5M25

Modulation of MLL1 Methyltransferase Activity

Summary for 5M25

Entry DOI	10.2210/pdb5m25/pdb
Descriptor	WD repeat-containing protein 5, (2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-azanyl-3-oxidanyl-propanoyl]amino]propanoyl]amino]-5-carbamimidamido-~{N}-[(2~{S})-1-[[4-[(~{E})-[4-(hydroxymethyl)phenyl]diazenyl]phenyl]methylamino]-1-oxidanylidene-propan-2-yl]pentanamide (3 entities in total)
Functional Keywords	mll1 methyltransferase peptide complex wdr5, transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P61964
Total number of polymer chains	1
Total formula weight	48739.01
Authors	Srinivasan, V. (deposition date: 2016-10-11, release date: 2017-06-28, Last modification date: 2024-01-17)
Primary citation	Albert, L.,Xu, J.,Wan, R.,Srinivasan, V.,Dou, Y.,Vazquez, O. Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia. Chem Sci, 8:4612-4618, 2017 Cited by PubMed: 28970883 DOI: 10.1039/c7sc00137a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation