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1EWO	THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204 Descriptor: CRUZAIN, N-[N'-BENZYLOXYCARBONYL-PHENYLALANINYL]-3-AMINO-5-PHENYL-PENTANE-1-SULFONIC ACID PHENYL ESTER Authors: Brinen, L.S, Gillmor, S.A, Fletterick, R.J. Deposit date: 2000-04-26 Release date: 2003-06-10 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structure of Cruzain bound to WRR-204 To be Published
1F29	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (I) Descriptor: 3-[[N-[MORPHOLIN-N-YL]-CARBONYL]-PHENYLALANINYL-AMINO]-5- PHENYL-PENTANE-1-SULFONYLBENZENE, CRUZAIN Authors: Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. Deposit date: 2000-05-23 Release date: 2000-07-26 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
1F2A	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (II) Descriptor: 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONYLMETHYLBENZENE, CRUZAIN Authors: Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. Deposit date: 2000-05-23 Release date: 2000-07-26 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
1F2B	CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (III) Descriptor: 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID 4-NITRO-PHENYL ESTER, CRUZAIN Authors: Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. Deposit date: 2000-05-23 Release date: 2000-07-26 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
1F2C	CRYSTAL STRUCTURE ANALYSIS OF CRYZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (IV) Descriptor: 3-[[N-[4-METHYL-PIPERAZINYL]CARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID BENZYLOXY-AMIDE, CRUZAIN Authors: Brinen, L.S, Hansell, E, Roush, W.R, McKerrow, J.H, Fletterick, R.J. Deposit date: 2000-05-23 Release date: 2000-07-26 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure Fold.Des., 8, 2000
2F7D	A mutant rabbit cathepsin K with a nitrile inhibitor Descriptor: (1R,2R)-N-(2-AMINOETHYL)-2-{[(4-METHOXYPHENYL)SULFONYL]METHYL}CYCLOHEXANECARBOXAMIDE, Cathepsin K Authors: Somoza, J.R. Deposit date: 2005-11-30 Release date: 2006-03-07 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K. J.Med.Chem., 49, 2006
2F1G	Cathepsin S in complex with non-covalent 2-(Benzoxazol-2-ylamino)-acetamide Descriptor: Cathepsin S, GLYCEROL, N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDE Authors: Spraggon, G, Hornsby, M, Lesley, S.A, Tully, D.C, Harris, J.L, Karenewsky, D.S, Kulathila, R, Clark, K. Deposit date: 2005-11-14 Release date: 2006-04-04 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: Heterocyclic P3. Bioorg.Med.Chem.Lett., 16, 2006
1MS6	Dipeptide Nitrile Inhibitor Bound to Cathepsin S. Descriptor: Cathepsin S, MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE Authors: Ward, Y.D, Thomson, D.S, Frye, L.L, Cywin, C.L, Morwick, T, Emmanuel, M.J, Zindell, R, McNeil, D, Bekkali, Y, Giradot, M, Hrapchak, M, DeTuri, M, Crane, K, White, D, Pav, S, Wang, Y, Hao, M.H, Grygon, C.A, Labadia, M.E, Freeman, D.M, Davidson, W, Hopkins, J.L, Brown, M.L, Spero, D.M. Deposit date: 2002-09-19 Release date: 2003-04-22 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors J.Med.Chem., 45, 2002
1NLJ	CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT AZEPANONE INHIBITOR Descriptor: BENZOFURAN-2-CARBOXYLIC ACID {(S)-3-METHYL-1-[3-OXO-1-(PYRIDIN-2-YLSULFONYL)AZEPAN-4-YLCARBAMOYL]BUTYL}AMIDE, CATHEPSIN K Authors: Smith, W.W, Janson, C.A, Zhao, B. Deposit date: 2003-01-07 Release date: 2003-01-14 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Azepanone-Based Inhibitors of Human and Rat Cathepsin K J.Med.Chem., 44, 2001
1NQC	Crystal structures of Cathepsin S inhibitor complexes Descriptor: Cathepsin S, N-[(1R)-2-(BENZYLSULFANYL)-1-FORMYLETHYL]-N-(MORPHOLIN-4-YLCARBONYL)-L-PHENYLALANINAMIDE Authors: Pauly, T.A, Sulea, T, Ammirati, M, Sivaraman, J, Danley, D.E, Griffor, M.C, Kamath, A.V, Wang, I.K, Laird, E.R, Menard, R, Cygler, M, Rath, V.L. Deposit date: 2003-01-21 Release date: 2003-04-15 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry, 42, 2003
1NL6	Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor Descriptor: 5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ACID ((S)-3-METHYL-1-{(S)-3-OXO-1-[2-(3-PYRIDIN-2-YLPHENYL)ACETYL]AZEPAN-4-YLCARBAMOYL}BUTYL)AMIDE, Cathepsin K Authors: Smith, W.W, Janson, C.A, Zhao, B. Deposit date: 2003-01-06 Release date: 2003-01-14 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Azepanone-based inhibitors of human and rat cathepsin K J.Med.Chem., 44, 2001
1ME3	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II) Descriptor: Cruzipain, [1-(3-HYDROXY-2-OXO-1-PHENETHYL-PROPYLCARBAMOYL)2-PHENYL-ETHYL]-CARBAMIC ACID PYRIDIN-4-YLMETHYL ESTER Authors: Brinen, L.S, Huang, L, Ellman, J.A. Deposit date: 2002-08-07 Release date: 2002-12-18 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain Bioorg.Med.Chem., 11, 2003
1ME4	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I) Descriptor: CRUZIPAIN, [1-(1-BENZYL-3-HYDROXY-2-OXO-PROPYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER Authors: Brinen, L.S, Huang, L, Ellman, J.A. Deposit date: 2002-08-07 Release date: 2002-12-18 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain Bioorg.Med.Chem., 11, 2003
1NPZ	Crystal structures of Cathepsin S inhibitor complexes Descriptor: Cathepsin S, N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide Authors: Pauly, T.A, Sulea, T, Ammirati, M, Sivaraman, J, Danley, D.E, Griffor, M.C, Kamath, A.V, Wang, I.K, Laird, E.R, Seddon, A.P, Menard, R, Cygler, M, Rath, V.L. Deposit date: 2003-01-20 Release date: 2003-04-15 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Specificity determinants of human cathepsin s revealed by crystal structures of complexes. Biochemistry, 42, 2003
1MEM	Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor Descriptor: Cathepsin K, N-{(1R)-3-phenyl-1-[2-(phenylsulfonyl)ethyl]propyl}-N~2~-(piperazin-1-ylcarbonyl)-L-leucinamide Authors: Mcgrath, M.E. Deposit date: 1997-01-08 Release date: 1998-01-14 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of human cathepsin K complexed with a potent inhibitor. Nat.Struct.Biol., 4, 1997
1O0E	1.9 Angstrom Crystal Structure of a plant cysteine protease Ervatamin C Descriptor: Ervatamin C, THIOSULFATE Authors: Thakurta, P.G, Chakrabarti, C, Biswas, S, Dattagupta, J.K. Deposit date: 2003-02-21 Release date: 2004-03-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Basis of the Unusual Stability and Substrate Specificity of Ervatamin C, a Plant Cysteine Protease from Ervatamia coronaria Biochemistry, 43, 2004
1PIP	CRYSTAL STRUCTURE OF PAPAIN-SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE COMPLEX AT 1.7 ANGSTROMS RESOLUTION: NONCOVALENT BINDING MODE OF A COMMON SEQUENCE OF ENDOGENOUS THIOL PROTEASE INHIBITORS Descriptor: Papain, SUCCINYL-GLN-VAL-VAL-ALA-ALA-P-NITROANILIDE Authors: Yamamoto, A, Tomoo, K, Doi, M, Ohishi, H, Inoue, M, Ishida, T, Yamamoto, D, Tsuboi, S, Okamoto, H, Okada, Y. Deposit date: 1992-10-03 Release date: 1993-10-31 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of papain-succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide complex at 1.7-A resolution: noncovalent binding mode of a common sequence of endogenous thiol protease inhibitors. Biochemistry, 31, 1992
1PE6	REFINED X-RAY STRUCTURE OF PAPAIN(DOT)E-64-C COMPLEX AT 2.1-ANGSTROMS RESOLUTION Descriptor: METHANOL, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE, PAPAIN Authors: Yamamoto, D, Matsumoto, K, Ohishi, H, Ishida, T, Inoue, M, Kitamura, K, Mizuno, H. Deposit date: 1991-05-14 Release date: 1993-04-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution. J.Biol.Chem., 266, 1991
1PPO	DETERMINATION OF THE STRUCTURE OF PAPAYA PROTEASE OMEGA Descriptor: MERCURY (II) ION, PROTEASE OMEGA Authors: Pickersgill, R.W, Rizkallah, P.J, Harris, G.W, Goodenough, P.W. Deposit date: 1991-07-12 Release date: 1993-10-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Determination of the Structure of Papaya Protease Omega Acta Crystallogr.,Sect.B, 47, 1991
1PAD	Binding of chloromethyl ketone substrate analogues to crystalline papain Descriptor: ACETYL-ALA-ALA-PHE-ALA-CHLOROMETHYLKETONE INHIBITOR, PAPAIN Authors: Drenth, J, Kalk, K.H, Swen, H.M. Deposit date: 1976-11-01 Release date: 1977-04-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Binding of chloromethyl ketone substrate analogues to crystalline papain. Biochemistry, 15, 1976
1MEG	CRYSTAL STRUCTURE OF A CARICAIN D158E MUTANT IN COMPLEX WITH E-64 Descriptor: CARICAIN, ETHANOL, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE Authors: Katerelos, N.A. Deposit date: 1996-05-04 Release date: 1997-01-11 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of a caricain D158E mutant in complex with E-64. FEBS Lett., 392, 1996
1POP	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A PAPAIN-LEUPEPTIN COMPLEX Descriptor: LEUPEPTIN, METHANOL, PAPAIN Authors: Schroder, E, Crawford, C. Deposit date: 1993-06-24 Release date: 1993-10-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: X-ray crystallographic structure of a papain-leupeptin complex. FEBS Lett., 315, 1993
1PPN	STRUCTURE OF MONOCLINIC PAPAIN AT 1.60 ANGSTROMS RESOLUTION Descriptor: METHANOL, PAPAIN, UNKNOWN LIGAND Authors: Pickersgill, R.W, Harris, G.W, Garman, E. Deposit date: 1991-10-25 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structure of Monoclinic Papain at 1.60 Angstroms Resolution Acta Crystallogr.,Sect.B, 48, 1992
1PPP	CRYSTAL STRUCTURE OF PAPAIN-E64-C COMPLEX. BINDING DIVERSITY OF E64-C TO PAPAIN S2 AND S3 SUBSITES Descriptor: METHANOL, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE, PAPAIN Authors: Ishida, T. Deposit date: 1993-03-17 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsites. Biochem.J., 287, 1992
1PPD	RESTRAINED LEAST-SQUARES REFINEMENT OF THE SULFHYDRYL PROTEASE PAPAIN TO 2.0 ANGSTROMS Descriptor: 2-HYDROXYETHYL-THIOPAPAIN, BETA-MERCAPTOETHANOL Authors: Jansonius, J.N. Deposit date: 1984-11-06 Release date: 1985-01-02 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Restrained Least-Squares Refinement of the Sulfhydryl Protease Papain to 2.0 Angstroms Acta Crystallogr.,Sect.A, 40, 1984

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