4WB2

Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a complement anaphylatoxin

Summary for 4WB2

Entry DOI	10.2210/pdb4wb2/pdb
Descriptor	Complement C5, mixed L-RNA/L-DNA mirror-image aptamer NOX-D20 (40-MER), ACETATE ION, ... (6 entities in total)
Functional Keywords	protein-rna complex, mirror-image aptamer, g-quadruplex, complement anaphylatoxin, dna-rna hybrid
Biological source	Mus musculus (House Mouse) More
Cellular location	Secreted: P06684
Total number of polymer chains	5
Total formula weight	53699.52
Authors	Yatime, L.,Maasch, C.,Hoehlig, K.,Klussmann, S.,Vater, A.,Andersen, G.R. (deposition date: 2014-09-02, release date: 2015-05-06, Last modification date: 2023-07-26)
Primary citation	Yatime, L.,Maasch, C.,Hoehlig, K.,Klussmann, S.,Andersen, G.R.,Vater, A. Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer. Nat Commun, 6:6481-6481, 2015 Cited by PubMed: 25901944 DOI: 10.1038/ncomms7481 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation