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5MWJ

Structure Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1

Summary for 5MWJ
Entry DOI10.2210/pdb5mwj/pdb
DescriptorTransducin-like enhancer protein 1, DIMETHYL SULFOXIDE, pepide inhibtor, ... (4 entities in total)
Functional Keywordstransducin-like; constrained peptide inhibitor; transcriptional corepressor, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight75475.07
Authors
McGrath, S.,Tortorici, M.,Vidler, L.,Drouin, L.,Westwood, I.,Gimeson, P.,Van Montfort, R.,Hoelder, S. (deposition date: 2017-01-18, release date: 2017-04-05, Last modification date: 2024-01-17)
Primary citationMcGrath, S.,Tortorici, M.,Drouin, L.,Solanki, S.,Vidler, L.,Westwood, I.,Gimeson, P.,Van Montfort, R.,Hoelder, S.
Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1.
Chemistry, 23:9577-9584, 2017
Cited by
PubMed: 28326635
DOI: 10.1002/chem.201700747
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.04 Å)
Structure validation

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