1MHW

Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides

Summary for 1MHW

• Entry DOI: 10.2210/pdb1mhw/pdb
• Related: 1CJL
• Related PRD ID: PRD_000270
• Descriptor: Cathepsin L, 4-biphenylacetyl-Cys-(D)Arg-Tyr-N-(2-phenylethyl) amide, ... (4 entities in total)
• Functional Keywords: cathepsin l, cysteine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Lysosome: P07711 P07711
• Total number of polymer chains: 8
• Total formula weight: 50780.57

Authors

Chowdhury, S.,Sivaraman, J.,Wang, J.,Devanathan, G.,Lachance, P.,Qi, H.,Menard, R.,Lefebvre, J.,Konishi, Y.,Cygler, M.,Sulea, T.,Purisima, E.O. (deposition date: 2002-08-21, release date: 2002-12-11, Last modification date: 2017-10-11)

• Primary citation: Chowdhury, S.,Sivaraman, J.,Wang, J.,Devanathan, G.,Lachance, P.,Qi, H.,Menard, R.,Lefebvre, J.,Konishi, Y.,Cygler, M.,Sulea, T.,Purisima, E.O.; Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides; J.Med.Chem., 45:5321-5329, 2002; PubMed: 12431059; DOI: 10.1021/jm020238t

Experimental method

X-RAY DIFFRACTION (1.9 Å)