PDB: 2435 件ウェブページステータス検索Chemie searchBIRD

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5K19	Crystal structure of WD repeat-containing protein 20 分子名称: GLYCEROL, SULFATE ION, WD repeat-containing protein 20 著者 Li, H, D'Andrea, A.D, Zheng, N. 登録日 2016-05-17 公開日 2016-07-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.602 Å) 主引用文献 Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20. Mol.Cell, 63, 2016
5MWJ	Structure Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1 分子名称: DIMETHYL SULFOXIDE, Transducin-like enhancer protein 1, pepide inhibtor 著者 McGrath, S, Tortorici, M, Vidler, L, Drouin, L, Westwood, I, Gimeson, P, Van Montfort, R, Hoelder, S. 登録日 2017-01-18 公開日 2017-04-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1. Chemistry, 23, 2017
5N4A	Crystal structure of Chlamydomonas IFT80 分子名称: GLYCEROL, Intraflagellar transport protein 80, OXALATE ION 著者 Taschner, M, Mourao, A. 登録日 2017-02-10 公開日 2018-02-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis. Elife, 7, 2018
5K0M	Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED 分子名称: (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}pyrrolidin-3-amine, Polycomb protein EED 著者 Jakob, C.G, Bigelow, L.J, Zhu, H, Sun, C. 登録日 2016-05-17 公開日 2017-01-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat. Chem. Biol., 13, 2017
5NAF	Co-crystal structure of an MeCP2 peptide with TBLR1 WD40 domain 分子名称: F-box-like/WD repeat-containing protein TBL1XR1, GLYCEROL, Methyl-CpG-binding protein 2 著者 Kruusvee, V, Cook, A.G. 登録日 2017-02-27 公開日 2017-03-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.493 Å) 主引用文献 Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3I2N	Crystal Structure of WD40 repeats protein WDR92 分子名称: WD repeat-containing protein 92 著者 Amaya, M.F, Li, Z, He, H, Seitova, A, Ni, S, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) 登録日 2009-06-29 公開日 2009-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure and function of WD40 domain proteins. Protein Cell, 2, 2011
5NNZ	Crystal structure of human ODA16 分子名称: Dynein assembly factor with WDR repeat domains 1 著者 Lorentzen, E, Taschner, T, Basquin, J. 登録日 2017-04-10 公開日 2017-06-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.651 Å) 主引用文献 Purification and crystal structure of human ODA16: Implications for ciliary import of outer dynein arms by the intraflagellar transport machinery. Protein Sci., 29, 2020
3IIY	Crystal structure of Eed in complex with a trimethylated histone H1K26 peptide 分子名称: Histone H1K26 peptide, Polycomb protein EED 著者 Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J. 登録日 2009-08-03 公開日 2009-09-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 461, 2009
3IIW	Crystal structure of Eed in complex with a trimethylated histone H3K27 peptide 分子名称: Histone H3 peptide, Polycomb protein EED 著者 Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J. 登録日 2009-08-03 公開日 2009-09-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 461, 2009
5M23	Modulation of MLL1 Methyltransferase Activity 分子名称: 4-[(~{E})-[4-[[[(2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-pentanoyl]amino]propanoyl]amino]methyl]phenyl]diazenyl]-~{N}-[(2~{S})-3-methyl-1-oxidanylidene-butan-2-yl]benzamide, WD repeat-containing protein 5 著者 Srinivasan, V. 登録日 2016-10-11 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia. Chem Sci, 8, 2017
3IJ0	Crystal structure of Eed in complex with a trimethylated histone H3K9 peptide 分子名称: Histone H3K9 peptide, Polycomb protein EED 著者 Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J. 登録日 2009-08-03 公開日 2009-09-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 461, 2009
3IJC	Crystal structure of Eed in complex with NDSB-195 分子名称: ETHYL DIMETHYL AMMONIO PROPANE SULFONATE, Polycomb protein EED 著者 Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J. 登録日 2009-08-04 公開日 2009-09-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 461, 2009
5MZH	Crystal structure of ODA16 from Chlamydomonas reinhardtii 分子名称: Dynein assembly factor with WDR repeat domains 1, SULFATE ION 著者 Lorentzen, E, Taschner, M, Basquin, J, Mourao, A. 登録日 2017-01-31 公開日 2017-03-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.398 Å) 主引用文献 Structural basis of outer dynein arm intraflagellar transport by the transport adaptor protein ODA16 and the intraflagellar transport protein IFT46. J. Biol. Chem., 292, 2017
5N1A	Crystal structure of Utp4 from Chaetomium thermophilum 分子名称: utp4 著者 Calvino, F.R, Ahmed, Y.L, Wild, K, Sinning, I. 登録日 2017-02-05 公開日 2017-06-14 最終更新日 2019-10-16 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural basis for 5'-ETS recognition by Utp4 at the early stages of ribosome biogenesis. PLoS ONE, 12, 2017
3IJ1	Crystal structure of Eed in complex with a trimethylated histone H4K20 peptide 分子名称: Histone H4K20 peptide, Polycomb protein EED 著者 Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J. 登録日 2009-08-03 公開日 2009-09-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Role of the polycomb protein EED in the propagation of repressive histone marks. Nature, 461, 2009
5KWN	The WD domain ofArabidopsis thaliana E3 Ubiquitin Ligase COP1 in complex with peptide from HY5 分子名称: E3 ubiquitin-protein ligase COP1, peptide 16-mer 著者 Uljon, S, Blacklow, S. 登録日 2016-07-18 公開日 2017-07-26 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 The COP1 WD domain in complex with HY5 peptide To Be Published
3JRP	SEC13 with NUP145C (AA109-179) insertion blade 分子名称: FUSION PROTEIN OF PROTEIN TRANSPORT PROTEIN SEC13 AND NUCLEOPORIN NUP145 著者 Brohawn, S.G, Gogola, M, Schwartz, T.U. 登録日 2009-09-08 公開日 2009-10-27 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice. Nat.Struct.Mol.Biol., 16, 2009
3JZN	Structure of EED in apo form 分子名称: Polycomb protein EED 著者 Xu, C, Bian, C.B, Ouyang, H, Qiu, W, MacKenzie, F, Min, J, Structural Genomics Consortium (SGC) 登録日 2009-09-23 公開日 2009-12-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
5M2N	Crystal Structure of Elongator subunit Elp2 分子名称: Elongator complex protein 2 著者 Glatt, S, Mueller, C.W. 登録日 2016-10-13 公開日 2016-12-28 最終更新日 2017-09-06 実験手法 X-RAY DIFFRACTION (2.812 Å) 主引用文献 Architecture of the yeast Elongator complex. EMBO Rep., 18, 2017
5M25	Modulation of MLL1 Methyltransferase Activity 分子名称: (2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-~{N}-[(2~{S})-1-[[4-[(~{E})-[4-(hydroxymethyl)phenyl]diazenyl]phenyl]methylamino]-1-oxidanylidene-propan-2-yl]pentanamide, WD repeat-containing protein 5 著者 Srinivasan, V. 登録日 2016-10-11 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia. Chem Sci, 8, 2017
5M89	Spliceosome component 分子名称: Spliceosome WD40 Sc 著者 Moura, T.R, Pena, V. 登録日 2016-10-28 公開日 2018-03-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.605 Å) 主引用文献 Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors. Mol. Cell, 69, 2018
3K27	Complex structure of EED and trimethylated H3K9 分子名称: HISTONE PEPTIDE, Polycomb protein EED 著者 Bian, C.B, Xu, C, Qiu, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2009-09-29 公開日 2009-12-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
3JPX	EED: A Novel Histone Trimethyllysine Binder Within The EED-EZH2 Polycomb Complex 分子名称: HISTONE PEPTIDE, Polycomb protein EED 著者 Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2009-09-04 公開日 2009-10-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
3JZG	Structure of EED in complex with H3K27me3 分子名称: HISTONE PEPTIDE, Polycomb protein EED 著者 Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2009-09-23 公開日 2009-12-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
5NUV	Structure of the WD40-domain of human ATG16L1 分子名称: (R,R)-2,3-BUTANEDIOL, Autophagy-related protein 16-1 著者 Bajagic, M, Scrima, A. 登録日 2017-05-02 公開日 2017-07-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure of the WD40-domain of human ATG16L1. Protein Sci., 26, 2017

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