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2CLX	4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects Descriptor: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, CELL DIVISION PROTEIN KINASE 2 Authors: Krystof, V, Cankar, P, Frysova, I, Slouka, J, Kontopidis, G, Dzubak, P, Hajduch, M, Deazevedo, W.F, Paprskarova, M, Orsag, M, Rolcik, J, Latr, A, Fischer, P.M, Strnad, M. Deposit date: 2006-05-02 Release date: 2006-11-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: 4-Arylazo-3,5-Diamino-1H-Pyrazole Cdk Inhibitors: Sar Study, Crystal Structure in Complex with Cdk2, Selectivity, and Cellular Effects J.Med.Chem., 49, 2006
2DVW	Structure of the Oncoprotein Gankyrin in Complex with S6 ATPase of the 26S Proteasome Descriptor: 26S protease regulatory subunit 6B, 26S proteasome non-ATPase regulatory subunit 10 Authors: Yokoyama, S, Padmanabhan, B, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-08-01 Release date: 2007-03-13 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the Oncoprotein Gankyrin in Complex with S6 ATPase of the 26S Proteasome Structure, 15, 2007
1M1D	TETRAHYMENA GCN5 WITH BOUND BISUBSTRATE ANALOG INHIBITOR Descriptor: HISTONE H3, TGCN5 HISTONE ACETYL TRANSFERASE Authors: Poux, A.N, Cebrat, M, Kim, C.M, Cole, P.A, Marmorstein, R. Deposit date: 2002-06-18 Release date: 2002-10-30 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor. Proc.Natl.Acad.Sci.USA, 99, 2002
7PE8	cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-08 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEA	cryo-EM structure of DEPTOR bound to human mTOR complex 1, overall refinement Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-08 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (4.07 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEC	cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-08 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (4.24 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PEB	cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer Descriptor: DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, Regulatory-associated protein of mTOR, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-08 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (3.67 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PE9	cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-08 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
7PE7	cryo-EM structure of DEPTOR bound to human mTOR complex 2, overall refinement Descriptor: ACETYL GROUP, DEP domain-containing mTOR-interacting protein, INOSITOL HEXAKISPHOSPHATE, ... Authors: Waelchli, M, Maier, T. Deposit date: 2021-08-09 Release date: 2021-09-15 Last modified: 2021-09-29 Method: ELECTRON MICROSCOPY (3.41 Å) Cite: Regulation of human mTOR complexes by DEPTOR. Elife, 10, 2021
1TR4	Solution structure of human oncogenic protein gankyrin Descriptor: 26S proteasome non-ATPase regulatory subunit 10 Authors: Yuan, C, Li, J, Mahajan, A, Poi, M.J, Byeon, I.J, Tsai, M.D. Deposit date: 2004-06-19 Release date: 2004-11-16 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Solution structure of the human oncogenic protein gankyrin containing seven ankyrin repeats and analysis of its structure--function relationship. Biochemistry, 43, 2004
5UQ3	Crystal structure of human Cdk2-Spy1-P27 ternary complex Descriptor: Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, Speedy protein A Authors: McGrath, D.A, Tripathi, S.M, Rubin, S.M. Deposit date: 2017-02-06 Release date: 2017-07-05 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins. EMBO J., 36, 2017
5ER5	Crystal Structure of Calcium-loaded S100B bound to SC1990 Descriptor: CALCIUM ION, ETHIDIUM, Protein S100-B Authors: Cavalier, M.C, Melville, Z.E, Aligholizadeh, E, Fang, L, Alasady, M.J, Pierce, A.D, Wilder, P.T, MacKerell Jr, A.D, Weber, D.J. Deposit date: 2015-11-13 Release date: 2016-06-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Novel protein-inhibitor interactions in site 3 of Ca(2+)-bound S100B as discovered by X-ray crystallography. Acta Crystallogr D Struct Biol, 72, 2016
5ER4	Crystal Structure of Calcium-loaded S100B bound to SC0025 Descriptor: 6-methyl-5,6,6~{a},7-tetrahydro-4~{H}-dibenzo[de,g]quinoline-10,11-diol, CALCIUM ION, Protein S100-B Authors: Cavalier, M.C, Melville, Z.E, Aligholizadeh, E, Fang, L, Alasady, M.J, Pierce, A.D, Wilder, P.T, MacKerell Jr, A.D, Weber, D.J. Deposit date: 2015-11-13 Release date: 2016-06-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.813 Å) Cite: Novel protein-inhibitor interactions in site 3 of Ca(2+)-bound S100B as discovered by X-ray crystallography. Acta Crystallogr D Struct Biol, 72, 2016
2VXD	The structure of the C-terminal domain of Nucleophosmin Descriptor: NUCLEOPHOSMIN Authors: Bycroft, M, Grummitt, C.G. Deposit date: 2008-07-03 Release date: 2008-07-15 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia. J.Biol.Chem., 283, 2008
8FLE	Human nuclear pre-60S ribosomal subunit (State L2) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Vanden Broeck, A, Klinge, S. Deposit date: 2022-12-21 Release date: 2023-07-12 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.48 Å) Cite: Principles of human pre-60 S biogenesis. Science, 381, 2023
8FLD	Human nuclear pre-60S ribosomal subunit (State L1) Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Vanden Broeck, A, Klinge, S. Deposit date: 2022-12-21 Release date: 2023-07-12 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (2.58 Å) Cite: Principles of human pre-60 S biogenesis. Science, 381, 2023
6OLI	Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC) Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... Authors: Li, W, Cate, J.H.D. Deposit date: 2019-04-16 Release date: 2019-06-19 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule. Nat.Struct.Mol.Biol., 26, 2019
6OM0	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... Authors: Li, W, Cate, J.H.D. Deposit date: 2019-04-17 Release date: 2019-06-19 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule. Nat.Struct.Mol.Biol., 26, 2019
6OLF	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... Authors: Li, W, Cate, J.H.D. Deposit date: 2019-04-16 Release date: 2019-06-19 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule. Nat.Struct.Mol.Biol., 26, 2019
6OLE	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... Authors: Li, W, Cate, J.H.D. Deposit date: 2019-04-16 Release date: 2019-06-19 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule. Nat.Struct.Mol.Biol., 26, 2019
6OM7	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... Authors: Li, W, Cate, J.H.D. Deposit date: 2019-04-18 Release date: 2019-06-19 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule. Nat.Struct.Mol.Biol., 26, 2019
8GLP	mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure) Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... Authors: Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Watson, Z.L, Altman, R.B, Blanchard, S.C. Deposit date: 2023-03-22 Release date: 2023-04-19 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (1.67 Å) Cite: mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
8G61	mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state) Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... Authors: Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. Deposit date: 2023-02-14 Release date: 2023-04-19 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
8G60	mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state) Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... Authors: Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. Deposit date: 2023-02-14 Release date: 2023-04-19 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.54 Å) Cite: mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023
8G5Z	mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state) Descriptor: 1,4-DIAMINOBUTANE, 18S rRNA, 28S rRNA, ... Authors: Holm, M, Natchiar, K.S, Rundlet, E.J, Myasnikov, A.G, Altman, R.B, Blanchard, S.C. Deposit date: 2023-02-14 Release date: 2023-04-19 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.64 Å) Cite: mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature, 617, 2023

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