. Deposit date: 2001-11-30 Release date: 2003-09-09 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Two polymorphs of a covalent complex between papain and a diazomethylketone inhibitor J.Pept.Res., 64, 2004
1ME3	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II) Descriptor: Cruzipain, [1-(3-HYDROXY-2-OXO-1-PHENETHYL-PROPYLCARBAMOYL)2-PHENYL-ETHYL]-CARBAMIC ACID PYRIDIN-4-YLMETHYL ESTER Authors: Brinen, L.S, Huang, L, Ellman, J.A. Deposit date: 2002-08-07 Release date: 2002-12-18 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain Bioorg.Med.Chem., 11, 2003
1ME4	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I) Descriptor: CRUZIPAIN, [1-(1-BENZYL-3-HYDROXY-2-OXO-PROPYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER Authors: Brinen, L.S, Huang, L, Ellman, J.A. Deposit date: 2002-08-07 Release date: 2002-12-18 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain Bioorg.Med.Chem., 11, 2003
1MHW	Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides Descriptor: 4-biphenylacetyl-Cys-(D)Arg-Tyr-N-(2-phenylethyl) amide, Cathepsin L Authors: Chowdhury, S, Sivaraman, J, Wang, J, Devanathan, G, Lachance, P, Qi, H, Menard, R, Lefebvre, J, Konishi, Y, Cygler, M, Sulea, T, Purisima, E.O. Deposit date: 2002-08-21 Release date: 2002-12-11 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides J.Med.Chem., 45, 2002
1M6D	Crystal structure of human cathepsin F Descriptor: 4-MORPHOLIN-4-YL-PIPERIDINE-1-CARBOXYLIC ACID [1-(3-BENZENESULFONYL-1-PROPYL-ALLYLCARBAMOYL)-2-PHENYLETHYL]-AMIDE, Cathepsin F Authors: Somoza, J.R, Palmer, J.T, Ho, J.D. Deposit date: 2002-07-15 Release date: 2003-07-15 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators J.Mol.Biol., 322, 2002
1MEG	CRYSTAL STRUCTURE OF A CARICAIN D158E MUTANT IN COMPLEX WITH E-64 Descriptor: CARICAIN, ETHANOL, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE Authors: Katerelos, N.A. Deposit date: 1996-05-04 Release date: 1997-01-11 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of a caricain D158E mutant in complex with E-64. FEBS Lett., 392, 1996
1MEM	Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor Descriptor: Cathepsin K, N-{(1R)-3-phenyl-1-[2-(phenylsulfonyl)ethyl]propyl}-N~2~-(piperazin-1-ylcarbonyl)-L-leucinamide Authors: Mcgrath, M.E. Deposit date: 1997-01-08 Release date: 1998-01-14 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of human cathepsin K complexed with a potent inhibitor. Nat.Struct.Biol., 4, 1997
1MS6	Dipeptide Nitrile Inhibitor Bound to Cathepsin S. Descriptor: Cathepsin S, MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE Authors: Ward, Y.D, Thomson, D.S, Frye, L.L, Cywin, C.L, Morwick, T, Emmanuel, M.J, Zindell, R, McNeil, D, Bekkali, Y, Giradot, M, Hrapchak, M, DeTuri, M, Crane, K, White, D, Pav, S, Wang, Y, Hao, M.H, Grygon, C.A, Labadia, M.E, Freeman, D.M, Davidson, W, Hopkins, J.L, Brown, M.L, Spero, D.M. Deposit date: 2002-09-19 Release date: 2003-04-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors J.Med.Chem., 45, 2002
1NL6	Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor Descriptor: 5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ACID ((S)-3-METHYL-1-{(S)-3-OXO-1-[2-(3-PYRIDIN-2-YLPHENYL)ACETYL]AZEPAN-4-YLCARBAMOYL}BUTYL)AMIDE, Cathepsin K Authors: Smith, W.W, Janson, C.A, Zhao, B. Deposit date: 2003-01-06 Release date: 2003-01-14 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Azepanone-based inhibitors of human and rat cathepsin K J.Med.Chem., 44, 2001

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