PDB: 141 件ウェブページステータス検索Chemie searchBIRD

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8C7D	Structure of the GEF Kalirin DH2 Domain 分子名称: Kalirin 著者 Callens, M.C, Thompson, A.P, Gray, J.L, Bountra, C, von Delft, F, Brennan, P.E. 登録日 2023-01-14 公開日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Structure-based alignment and analysis of RHO selectivity of RHO-DBL GTPase exchange factors to be published
2KR9	Kalirin DH1 NMR structure 分子名称: Kalirin 著者 Gorbatyuk, V.Y, Schiller, M.R, Hoch, J.C. 登録日 2009-12-10 公開日 2010-12-15 最終更新日 2024-05-08 実験手法 SOLUTION NMR 主引用文献 The solution NMR structure of the first Dbl domain of RhoGEF Kalirin. To be Published
3EO2	Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein 分子名称: Neuroepithelial cell-transforming gene 1 protein, UNKNOWN ATOM OR ION 著者 Nedyalkova, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2008-09-26 公開日 2008-10-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein To be Published
1BY1	DBL homology domain from beta-PIX 分子名称: PROTEIN (PIX) 著者 Aghazadeh, B, Zhu, K, Kubiseski, T.J, Liu, G.A, Pawson, T, Zheng, Y, Rosen, M.K. 登録日 1998-10-22 公開日 1999-10-24 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Structure and Mutagenesis of the Dbl Homology Domain Nat.Struct.Biol., 5, 1998
5N7E	Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4). 分子名称: Breakpoint cluster region protein, Mb(Bcr-DH_4) 著者 Reckel, S, Reynaud, A, Pojer, F, Hantschel, O. 登録日 2017-02-20 公開日 2017-12-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.647 Å) 主引用文献 Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat Commun, 8, 2017
5N6R	Solution structure of the Dbl-homology domain of Bcr-Abl 分子名称: Breakpoint cluster region protein 著者 Reckel, S, Lohr, F, Buchner, L, Guntert, P, Dotsch, V, Hantschel, O. 登録日 2017-02-16 公開日 2017-12-27 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat Commun, 8, 2017
1F5X	NMR STRUCTURE OF THE Y174 AUTOINHIBITED DBL HOMOLOGY DOMAIN 分子名称: RHO-GEF VAV 著者 Aghazadeh, B, Rosen, M.K, Lowry, W.E, Huang, X.Y. 登録日 2000-06-18 公開日 2000-09-15 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell(Cambridge,Mass.), 102, 2000
4D0O	AKAP13 (AKAP-Lbc) DH domain 分子名称: A-KINASE ANCHOR PROTEIN 13 著者 Abdul Azeez, K.R, Shrestha, L, Krojer, T, Allerston, C, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Klussmann, E, Elkins, J.M. 登録日 2014-04-29 公開日 2014-05-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex. Biochem.J., 464, 2014
4GYV	Crystal structure of the DH domain of FARP2 分子名称: FERM, RhoGEF and pleckstrin domain-containing protein 2 著者 He, X, Zhang, X. 登録日 2012-09-05 公開日 2013-03-13 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
2Z0Q	Crystal structure of DH-PH domain of RhoGEF3(Xpln) 分子名称: Rho guanine nucleotide exchange factor 3, SULFATE ION 著者 Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-05-07 公開日 2008-05-13 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structure of the Rho-specific guanine nucleotide-exchange factor Xpln Acta Crystallogr.,Sect.F, 68, 2012
4MT6	Crystal structure of closed inactive collybistin 分子名称: Rho guanine nucleotide exchange factor 9 著者 Schneeberger, D, Schindelin, H. 登録日 2013-09-19 公開日 2014-08-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (5.501 Å) 主引用文献 A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. Embo J., 33, 2014
1RJ2	Crystal structure of the DH/PH fragment of Dbs without bound GTPase 分子名称: Guanine nucleotide exchange factor DBS [Fragment] 著者 Worthylake, D.K, Rossman, K.L, Sondek, J. 登録日 2003-11-18 公開日 2004-06-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of the DH/PH fragment of Dbs without bound GTPase. Structure, 12, 2004
1TXD	Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF 分子名称: Rho guanine nucleotide exchange factor 12 著者 Kristelly, R, Gao, G, Tesmer, J.J. 登録日 2004-07-03 公開日 2004-09-21 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. J.Biol.Chem., 279, 2004
4MT7	Crystal structure of collybistin I 分子名称: Rho guanine nucleotide exchange factor 9 著者 Schneeberger, D, Schindelin, H. 登録日 2013-09-19 公開日 2014-08-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. Embo J., 33, 2014
1DBH	DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1 分子名称: PROTEIN (HUMAN SOS 1) 著者 Soisson, S.M, Kuriyan, J. 登録日 1998-12-17 公開日 1998-12-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell(Cambridge,Mass.), 95, 1998
5HZJ	Crystal structure of photoinhibitable Intersectin1 containing wildtype LOV2 domain 分子名称: FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1 著者 Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. 登録日 2016-02-02 公開日 2016-12-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Engineering extrinsic disorder to control protein activity in living cells. Science, 354, 2016
5HZI	Crystal structure of photoinhibitable Intersectin1 containing C450M mutant LOV2 domain 分子名称: FLAVIN MONONUCLEOTIDE, Intersectin-1,NPH1-1,Intersectin-1 著者 Tarnawski, M, Dagliyan, O, Chu, P.H, Shirvanyants, D, Dokholyan, N.V, Hahn, K.M, Schlichting, I. 登録日 2016-02-02 公開日 2016-12-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Engineering extrinsic disorder to control protein activity in living cells. Science, 354, 2016
3GF9	Crystal structure of human Intersectin 2 RhoGEF domain 分子名称: Intersectin 2, UNKNOWN ATOM OR ION 著者 Shen, Y, Tong, Y, Tempel, W, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2009-02-26 公開日 2009-03-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of human Intersectin 2 RhoGEF domain To be Published
3ODX	Crystal Structure of an N-terminally Truncated Linker-DH/PH Domains of p115-RhoGEF 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-08-12 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
3ODO	Crystal Structure of the DH/PH Domains of p115-RhoGEF 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-08-11 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
3ODW	Crystal Structure of the Linker-DH/PH domains of p115-RhoGEF 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-08-11 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
3P6A	Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant) 分子名称: Rho guanine nucleotide exchange factor 1 著者 Chen, Z, Guo, L, Sprang, S.R, Sternweis, P.C. 登録日 2010-10-11 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoREF Protein Sci., 20, 2011
5FI1	Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42 分子名称: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein 著者 Cash, J.N, Tesmer, J.J.G. 登録日 2015-12-22 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.203 Å) 主引用文献 Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure, 24, 2016
4YON	P-Rex1:Rac1 complex 分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1 著者 Lucato, C.M, Whisstock, J.C, Ellisdon, A.M. 登録日 2015-03-11 公開日 2015-07-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells. J.Biol.Chem., 290, 2015
6PCV	Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 著者 Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G. 登録日 2019-06-18 公開日 2019-10-23 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold. Sci Adv, 5, 2019

 

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