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2W0T
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BU of 2w0t by Molmil
Solution structure of the FCS zinc finger domain of human LMBL2
Descriptor: LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE 2 PROTEIN, ZINC ION
Authors:Lechtenberg, B.C, Allen, M.D, Bycroft, M.
Deposit date:2008-10-10
Release date:2009-01-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution Structure of the Fcs Zinc Finger Domain of the Human Polycomb Group Protein L(3)Mbt-Like 2.
Protein Sci., 18, 2009
2RJC
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BU of 2rjc by Molmil
Crystal structure of L3MBTL1 protein in complex with MES
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Lethal(3)malignant brain tumor-like protein, SULFATE ION
Authors:Allali-Hassani, A, Liu, Y, Herzanych, N, Ouyang, H, Mackenzie, F, Crombet, L, Loppnau, P, Kozieradzki, I, Vedadi, M, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J.R, Structural Genomics Consortium (SGC)
Deposit date:2007-10-14
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
2RJE
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BU of 2rje by Molmil
Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), orthorhombic form II
Descriptor: CHLORIDE ION, Histone H4, Lethal(3)malignant brain tumor-like protein
Authors:Allali-Hassani, A, Liu, Y, Herzanych, N, Ouyang, H, Mackenzie, F, Crombet, L, Loppnau, P, Kozieradzki, I, Vedadi, M, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J.R, Structural Genomics Consortium (SGC)
Deposit date:2007-10-14
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
2RJF
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BU of 2rjf by Molmil
Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 12-30), orthorhombic form I
Descriptor: Histone H4, Lethal(3)malignant brain tumor-like protein
Authors:Allali-Hassani, A, Liu, Y, Herzanych, N, Ouyang, H, Mackenzie, F, Crombet, L, Loppnau, P, Kozieradzki, I, Vedadi, M, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J.R, Structural Genomics Consortium (SGC)
Deposit date:2007-10-14
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
2RJD
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BU of 2rjd by Molmil
Crystal structure of L3MBTL1 protein
Descriptor: Lethal(3)malignant brain tumor-like protein
Authors:Allali-Hassani, A, Liu, Y, Herzanych, N, Ouyang, H, Mackenzie, F, Crombet, L, Loppnau, P, Kozieradzki, I, Vedadi, M, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J.R, Structural Genomics Consortium (SGC)
Deposit date:2007-10-14
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
2PQW
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BU of 2pqw by Molmil
Crystal structure of L3MBTL1 in complex with H4K20Me2 (residues 17-25), trigonal form
Descriptor: ACETATE ION, Histone H4, Lethal(3)malignant brain tumor-like protein
Authors:Allali-Hassani, A, Liu, Y, Herzanych, N, Ouyang, H, Mackenzie, F, Crombet, L, Loppnau, P, Kozieradzki, I, Vedadi, M, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J.R, Structural Genomics Consortium (SGC)
Deposit date:2007-05-02
Release date:2007-07-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:L3MBTL1 recognition of mono- and dimethylated histones.
Nat.Struct.Mol.Biol., 14, 2007
4XVX
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BU of 4xvx by Molmil
Crystal structure of an acyl-ACP dehydrogenase
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Acyl-[acyl-carrier-protein] dehydrogenase MbtN, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ...
Authors:Chai, A, Johnston, J.M, Bunker, R.D, Lott, J.S, Baker, E.N, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-28
Release date:2015-02-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket.
Acta Crystallogr.,Sect.D, 71, 2015
8QN5
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BU of 8qn5 by Molmil
M. tuberculosis salicylate synthase MbtI in complex with methyl-AMT (new crystal form)
Descriptor: 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, AMMONIUM ION, CITRATE ANION, ...
Authors:Mori, M, Villa, S, Meneghetti, M, Bellinzoni, M.
Deposit date:2023-09-25
Release date:2023-11-15
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.544 Å)
Cite:Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery.
Pharmaceuticals, 16, 2023
4L59
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BU of 4l59 by Molmil
Crystal structure of the 3-MBT repeat domain of L3MBTL3 and UNC2533 complex
Descriptor: 4-(pyrrolidin-1-yl)-1-{4-[2-(pyrrolidin-1-yl)ethyl]phenyl}piperidine, Lethal(3)malignant brain tumor-like protein 3, SULFATE ION, ...
Authors:Zhong, N, Dong, A, Ravichandran, M, Camerino, M.A, Dickson, B.M, James, L.I, Baughman, B.M, Norris, J.L, Kireev, D.B, Janzen, W.P, Graslund, S, Frye, S.V, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2013-06-10
Release date:2013-07-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.
Medchemcomm, 4, 2013
4FL6
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BU of 4fl6 by Molmil
Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215
Descriptor: Lethal(3)malignant brain tumor-like protein 3, UNKNOWN ATOM OR ION, [2-(phenylamino)benzene-1,4-diyl]bis{[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone}
Authors:Zhong, N, Tempel, W, Ravichandran, M, Dong, A, Ingerman, L.A, Graslund, S, Frye, S.V, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2012-06-14
Release date:2012-06-27
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
Nat. Chem. Biol., 9, 2013
6NFX
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BU of 6nfx by Molmil
MBTD1 MBT repeats
Descriptor: GLYCEROL, MBT domain-containing protein 1,Enhancer of polycomb homolog 1, SODIUM ION, ...
Authors:Zhang, H, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-12-21
Release date:2019-01-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.
Cell Rep, 30, 2020
3OQ5
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BU of 3oq5 by Molmil
Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1
Descriptor: Cellular tumor antigen p53, Lethal(3)malignant brain tumor-like protein
Authors:Roy, S, West, L.E, Weiner, K.L, Hayashi, R, Shi, X, Appella, E, Gozani, O, Kutateladze, T.
Deposit date:2010-09-02
Release date:2010-09-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5005 Å)
Cite:The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression.
J.Biol.Chem., 285, 2010
8QC4
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BU of 8qc4 by Molmil
M. tuberculosis salicylate synthase MbtI in complex with 5-(3-carboxyphenyl)furan-2-carboxylic acid
Descriptor: 5-(3-carboxyphenyl)furan-2-carboxylic acid, GLYCEROL, SULFATE ION, ...
Authors:Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M.
Deposit date:2023-08-25
Release date:2023-11-15
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.578 Å)
Cite:Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery.
Pharmaceuticals, 16, 2023
3ST6
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BU of 3st6 by Molmil
Structure of a M. tuberculosis Synthase, MbtI, in Complex with an Isochorismate Analogue Inhibitor
Descriptor: 3-[(1-carboxyethenyl)oxy]-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-07-08
Release date:2012-05-30
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
3RV9
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BU of 3rv9 by Molmil
Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Ethyl R-Group
Descriptor: 3-{[(1Z)-1-carboxybut-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
3RV8
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BU of 3rv8 by Molmil
Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group
Descriptor: 3-{[(E)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(Z)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
3RV7
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BU of 3rv7 by Molmil
Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Isopropyl R-Group
Descriptor: 3-{[(1Z)-1-carboxy-3-methylbut-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
3RV6
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BU of 3rv6 by Molmil
Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Phenyl R-Group
Descriptor: 3-{[(E)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(Z)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI, ...
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
2RHU
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BU of 2rhu by Molmil
Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to dimethyl-lysine and in chimera with histone H3.3(28-34)
Descriptor: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein, N-DIMETHYL-LYSINE, ...
Authors:Li, H, Patel, D.J.
Deposit date:2007-10-09
Release date:2007-12-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger.
Mol.Cell, 28, 2007
6ZA4
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BU of 6za4 by Molmil
M. tuberculosis salicylate synthase MbtI in complex with 5-(3-cyanophenyl)furan-2-carboxylate
Descriptor: 5-(3-cyanophenyl)furan-2-carboxylic acid, CHLORIDE ION, Salicylate synthase
Authors:Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M.
Deposit date:2020-06-04
Release date:2020-07-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Shedding X-ray Light on the Role of Magnesium in the Activity ofMycobacterium tuberculosisSalicylate Synthase (MbtI) for Drug Design.
J.Med.Chem., 63, 2020
3VEH
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BU of 3veh by Molmil
Structure of a M. tuberculosis salicylate synthase, MbtI, in complex with an inhibitor methylAMT
Descriptor: 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Bulloch, E.M, Chi, G, Manos-Turvey, A, Johnston, J.M, Baker, E.N, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-01-08
Release date:2012-06-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis.
Biochemistry, 51, 2012
6SAN
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BU of 6san by Molmil
SALSA / DMBT1 / GP340 SRCR domain 8 soaked in calcium and magnesium
Descriptor: CHLORIDE ION, Deleted in malignant brain tumors 1 protein, GLYCEROL, ...
Authors:Reichhardt, M.P, Johnson, S, Loimaranta, V, Lea, S.M.
Deposit date:2019-07-17
Release date:2020-03-18
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold.
Life Sci Alliance, 3, 2020
3UWN
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BU of 3uwn by Molmil
The 3-MBT repeat domain of L3MBTL1 in complex with a methyl-lysine mimic
Descriptor: Lethal(3)malignant brain tumor-like protein 1, UNKNOWN ATOM OR ION, [2-(phenylamino)benzene-1,4-diyl]bis{[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone}
Authors:Zhong, N, Tempel, W, Wernimont, A.K, Graslund, S, Ingerman, L.A, Korboukh, V, Kireev, D.B, Gao, C, Frye, S.V, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2011-12-02
Release date:2012-03-07
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The 3-MBT repeat domain of L3MBTL1 in complex with a methyl-lysine mimic
To be Published
3P8H
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BU of 3p8h by Molmil
Crystal structure of L3MBTL1 (MBT repeat) in complex with a nicotinamide antagonist
Descriptor: 3-bromo-5-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbonyl]pyridine, GLYCEROL, Lethal(3)malignant brain tumor-like protein, ...
Authors:Lam, R, Herold, J.M, Ouyang, H, Tempel, W, Gao, C, Ravichandran, M, Senisterra, G, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Vedadi, M, Kireev, D, Frye, S.V, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2010-10-13
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Small-molecule ligands of methyl-lysine binding proteins.
J.Med.Chem., 54, 2011
2RHI
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BU of 2rhi by Molmil
Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with H1.5K27me2 at 1.66 angstrom
Descriptor: DI(HYDROXYETHYL)ETHER, Histone H1.5, Lethal(3)malignant brain tumor-like protein, ...
Authors:Li, H, Patel, D.J.
Deposit date:2007-10-09
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger.
Mol.Cell, 28, 2007

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