1THE

CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN

Summary for 1THE

Entry DOI	10.2210/pdb1the/pdb
Related PRD ID	PRD_000253
Descriptor	Cathepsin B, amino{[(4S)-4-{[(benzyloxy)carbonyl]amino}-5-{[(2S)-1-(benzyloxy)-4-chloro-3-oxobutan-2-yl]amino}-5-oxopentyl]amino}methaniminium (3 entities in total)
Functional Keywords	thiol protease, glycoprotein, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Lysosome: P00787
Total number of polymer chains	2
Total formula weight	57921.15
Authors	Huber, C.P.,Jia, Z. (deposition date: 1995-09-15, release date: 1996-03-10, Last modification date: 2012-12-12)
Primary citation	Jia, Z.,Hasnain, S.,Hirama, T.,Lee, X.,Mort, J.S.,To, R.,Huber, C.P. Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J.Biol.Chem., 270:5527-5533, 1995 Cited by PubMed: 7890671 DOI: 10.1074/jbc.270.10.5527 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation