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8R5W
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Crystal structure of the three anaphylatoxin-like modules in fibulin-2
分子名称: Fibulin-2
著者Sohail, A.A, Koski, M.K, Ruddock, L.W.
登録日2023-11-18
公開日2024-07-10
最終更新日2024-07-17
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Biophysical and structural studies of fibulin-2.
Sci Rep, 14, 2024
4UU9
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Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody
分子名称: COMPLEMENT C5, MEDI7814, SULFATE ION
著者Colley, C, Sridharan, S, Dobson, C, Popovic, B, Debreczeni, J.E, Hargreaves, D, Edwards, B, Brennan, J, England, L, Fung, S, An Eghobamien, L, Sivars, U, Woods, R, Flavell, L, Renshaw, G.J, Wickson, K, Wilkinson, T, Davies, R, Bonnell, J, Warrener, P, Howes, R, Vaughan, T.
登録日2014-07-25
公開日2015-08-12
最終更新日2019-02-27
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.
MAbs, 10, 2018
5B4P
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BU of 5b4p by Molmil
Complex structure of human C5a and its binding repebody
分子名称: C5a anaphylatoxin, PENTAETHYLENE GLYCOL, SULFATE ION, ...
著者Kim, H.-S, Choi, J.M, Hwang, D.E.
登録日2016-04-12
公開日2017-04-12
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Complex structure of human C5a and its binding repebody
To Be Published
1KJS
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NMR SOLUTION STRUCTURE OF C5A AT PH 5.2, 303K, 20 STRUCTURES
分子名称: C5A
著者Zhang, X, Boyar, W, Toth, M, Wennogle, L, Gonnella, N.C.
登録日1997-01-09
公開日1997-05-15
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Structural definition of the C5a C terminus by two-dimensional nuclear magnetic resonance spectroscopy.
Proteins, 28, 1997
1C5A
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BU of 1c5a by Molmil
THREE-DIMENSIONAL STRUCTURE OF PORCINE C5ADES*ARG FROM 1H NUCLEAR MAGNETIC RESONANCE DATA
分子名称: COMPLEMENT C5A ANAPHYLATOXIN
著者Williamson, M.P, Madison, V.S.
登録日1990-06-12
公開日1991-10-15
最終更新日2022-02-16
実験手法SOLUTION NMR
主引用文献Three-dimensional structure of porcine C5adesArg from 1H nuclear magnetic resonance data.
Biochemistry, 29, 1990
1CFA
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BU of 1cfa by Molmil
SOLUTION STRUCTURE OF A SEMI-SYNTHETIC C5A RECEPTOR ANTAGONIST AT PH 5.2, 303K, NMR, 20 STRUCTURES
分子名称: COMPLEMENT 5A SEMI-SYNTHETIC ANTAGONIST, SYNTHETIC N-TERMINAL TAIL
著者Zhang, X, Boyar, W, Galakatos, N, Gonnella, N.C.
登録日1996-09-21
公開日1997-09-17
最終更新日2024-06-05
実験手法SOLUTION NMR
主引用文献Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.
Protein Sci., 6, 1997
4WB3
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BU of 4wb3 by Molmil
Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a-desArg complement anaphylatoxin
分子名称: ACETATE ION, CALCIUM ION, Complement C5, ...
著者Yatime, L, Maasch, C, Hoehlig, K, Klussmann, S, Vater, A, Andersen, G.R.
登録日2014-09-02
公開日2015-05-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
Nat Commun, 6, 2015
4WB2
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Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a complement anaphylatoxin
分子名称: ACETATE ION, CALCIUM ION, Complement C5, ...
著者Yatime, L, Maasch, C, Hoehlig, K, Klussmann, S, Vater, A, Andersen, G.R.
登録日2014-09-02
公開日2015-05-06
最終更新日2023-07-26
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.
Nat Commun, 6, 2015
6JV7
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Chimeric Rat C5a
分子名称: Chimeric-rC5a, D-anaphylatoxin C5a, SULFATE ION
著者Zuo, C.
登録日2019-04-16
公開日2020-04-22
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.309 Å)
主引用文献Chimeric protein probes for C5a receptors through fusion of anaphylatoxin C5a core region with a small-molecule antagonist
To Be Published
3HQB
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Crystal structure of human desarg-C5A
分子名称: Complement C5
著者Cook, W.J, Ealick, S.E.
登録日2009-06-05
公開日2010-02-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.299 Å)
主引用文献Structure of human desArg-C5a.
Acta Crystallogr.,Sect.D, 66, 2010
3HQA
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Crystal structure of human desarg-C5A
分子名称: Complement C5
著者Cook, W.J, Ealick, S.E.
登録日2009-06-05
公開日2010-02-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.586 Å)
主引用文献Structure of human desArg-C5a.
Acta Crystallogr.,Sect.D, 66, 2010
6JV8
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Crystal structure of Rat C5a
分子名称: Complement C5
著者Zuo, C.
登録日2019-04-16
公開日2020-04-22
実験手法X-RAY DIFFRACTION (1.582 Å)
主引用文献Chimeric protein probes for C5a receptors through fusion of anaphylatoxin C5a core region with a small-molecule antagonist
To Be Published
4HW5
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Crystal Structure of the Human C3a anaphylatoxin
分子名称: Complement C3, SULFATE ION
著者Bajic, G, Yatime, L, Andersen, G.R.
登録日2012-11-07
公開日2012-12-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg.
Protein Sci., 22, 2013
4I6O
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BU of 4i6o by Molmil
Crystal structure of chemically synthesized human anaphylatoxin C3a
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Complement C3
著者Wang, C.I.A, Ghassemian, A, Collins, B, Lewis, R.J, Alewood, P.F, Durek, T.
登録日2012-11-29
公開日2013-02-27
最終更新日2013-03-06
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Efficient chemical synthesis of human complement protein C3a.
Chem.Commun.(Camb.), 49, 2013
4HWJ
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Crystal Structure of the Human C3a desArg anaphylatoxin
分子名称: Complement C3, SULFATE ION
著者Bajic, G, Yatime, L, Andersen, G.R.
登録日2012-11-08
公開日2012-12-12
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg.
Protein Sci., 22, 2013
4P3B
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BU of 4p3b by Molmil
Crystal structure of the mouse C5a-desArg anaphylatoxin
分子名称: Complement C5, FORMIC ACID
著者Yatime, L, Schatz-Jakobsen, J.A, Andersen, G.R.
登録日2014-03-06
公開日2014-06-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and functional characterization of human and murine C5a anaphylatoxins.
Acta Crystallogr. D Biol. Crystallogr., 70, 2014
4P3A
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BU of 4p3a by Molmil
Crystal structure of the mouse C5a anaphylatoxin
分子名称: Complement C5, FORMIC ACID
著者Yatime, L, Schatz-Jakobsen, J.A, Andersen, G.R.
登録日2014-03-06
公開日2014-06-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural and functional characterization of human and murine C5a anaphylatoxins.
Acta Crystallogr. D Biol. Crystallogr., 70, 2014
4P39
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Crystal structure of the human C5aR antagonist C5a-A8
分子名称: Complement C5
著者Yatime, L, Schatz-Jakobsen, J.A, Larsen, C, Andersen, G.R.
登録日2014-03-06
公開日2014-06-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Structural and functional characterization of human and murine C5a anaphylatoxins.
Acta Crystallogr. D Biol. Crystallogr., 70, 2014
2A73
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BU of 2a73 by Molmil
Human Complement Component C3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Janssen, B.J.C, Huizinga, E.G, Raaijmakers, H.C.A, Roos, A, Daha, M.R, Nilsson-Ekdahl, K, Nilsson, B, Gros, P.
登録日2005-07-04
公開日2005-09-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structures of complement component C3 provide insights into the function and evolution of immunity.
Nature, 437, 2005
8CEM
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BU of 8cem by Molmil
Structure of bovine native C3, re-refinement
分子名称: Complement C3 alpha chain, Complement C3 beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Andersen, G.R, Fredslund, F.
登録日2023-02-02
公開日2023-04-05
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The structure of bovine complement component 3 reveals the basis for thioester function.
J Mol Biol, 361, 2006
4E0S
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BU of 4e0s by Molmil
Crystal Structure of C5b-6
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C5, ...
著者Aleshin, A.E, Stec, B, DiScipio, R, Liddington, R.C.
登録日2012-03-05
公開日2012-04-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (4.21 Å)
主引用文献Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287, 2012
3CU7
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Human Complement Component 5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
著者Fredslund, F, Andersen, G.R.
登録日2008-04-16
公開日2008-06-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.105 Å)
主引用文献Structure of and influence of a tick complement inhibitor on human complement component 5
Nat.Immunol., 9, 2008
7Y64
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Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein
分子名称: C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H.
登録日2022-06-18
公開日2023-03-01
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
3KLS
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Structure of complement C5 in complex with SSL7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
著者Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
登録日2009-11-09
公開日2009-11-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3KM9
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Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
著者Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
登録日2009-11-10
公開日2009-12-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010

 

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