4UU9

Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody

Summary for 4UU9

• Entry DOI: 10.2210/pdb4uu9/pdb
• Descriptor: MEDI7814, COMPLEMENT C5, SULFATE ION, ... (5 entities in total)
• Functional Keywords: immune system, fv, complement system
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 6
• Total formula weight: 67413.27

Authors

Colley, C.,Sridharan, S.,Dobson, C.,Popovic, B.,Debreczeni, J.E.,Hargreaves, D.,Edwards, B.,Brennan, J.,England, L.,Fung, S.,An Eghobamien, L.,Sivars, U.,Woods, R.,Flavell, L.,Renshaw, G.J.,Wickson, K.,Wilkinson, T.,Davies, R.,Bonnell, J.,Warrener, P.,Howes, R.,Vaughan, T. (deposition date: 2014-07-25, release date: 2015-08-12, Last modification date: 2019-02-27)

• Primary citation: Colley, C.S.,Popovic, B.,Sridharan, S.,Debreczeni, J.E.,Hargeaves, D.,Fung, M.,An, L.L.,Edwards, B.,Arnold, J.,England, E.,Eghobamien, L.,Sivars, U.,Flavell, L.,Renshaw, J.,Wickson, K.,Warrener, P.,Zha, J.,Bonnell, J.,Woods, R.,Wilkinson, T.,Dobson, C.,Vaughan, T.J.; Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors.; MAbs, 10:104-117, 2018; PubMed: 28952876; DOI: 10.1080/19420862.2017.1384892

Experimental method

X-RAY DIFFRACTION (2.12 Å)